Posttraumatic Stress Disorder (PTSD) and Instigation of Cardiovascular Events: Ischemic Heart Disease (IHD) and Atrial Fibrillation (AF)

Habbal, Ahmad B; White, Chantelle T; Shamim, Humaira; Shouli, Roba Al; Mohammed, Lubna

doi:10.7759/cureus.30583

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…While AF is more common among people with PTSD (e.g. reviewed in [48]), in our study AF did not exhibit a significant genetic correlation with PTSD. This could be because there is truly no genetic overlap between the two, or because the genome-wide genetic correlation was not able to capture the presence of localized opposing genetic correlations or divergent biological pathways between AF and PTSD.…”

Section: Causal Associations Between Ptsd and Cvdcontrasting

confidence: 75%

A genetic exploration of the relationship between Posttraumatic Stress Disorder and cardiovascular diseases

Lukas,

Veeneman,

Smit

et al. 2024

Preprint

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Background and Aims Experiencing a traumatic event may lead to Posttraumatic Stress Disorder (PTSD), including symptoms such as flashbacks and hyperarousal. Individuals suffering from PTSD are at increased risk of cardiovascu- lar disease (CVD), but it is unclear why. This study assesses shared genetic liability and potential causal pathways between PTSD and CVD. Methods We leveraged summary-level data of genome-wide association studies (PTSD: N= 1,222,882; atrial fibril- lation (AF): N=482,409; coronary artery disease (CAD): N=1,165,690; hypertension: N=458,554; heart failure (HF): N=977,323). First, we estimated genetic correlations and utilized genomic structural equation modeling to identify a common genetic factor for PTSD and CVD. Next, we assessed biological, behavioural, and psychosocial factors as potential mediators. Finally, we employed multivariable Mendelian randomiza- tion to examine causal pathways between PTSD and CVD, incorporating the same potential mediators. Results Significant genetic correlations were found between PTSD and CAD, HT, and HF (rg =0.21-0.32, p < 3.08 x 10−16), but not between PTSD and AF. Insomnia, smoking, alcohol dependence, waist-to-hip ratio, and inflammation (IL6, C-reactive protein) partly mediated these associations. Mendelian randomization indicated that PTSD causally increases CAD (IVW OR=1.53, 95% CIs=1.19-1.96, p=0.001), HF (OR=1.44, CIs=1.08-1.92, p=0.012), and to a lesser degree hypertension (OR=1.25, CIs=1.05-1.49, p=0.012). While insomnia, smoking, alcohol, and inflammation were important mediators, independent causal effects also remained. Conclusions In addition to shared genetic liability between PTSD and CVD, we present strong evidence for causal effects of PTSD on CVD. Crucially, we implicate specific lifestyle and biological mediators (insomnia, substance use, inflammation) which has important implications for interventions to prevent CVD in PTSD patients.

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Section: Causal Associations Between Ptsd and Cvdcontrasting

confidence: 75%

A genetic exploration of the relationship between Posttraumatic Stress Disorder and cardiovascular diseases

Lukas,

Veeneman,

Smit

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Багато досліджень виявили зв'язок між ПТСР з ішемічною хворобою серця (ІХС) та з фібриляцією передсердь (ФП). Можливі механізми цього зв'язку пов'язані з порушенням осі гіпоталамус-гіпофіз-надниркові залози та симпатичної нервової системи, що може сприяти гіперкоагуляції, підвищенню частоти серцевих скорочень, гіпертензії, дисліпідемії та хронічному запаленню, які, в свою чергу, причетні до ризику розвитку ІХС та ФП [17]. Згідно науковими джерелами ветерани з посттравматичним стресовим розладом у пізньому віці мають на 26% підвищений ризик виникнення серцево-судинної недостатності, на 49% підвищений ризик виникнення інфаркту міокарда та на 35% підвищеного ризику розвитку серцево-судинних розладів у порівнянні з ветеранами без посттравматичного стресового розладу в пізньому віці [5].…”

Section: вплив птср на соматичне здоров'я 1 серцево-судинні захворюванняunclassified

Medico-Biological and Socio-Economic Impact of Post-Traumatic Stress Disorder on the Population in the Conditions of Hostilities

Vasylevskyi,

Glagovych,

Liutianska

et al. 2023

Med. Sci. of Ukr.

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Background. Investigating the medical-biological and socio-economic impacts of PTSD on a country's population is essential, as PTSD can cause serious mental and somatic health issues, affect work capacity and overall quality of life, and have long-term consequences for veterans and survivors. Understanding and studying the causes and consequences of PTSD is crucial for developing effective prevention and treatment strategies and ensuring national security and sustainable development of the country. Aim: To analyze the medical-biological and socio-economic consequences of PTSD on veterans and the population as a whole. Materials and methods. A data analysis was conducted using information obtained from online database searches in "PubMed," "National Institute on Alcohol Abuse and Alcoholism," "ScienceDirect," and "Psychiatrist.com," with keywords such as "post-traumatic stress disorder," "civilian population," "military," "veterans," "comorbid conditions," "alcoholism," "drug addiction," "economic burden," "disability," "costs," "socio-economic status," "combat operations," and "support for survivors." Results. PTSD is a significant societal and economic challenge. Negative trends of these consequences are most acutely manifested in countries experiencing recent or ongoing military conflicts, where the dynamics of PTSD are increasing. Timely diagnosis and active public education are extremely important for preventing the development of chronic conditions and avoiding limitations on the functioning of survivors. Real-world practice demonstrates that support for individuals with PTSD often includes not only professional medical therapy but also assistance in employment, housing, and social adaptation. Conclusion. PTSD is a serious problem for veterans and civilian populations, requiring attention and support from the government and society. Further research and the development of effective treatment and support methods for people suffering from PTSD are needed to improve their quality of life and promote social integration.

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Sex differences in Black Veterans with PTSD: women versus men have higher sympathetic activity, inflammation, and blunted cardiovagal baroreflex sensitivity

Fonkoue,

Tahsin,

Jones

et al. 2023

Clin Auton Res

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Posttraumatic Stress Disorder (PTSD) and Instigation of Cardiovascular Events: Ischemic Heart Disease (IHD) and Atrial Fibrillation (AF)

Cited by 4 publications

References 24 publications

A genetic exploration of the relationship between Posttraumatic Stress Disorder and cardiovascular diseases

A genetic exploration of the relationship between Posttraumatic Stress Disorder and cardiovascular diseases

Medico-Biological and Socio-Economic Impact of Post-Traumatic Stress Disorder on the Population in the Conditions of Hostilities

Sex differences in Black Veterans with PTSD: women versus men have higher sympathetic activity, inflammation, and blunted cardiovagal baroreflex sensitivity

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