Posttraumatic Survival of Sensory Neurons during Allotransplantation of Rat Embryonic Tissues into the Nerve

Масгутов, Р. Ф.; Masgutova, Galina; Raginov, I. S.; Malomuzh, A. I.; Nigmetzyanova, M. V.; Chelyshev, Yu. A.

doi:10.1007/s10517-009-0540-0

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Evaluation Of the Degree Of Nerve Regeneration After Treatme1

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2015

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“…Of note, the neuroprotective effect is associated with conduits primed with stem cells pre-differentiated towards a Schwann cell phenotype [ 70 ]. There is evidence to suggest that embryonic neural tissue allografted into the injured site supports the survival of sensory neurons [ 98 ].…”

Section: Evaluation Of the Degree Of Nerve Regeneration After Treatmementioning

confidence: 99%

Injured Nerve Regeneration using Cell-Based Therapies: Current Challenges

2015

Acta Naturae

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This paper reviews the recent research progress in the past several years on promoting peripheral nerve recovery using stem and progenitory cells. The emphasis is placed on studies aimed at assessing various stem cells capable of expressing neurotrophic and growth factors and surviving after implantation in the nerve or a conduit. Approaches to improving nerve conduit design are summarized. The contribution of stem cells to axonal regeneration and neural repair is discussed. The side effects associated with cell-based treatment are highlighted. From the studies reviewed, it is concluded that the fate of transplanted stem cells needs further elucidation in a microenvironment-dependent manner.

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Section: Evaluation Of the Degree Of Nerve Regeneration After Treatmementioning

confidence: 99%

Injured Nerve Regeneration using Cell-Based Therapies: Current Challenges

2015

Acta Naturae

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show abstract

Posttraumatic Survival of Sensory Neurons during Allotransplantation of Rat Embryonic Tissues into the Nerve

Abstract: Allotransplantation of the liver, hindlimb, and bone marrow tissues from 14-day-old embryos into the sciatic nerve had a modulatory effect on survival of various populations of axotomized neurons in L5 spinal ganglion in an adult rat.

Cited by 1 publication

References 6 publications

Injured Nerve Regeneration using Cell-Based Therapies: Current Challenges

Injured Nerve Regeneration using Cell-Based Therapies: Current Challenges

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