Postural Control While Walking Interferes With Spatial Learning in Older Adults Navigating in a Real Environment

Agathos, Catherine; Ramanoël, Stephen; Bécu, Marcia; Bernardin, Delphine; Habas, Christophe; Arleo, Angelo

doi:10.3389/fnagi.2020.588653

Cited by 5 publications

(1 citation statement)

References 112 publications

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“… 16 In Streetlab, we identified novel indicators of postural control interfering with spatial learning and navigation capabilities in the elderly, and we tested the hypothesis that navigation difficulties in elderly people are associated with deficits in processing and encoding spatial cues. 17 , 18 We also evaluated the age-related differences in functional and structural connectivity of spatial navigation. 19 , 20 Here, we shall report elements of our experience in the field of IRDs.…”

Section: Overviewmentioning

confidence: 99%

Assessing Photoreceptor Status in Retinal Dystrophies: From High-Resolution Imaging to Functional Vision

Sahel

Grieve

Pagot

et al. 2021

American Journal of Ophthalmology

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To describe the value of integrating phenotype/genotype data, disease staging, and evaluation of functional vision in patient-centered management of retinal dystrophies. • METHODS: (1) Cross-sectional structure-function and retrospective longitudinal studies to assess the correlations between standard fundus autofluorescence (FAF), optical coherence tomography, visual acuity (VA), and perimetry (visual field [VF]) examinations to evaluate photoreceptor functional loss in a cohort of patients with rod-cone dystrophy (RCD); (2) flood-illumination adaptive optics (FIAO) imaging focusing on photoreceptor misalignment and orientation of outer segments; and (3) evaluation of the impact of visual impairment in daily life activities, based on functional (visual and mobility) vision assessment in a naturalistic environment in visually impaired subjects with RCD and subjects treated with Luxturna R for RPE65 -related Leber congenital amaurosis before and after therapy. • RESULTS: The results of the cross-sectional transversal study showed that (1) VA and macular sensitivity were weakly correlated with the structural variables; and (2) functional impairment (VF) was correlated with reduction of anatomical markers of photoreceptor structure and increased width of autofluorescent ring. The dimensions of the ring of increased FAF evolved faster. Other criteria that differed among groups were the lengths of the ellipsoid zone, the external limiting membrane, and

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