Postural Instability in Children with ADHD Is Improved by Methylphenidate

Bucci, Maria Pia; Stordeur, Coline; Acquaviva, Éric; Peyre, Hugo; Delorme, Richard

doi:10.3389/fnins.2016.00163

Cited by 21 publications

(15 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Attention deficit hyperactivity disorder (ADHD) is associated with poor gross and fine motor control tasks (Piek et al, 1999;Wang et al, 2011;Papadopoulos et al, 2014). Several studies also reported postural instability in ADHD children compared to TD children (Zang et al, 2002;Wang et al, 2003;Buderath et al, 2009;Bucci et al, 2014Bucci et al, , 2016. Interestingly, a study by Hove et al (2015) reported for the first time a positive correlation between postural sway and cerebellar gray matter volume in adults with ADHD, providing additional support for cerebellar involvement in ADHD.…”

Section: Introductionmentioning

confidence: 99%

Discriminant validity of spatial and temporal postural index in children with neurodevelopmental disorders

Bucci

Goulème

Stordeur³

et al. 2017

Intl J of Devlp Neuroscience

Self Cite

View full text Add to dashboard Cite

Autism, learning disabilities and attention deficit/hyperactive disorder are often comorbid disorders. In order to try and find some markers that might be transnosographic, we hypothesized that abnormal postural sway profiles may discriminate children with neurodevelopmental disorders (NDDs) from typically developing children. The aim of our study was thus to compare spatial and temporal measures of the Center of Pressure in three distinct groups of children with NDDs (high functioning autism spectrum disorders, learning disabilities (dyslexia) and attention deficit/hyperactive disorders) and in typically developing children. Postural performances were thus evaluated in 92 children (23 per group, sex-, age- and IQ-matched groups) by using the Multitest Equilibre platform (Framiral). Two viewing conditions (eyes open and eyes closed) were tested on a stable and unstable platform. Results reported similar poor postural instability for the three groups of children with NDDs with respect to the typically developing children, and this was observed for both spatial as well as temporal analysis of displacement of the center of pressure. Such postural instability observed in children with NDDs could be due to impairment in using sensorial inputs to eliminate body sway, probably due to poor cerebellar integration.

show abstract

Section: Introductionmentioning

confidence: 99%

Discriminant validity of spatial and temporal postural index in children with neurodevelopmental disorders

Bucci

Goulème

Stordeur³

et al. 2017

Intl J of Devlp Neuroscience

Self Cite

View full text Add to dashboard Cite

show abstract

“…In yet another study designed based on this finding, treadmill exercises were shown to contribute to the improvement of ADHD symptoms by reducing Purkinje cell loss and astrocytic activation in spontaneous hyperactive rats [10]. A study by Bucci et al, the MPH treatment was shown to improve the decreased postural instability, which was increased as a clear sign of cerebellar dysfunction in children with ADHD compared with controls [33]. However, it is not yet clear when and how cerebellar damage is initiated, what triggers the damage, and which pathophysiological processes are involved in ADHD.…”

Section: Discussionmentioning

confidence: 96%

“…Strong evidences from neuroimaging studies are the reduction in cerebellar volume, especially a reduction in the posterior lobe including lobes 8 and 9 [31], the evidence of correlation with reduction in the posterior lobe volume in ADHD clinical features, and the association of ADHD symptomatology with cerebellar vermis [8,30,31]. The significant improvement was observed in the cerebellar volume in the ADHD cases treated with methylphenidate (MPH) compared to those not treated with MPH and the significant improvement was observed in postural control in ADHD cases with MPH treatment implicate the cerebellum and cerebellocortical pathways in ADHD etiology [32,33]. In a study evaluating the role of atypical fronto-cerebellar circuit in the etiopathogenesis of ADHD, an increased neuronal activation was detected in the posterior cerebellar lobe [11].…”

Section: Discussionmentioning

confidence: 99%

Attention deficit hyperactivity disorder and anti-Purkinje autoantibodies: no link?

Çetin

Cetin

Işık

et al. 2018

Psychiatry and Clinical Psychopharmacology

View full text Add to dashboard Cite

OBJECTIVES: Attention Deficit Hyperactivity Disorder (ADHD) is a neurobehavioral disorder that begins in early childhood, and many factors play role in its etiology. Many studies have been conducted to identify the causes of ADHD, but the exact factors are still unknown. Although cerebellar dysfunction in the etiology of ADHD was shown in different studies, the possible causes of dysfunction and the role of neuroinflammation among these causes has not been clarified yet. Anti-Yo is an antibody against the antigens in the cytoplasm of purkinje cells and indicates cerebellar degeneration, and Anti-Hu and Anti-Ri are antibodies against cellular nuclear antigens of purkinje cells. This study aimed to evaluate the role of neuroinflammation that is a potential cause of cerebellar dysfunction, which is thought to be an important factor in the development of ADHD. METHODS: This is a cross-sectional and descriptive study that aimed to evaluate the potential association between ADHD and cerebellar neuroinflammation by comparing the serum antipurkinje cell antibody measurements between case and control groups. The cases were recruited at the Gazi University Child Psychiatry Department, and laboratory analyses were performed at the Ankara Numune Research and Training Hospital Medical Microbiology Department. Sixty children and adolescents with ADHD, and 60 healthy controls were planned to be included in the study. Cases that admitted with ADHD symptoms were given Conners teacher forms according to routine procedure; then the cases with scores over the cutoff of Conners teacher form were evaluated clinically for a diagnosis of ADHD, and after clinical evaluations they were asked to participate the study if they met the eligibility criteria. If they accept to participate the study, informed consents were given to cases and parents, and meanwhile, Turkish version of Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version (K-SADS-PL) was also applied to cases. A 5ml serum was spared from the blood samples that obtained for routine test during diagnosis. Control group was planned to be formed from the blood samples of 60 healthy children that admitted to child psychiatry clinic for counselling. At the time of analyses, diluted according to the directions of manufacturers, incubated with fluorescent staining including antibodies (Anti-Hu, Anti-Yo, and Anti-Ri), and evaluated under immunofluorescent microscope by three specialists. RESULTS: Sixty healthy volunteers and 60 cases with ADHD were included in the study. Some of the samples were excluded from the study due to the damage to laboratory tubes during transport. Assessments were conducted with 52 ADHD and 52 healthy control samples. The male/female ratio was 41/11(78.8%/21.2%) in the patient group and 35/17 (67.3%/32.7%) in the control group (p = 0.185). Average age was 9.81 ± 2.41 in the patient group and 9.46 ± 2.14 in the control group (p = 0.442). No positive results were obtained for anti-Purkinje antibody in ADHD or contro...

show abstract

“…Postural control test. The Multitest Equilibre system (www.framiral.fr) was used to evaluate postural stability 29,30 . The displacement of the Center of Pressure (CoP) was sampled at 40 Hz and digitized with 16-bit precision.…”

Section: Methodsmentioning

confidence: 99%

Short rehabilitation training program may improve postural control in children with autism spectrum disorders: preliminary evidences

Caldani

Atzori

Peyre

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

Autism Spectrum Disorders subjects (ASD) is characterized by postural control deficits. This study aimed to explore the effect of a short postural rehabilitation training program on postural capabilities in children with ASD. Two groups (G1 and G2) of twenty children with ASD of IQ-, sex-and age-matched (mean age 11.7 ± 2.4 years) were included in this study. Posture was recorded by using the Balance Quest from Framiral on unstable platform in three different viewing conditions. The rehabilitation program consisted in two distinct postural control training exercises. Postural recordings were performed twice at T1 and T2 for both groups of children. Between T1 and T2 a 6-minute postural training was performed by the G1 group only, while the G2 group had a 6-minute of rest. Children were allocated randomly to the G1 or G2 groups. At T1, postural instability was similar for both groups of ASD children (G1 and G2) desp+\ite viewing conditions. At T2, we observed an improvement of postural control related to a mixed effect of training rehabilitation but also of test-retest. Knowing the potential of new rehabilitation strategies, the impact of postural control deficit in ASD children needs to be reconsidered. Well design case-control studies are requested to ensure scientific validity of postural rehabilitation training program. Autism Spectrum Disorders (ASD) are neurodevelopmental disorders characterized by social communication and social interaction deficits, associated with the presence of restricted, repetitive and stereotyped behaviors 1. Sensorimotor deficits as well as fine and gross motor skill impairment are consistently reported in children with ASD and correlated with the severity of social communication impairment 2,3. Sensory abnormalities are frequently the earliest identifiable clinical features of developmental trajectory impairments 4,5. Similarly to social communication deficit, motor impairments may represent core features of autism when considering a broader spectrum of symptom 6. Several groups measured postural sway in children with ASD and showed that affected children were significantly more unstable than children with neurotypical development 7,8. A larger surface area of the center of pressure (COP) was observed in children with ASD with respect to control participants 9-13 , associated with an increased COP velocity 10,11,14. Postural instability in children with ASD was also more significant when somatosensory inputs were affected, such as standing on an unstable platform with foams under the feet or when wearing a vibrating apparatus on the neck 7,13,15-18. All of these studies reported a significantly larger body sway displacement and/or faster sway velocity in subjects with ASD compared to peers with typical neurodevelopment. It was most likely due to a reduced

show abstract

Postural Instability in Children with ADHD Is Improved by Methylphenidate

Cited by 21 publications

References 41 publications

Discriminant validity of spatial and temporal postural index in children with neurodevelopmental disorders

Discriminant validity of spatial and temporal postural index in children with neurodevelopmental disorders

Attention deficit hyperactivity disorder and anti-Purkinje autoantibodies: no link?

Short rehabilitation training program may improve postural control in children with autism spectrum disorders: preliminary evidences

Contact Info

Product

Resources

About