Postural myoclonus associated with long-term administration of neuroleptics in schizophrenic patients

Fukuzako, Hiroshi; Tominaga, Hidefumi; Izumi, Kanji; Koja, Takeshi; Nomoto, Masahiro; Hokazono, Yoshiro; Kamei, Kaeko; Fujii, Hideo; Fukuda, Takeo; Matsumoto, Keīichi

doi:10.1016/0006-3223(90)90048-7

Cited by 22 publications

(12 citation statements)

References 15 publications

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“…Classic antipsychotics, including haloperidol, have been reported to cause multifocal myoclonus of both arms, sensitive to posture [25, 85]; of limbs and of the face [16]; and of the trunk and limbs [93]. Atypical antipsychotics, including quetiapine and olanzapine, can cause both multifocal [33, 72] and generalized [29, 73, 92] myoclonus.…”

Section: Resultsmentioning

confidence: 99%

The clinical heterogeneity of drug-induced myoclonus: an illustrated review

2016

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A wide variety of drugs can cause myoclonus. To illustrate this, we first discuss two personally observed cases, one presenting with generalized, but facial-predominant, myoclonus that was induced by amantadine; and the other presenting with propriospinal myoclonus triggered by an antibiotic. We then review the literature on drugs that may cause myoclonus, extracting the corresponding clinical phenotype and suggested underlying pathophysiology. The most frequently reported classes of drugs causing myoclonus include opiates, antidepressants, antipsychotics, and antibiotics. The distribution of myoclonus ranges from focal to generalized, even amongst patients using the same drug, which suggests various neuro-anatomical generators. Possible underlying pathophysiological alterations involve serotonin, dopamine, GABA, and glutamate-related processes at various levels of the neuraxis. The high number of cases of drug-induced myoclonus, together with their reported heterogeneous clinical characteristics, underscores the importance of considering drugs as a possible cause of myoclonus, regardless of its clinical characteristics.Electronic supplementary materialThe online version of this article (doi:10.1007/s00415-016-8357-z) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

The clinical heterogeneity of drug-induced myoclonus: an illustrated review

2016

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“…Case 2 had a long history of exposure to antipsychotic agents, which may have rendered him parkinsonian. Tardive movement disorders induced by these agents include tardive myoclonus 14, 15. Tardive myoclonus is usually seen in the upper limbs and during sustained postures.…”

Section: Discussionmentioning

confidence: 99%

Speech‐activated myoclonus: An uncommon form of action myoclonus

et al. 2005

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We describe an unusual form of facial myoclonus activated by speech in 3 patients with different underlying neurological diseases and present the electrophysiological investigations and results of structural and functional imaging. In 1 of 2 patients in whom jerk-locked electroencephalogram (EEG) back-averaging was done, a cortical potential clearly preceded the facial jerks. In the second patient, a cortical potential preceding the jerk was not certain. In the third patient, the resting EEG contained outbursts of symmetric, slower frequencies of indeterminate significance. An epileptiform disorder was suspected in this patient.

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“…Above the upper limit, on the other hand, either a lack of further therapeutic effect or tolerability problems arise. 7,8 Because of the paucity of specific studies on LAIs, their therapeutic reference range is settled identical to that of oral formulations. 7 A recent review performed by Schoretsanitis and colleagues 9 aims at providing a practical framework for the successful integration of TDM in LAI formulations.…”

Section: Switch To 3-month Long-acting Injectable Paliperidone May De...mentioning

confidence: 99%

“…Various disorders can cause myoclonus, including neurodegenerative and systemic metabolic disorders as well as central nervous system infections. In addition, myoclonus has been reported as a adverse effect of certain medications, notably dopamine-blocking agents such as antipsychotic drugs and metoclopramide, in patients who have been taking them for a relatively long period 5–7 . Postural myoclonus has been found to be associated with the long-term administration of neuroleptics in patients with schizophrenia 7 .…”

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Tardive Myoclonus Responsive to Clozapine Misdiagnosed as Restless Leg Syndrome

Selçuk

2021

J Clin Psychopharmacol

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14. fda.gov. FDA consumer update: grapefruit juice and some drugs don't mix. Available at: https://www.fda. gov/files/about%20fda/published/ Grapefruit-Juice-and-Some-Drugs-Don% 27t-Mix-%28PDF%29.pdf. Accessed January 11, 2021. 15. Murphy MM, Barraj LM, Rampersaud GC. Consumption of grapefruit is associated with higher nutrient intakes and diet quality among adults, and more favorable anthropometrics in

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Postural myoclonus associated with long-term administration of neuroleptics in schizophrenic patients

Cited by 22 publications

References 15 publications

The clinical heterogeneity of drug-induced myoclonus: an illustrated review

The clinical heterogeneity of drug-induced myoclonus: an illustrated review

Speech‐activated myoclonus: An uncommon form of action myoclonus

Tardive Myoclonus Responsive to Clozapine Misdiagnosed as Restless Leg Syndrome

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