Postural orthostatic tachycardia syndrome associated with multiple sclerosis

Adamec, Ivan; Lovrić, Mila; Žaper, Dinka; Barušić, Anabella Karla; Bach, Ivo; Junaković, Anamari; Mišmaš, Antonija; Habek, Mario

doi:10.1016/j.autneu.2012.11.009

Cited by 22 publications

(12 citation statements)

References 17 publications

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“…Clinical evidence that POTS may have an autoimmune etiology has been mounting whereas POTS and other autonomic disorders have been observed in patients with multiple sclerosis, myasthenia gravis, Sjo¨gren's syndrome, SLE, RA and APS. [16][17][18][19] POTS can commonly occur after a viral illness 1 or after vaccination, 20 providing further evidence that an autoimmune and/or immunemediated process may underlie the etiology of POTS. However, the prevalence of autonomic disorders in patients with autoimmune conditions or the prevalence of autoimmune disorders in patients with POTS patients has not been determined.…”

Section: Resultsmentioning

confidence: 98%

Autoimmune markers and autoimmune disorders in patients with postural tachycardia syndrome (POTS)

Blitshteyn

2015

Lupus

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Section: Resultsmentioning

confidence: 98%

Autoimmune markers and autoimmune disorders in patients with postural tachycardia syndrome (POTS)

Blitshteyn

2015

Lupus

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“…POTS has been reported occurring in MS patients and their connection is explained by the presence of demyelinating brainstem and hemispheric lesions that disrupt the physiological heart rate variability modulation [90,94,95]. Almost half of POTS patients complain of fatigue and its appearance in MS patients aggravates the common symptom of fatigue that MS patient experience very often [96].…”

Section: Autonomic Nervous System Abnormalities Associated With Brainmentioning

confidence: 95%

Evaluation of brainstem involvement in multiple sclerosis

Habek¹

2013

Expert Review of Neurotherapeutics

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Evidence suggests that brainstem involvement in multiple sclerosis (MS) is one of the major predictive factors for future disability. Recent work demonstrates that brainstem pathology is more frequent than can be depicted either clinically or with the use of MRI. Evoked potentials have been shown to reliably predict disability in MS patients. This review will consider the main clinical and neuroradiological aspects together with the role of different neurophysiological tests, as ancillary tools to conventional studies, in evaluation of brainstem pathology in MS patients. Specifically, the role of vestibular evoked myogenic potentials, trigeminal somatosensory evoked potentials, autonomic nervous system testing and sleep testing in MS, as correlates of brainstem damage, will be explored.

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“…Visceral symptoms are perhaps the most evident in clinical practice with reports documenting bladder, bowel or sexual dysfunction in 50-75% (Betts et al, 1993(Betts et al, , 1994Fowler and Henry, 1996;Hinds et al, 1990). Cardiovascular manifestations such as syncope, orthostatic dizziness and excessive postural tachycardia, the latter of which has been documented at rates of up to 63% (Adamec et al, 2012(Adamec et al, , 2013Flachenecker et al, 1999;Kanjwal et al, 2010;Sterman et al, 1985), have also been reported, although the pathophysiological relationship of these disorders to MS is not clearly established. Other symptoms, such as changes in autonomically-mediated pupillary, secretomotor, thermoregulatory and sweat function are less commonly appreciated (McDougall andMcLeod, 2003, Spies, 2008).…”

Section: Introductionmentioning

confidence: 93%