Postvaccination SARS‐CoV‐2 infection among healthcare workers: A systematic review and meta‐analysis

Chandan, Saurabh; Khan, Shahab R.; Deliwala, Smit; Mohan, Babu P.; Ramai, Daryl; Chandan, Ojasvini Choudhry; Facciorusso, Antonio

doi:10.1002/jmv.27457

Cited by 23 publications

(26 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Published systematic reviews and meta-analyses show a significant effect of vaccination against SARS-CoV-2 on the significant prevention of symptomatic and asymptomatic COVID-19 among HCWs [ 24 , 25 , 26 , 27 ]. A meta-analysis by Chandan et al points to a reduced incidence of COVID-19 infection and reduced hospitalizations and deaths among vaccinated healthcare professionals.…”

Section: Discussionmentioning

confidence: 99%

“…The collected literature data differed in terms of, i.a., the type of vaccine used, the number of HCWs, or the ethnic origin of the respondents. Additionally, most of the studies found were retrospective in nature, which could have contributed to misselection [ 25 ]. Another published meta-analysis showed that COVID-19 vaccines are effective after just one dose.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Early and Longitudinal Humoral Response to the SARS-CoV-2 mRNA BNT162b2 Vaccine in Healthcare Workers: Significance of BMI, Adipose Tissue and Muscle Mass on Long-Lasting Post-Vaccinal Immunity

Golec

Fronczek

Zembala-John

et al. 2022

Viruses

View full text Add to dashboard Cite

Background: This study aimed to investigate the early and longitudinal humoral response in Healthcare Workers (HCWs) after two doses of the BNT162b2 vaccine and to assess the association between metabolic and anthropometric parameters and the humoral response after vaccination. Methods: The study included 243 fully vaccinated HCWs: 25.50% previously infected with SARS-CoV-2 (with prior history of COVID-19—PH) and 74.40%—uninfected, seronegative before the first vaccination (with no prior history of COVID-19—NPH). IgG antibodies were measured, and sera were collected: prior to the vaccination, 21 days after the first dose, and 14 days and 8 months after the second dose. Results: 21 days after the first dose, 90.95% of individuals were seropositive; 14 days after the second dose, persistent immunity was observed in 99.18% HCWs, 8 months after complete vaccination—in 61.73%. Statistical analysis revealed that HCWs with PH had a greater chance of maintaining a humoral response beyond eight months after vaccination. Increased muscle mass, decreased fat mass, and younger age may positively affect long-term immunity. Smokers have a reduced chance of developing immunity compared to non-smokers. Conclusions: Fully vaccinated HCWs with PH are more likely to be seropositive than fully inoculated volunteers with NPH.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Early and Longitudinal Humoral Response to the SARS-CoV-2 mRNA BNT162b2 Vaccine in Healthcare Workers: Significance of BMI, Adipose Tissue and Muscle Mass on Long-Lasting Post-Vaccinal Immunity

Golec

Fronczek

Zembala-John

et al. 2022

Viruses

View full text Add to dashboard Cite

show abstract

“…Health care workers are still on the front line of the battle against COVID-19 and, therefore, constituted one of the groups at the highest risk of infection during this raging pandemic ( 15 ). Vaccination has been proven to be the key for the reduction of the risk of COVID-19 infection in HCWs ( 16 ), but different studies have observed a drop in antibody levels over time ( 17 , 18 ), which could have clinical consequences. Therefore, several authors have called for action to develop effective therapies and preventive measures to reduce infection and flatten the COVID-19 curve, and, in this context, probiotics could have a role ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effect of Loigolactobacillus coryniformis K8 CECT 5711 consumption in health care workers exposed to COVID-19

et al. 2022

View full text Add to dashboard Cite

Following the spread of the SARS-CoV-2 coronavirus, an unprecedented burden has been placed on health care systems, with health care workers (HCWs) being most at risk of COVID-19 infection. The effect of the probiotic Loigolactobacillus coryniformis K8 CECT 5711 on frontline HCWs exposed to the virus was studied in a randomized, double-blind, placebo controlled trial. Parameters related to the incidence and severity of COVID-19 as well as the immune response and the side effects of the COVID-19 vaccine were evaluated. For 2 months, a group of 250 front-line HCWs over the age of 20 was randomly allocated to receive either L. coryniformis K8 or a placebo daily. SARS-CoV-2 infection incidence was verified via PCR or antigen test. In those volunteers who were vaccinated during the intervention, serum levels of specific IgG were analyzed at the end of the study. The incidence of COVID-19 infection was very low [IR (SD) = 0.016 (0.011)], and no significant difference was found between the groups [IRR (95% CI): 1.008 (0.140–7.268), p = 0.994]. For immune response analysis, the total sample was divided according to the days between the first dose and the antibody analysis (cutoff points were set at ≤ 56, 57–80 and ≥ 81 days). The specific IgG level decreased over time (p > 0.001). However, in the subgroup of subjects for whom more than 81 days had passed since they received the first dose, the specific IgG levels were significantly higher in the those that took the L. coryniformis K8 [7.12 (0.21)] than in the control group [6.48 (0.19)] (P = 0.040). Interestingly, the subjects who started probiotic consumption before the first dose reported significantly fewer side effects (of any kind) at the 1st dose of the vaccine (OR: 0.524, p = 0.043), specifically less arm pain (OR: 0.467, p = 0.017). In conclusion, the administration of L. coryniformis K8 CECT 5711 to HCWs helps to extend the immune protection generated by the COVID-19 vaccine over time.

show abstract

“…A previous study 10 that found a prevalence of COVID‐19 of 2.3% among partially vaccinated and 10.1% among unvaccinated was used to calculate the sample size. Thus, considering an alpha error of 5% and a study power of 80%, it would be necessary to include at least 146 patients in each group.…”

Section: Methodsmentioning

confidence: 99%

“…Among vaccinated patients, the risk of hospitalization, mechanical ventilation, or death for COVID‐19 was significantly decreased. 8 , 9 Data on COVID‐19 among HCW pre‐ and postvaccination are limited, 10 , 11 , 12 and none are available for Brazil, which has one of the highest death tolls worldwide. 13 Therefore, this study aims to evaluate the clinical characteristics and outcomes of HCW with COVID‐19 pre‐ and postvaccination.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and outcomes of healthcare workers with COVID‐19 pre‐ and postvaccination

Filho

Chaves

D'Ávila

et al. 2022

Journal of Medical Virology

View full text Add to dashboard Cite

Vaccines are the most effective strategy to control the spread of coronavirus disease‐2019 (COVID‐19). Data on COVID‐19 among healthcare workers (HCW) pre‐ and postvaccination are limited. This study aims to evaluate the clinical characteristics and outcomes of HCW with COVID‐19 pre‐ and postvaccination. Retrospective cohort study. All HCWs with suspected COVID‐19 were included. Demographic data, occupation, symptoms, work in COVID‐19 area, and vaccination status were collected. There were 22 267 HCW visits for suspected COVID‐19; 7879 (35.4%) tested positive, and 14 388 (64.6%) tested negative. Fever, cough, fatigue, and dyspnea were positive predictors of COVID‐19, and sore throat, headache, coryza, work in a COVID‐19 area, and COVID‐19 vaccination were negative predictors. Of the total number of visits, 41.2% were from vaccinated HCW and 58.8% were from unvaccinated HCW. Among HCWs with COVID‐19, 84 (1.1%) required hospitalization, 11 (0.1%) in an intensive care unit (ICU), with three (0.04%) deaths. Six hospitalizations occurred in vaccinated HCWs, being of short duration, with no need for ICU admission and no deaths. SARS‐CoV‐2 infection prevalence was high among HCW, and vaccinated HCW had fewer hospitalizations, need for ICU, and deaths. Therefore, vaccines may attenuate COVID‐19 severity, and efforts must be concentrated to ensure adequate vaccination for HCW.

show abstract

Postvaccination SARS‐CoV‐2 infection among healthcare workers: A systematic review and meta‐analysis

Cited by 23 publications

References 50 publications

Early and Longitudinal Humoral Response to the SARS-CoV-2 mRNA BNT162b2 Vaccine in Healthcare Workers: Significance of BMI, Adipose Tissue and Muscle Mass on Long-Lasting Post-Vaccinal Immunity

Early and Longitudinal Humoral Response to the SARS-CoV-2 mRNA BNT162b2 Vaccine in Healthcare Workers: Significance of BMI, Adipose Tissue and Muscle Mass on Long-Lasting Post-Vaccinal Immunity

Evaluation of the effect of Loigolactobacillus coryniformis K8 CECT 5711 consumption in health care workers exposed to COVID-19

Clinical characteristics and outcomes of healthcare workers with COVID‐19 pre‐ and postvaccination

Contact Info

Product

Resources

About