Postweaning Enriched Environment Enhances Cognitive Function and Brain-Derived Neurotrophic Factor Signaling in the Hippocampus in Maternally Separated Rats

Cordier, Javier Maximiliano; Aguggia, Julieta Paola; Danelon, Víctor; Mir, Franco Rafael; Rivarola, María Angélica; Mascó, Daniel H.

doi:10.1016/j.neuroscience.2020.09.058

Cited by 23 publications

(16 citation statements)

References 49 publications

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“…It is closely related to learning, memory, emotion, movement, and other functions. Iron deficiency can affect neurometabolism in local brain regions, especially hippocampus (Cordier et al, 2021; Famitafreshi & Karimian, 2020; Kodali, Attaluri, et al, 2021; Kodali, Mishra, et al, 2021; Nelissen et al, 2017). Callahan, Thibert, Wobken, and Georgieff (2013) found that early iron deficiency can change the expression of key genes affecting synaptic plasticity in hippocampus, leading to electrophysiological abnormalities of cells and behavioral abnormalities of animals.…”

Section: Discussionmentioning

confidence: 99%

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Quantitative susceptibility mapping shows lower brain iron content in children with attention‐deficit hyperactivity disorder

Tang

Zhang

Ran

et al. 2022

Human Brain Mapping

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To investigate the feasibility of quantitative susceptibility mapping in children with attention‐deficit hyperactivity disorder (ADHD), 53 children with ADHD aged 5–16 years were prospectively selected as the study group and 49 healthy children matched with age and gender were selected as the control group. All children underwent magnetic resonance imaging conventional sequence, 3D‐T1, and enhanced T2*‐weighted magnetic resonance angiography (ESWAN) sequence scanning. The iron content of brain regions was obtained through software postprocessing, and the iron content of brain regions of children with ADHD and healthy children was compared and analyzed to find out the characteristics of the iron content of brain regions of children with ADHD. The iron content in frontal lobe, globus pallidus, caudate nucleus, substantia nigra, putamen, and hippocampus of children with ADHD was lower than that of healthy children (p < .05). There was no significant difference in the content of iron in the left and right brain regions of children with ADHD (p > .05). The volume of frontal lobe and hippocampus of children with ADHD was lower than that of healthy children (p < .05). Iron content in brain areas such as globus pallidus, caudate nucleus, hippocampus, and putamen could distinguish children with ADHD (Area under curve [AUC] > 0.5, p < .05). Quantitative susceptibility mapping showed decreased iron content in some brain regions of children with ADHD.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Quantitative susceptibility mapping shows lower brain iron content in children with attention‐deficit hyperactivity disorder

Tang

Zhang

Ran

et al. 2022

Human Brain Mapping

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“…These behavioral changes suggest that neonatal pain causes changes in various structures and neurotransmitters involved in spatial short-term and long-term memory only in P45-53 rats. The effect of stress at an early age on memory and the HPA axis, as well as brain structures involved in memory processes in adulthood are well studied ( Krugers and Joëls, 2014 ; Schroeder et al, 2018 ; Bonapersona et al, 2019 ; Cordier et al, 2021 ), but information on the effects of neonatal pain stress on memory and the participation of the HPA axis in this process is very meager. Our work is the first, as far as we know, aimed at studying the effects of early-life inflammatory pain on spatial learning and memory, and the HPA reactivity at different age intervals within the adolescent period.…”

Section: Discussionmentioning

confidence: 99%

“…The longitudinal analysis of outcomes of pain for premature infants in a neonatal clinic found that pain in these infants resulted in impaired cognitive function in the child and adolescent ( Haley et al, 2006 ; Grunau et al, 2009 ; Doesburg et al, 2013 ; Vinall et al, 2014 ; Chau et al, 2017 ). Whereas the long-term influence of non-pain stress (e.g., maternal separation, mother and offspring isolation, early handling or the limited nesting model) on cognitive behavior and memory in animal models is abundant in the literature ( Krugers and Joëls, 2014 ; Schroeder et al, 2018 ; Bonapersona et al, 2019 ; Cordier et al, 2021 ), the long-term consequences of pain stress have been understudied ( Khawla et al, 2017 ), especially considering it prevalence in the clinical setting ( Ranger and Grunau, 2014 ; Mooney-Leber and Brummelte, 2017 ) and the strong connection between neonatal pain and disturbances of central nervous system maturation ( Schwaller and Fitzgerald, 2014 ; Brewer and Baccei, 2020 ; Williams and Lascelles, 2020 ). The neonatal period is a critical period of development due to the rapidly changing neurobiological processes, which result in altered sensitivity to external stimuli and a high level of plasticity of the nervous system ( Lupien et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

The Long-Term Effects of Neonatal Inflammatory Pain on Cognitive Function and Stress Hormones Depend on the Heterogeneity of the Adolescent Period of Development in Male and Female Rats

Butkevich

Mikhailenko

Vershinina

et al. 2021

Front. Behav. Neurosci.

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Exposure to stress at an early age programs the HPA axis which can lead to cognitive deficits in adults. However, it is not known whether these deficits emerge in adulthood or are expressed earlier in life. The aims of the study were to investigate (1) the immediate effects of early injury-induced stress in one-day-old (P1) and repeated stress on at P1 and P2 rat pups on plasma corticosterone levels; and (2) examine the subsequent long-term effects of this early stress on spatial learning and memory, and stress reactivity in early P26-34 and late P45-53 adolescent male and female rats. Intra-plantar injection of formalin induced prolonged and elevated levels of corticosterone in pups and impaired spatial learning and short- and long-term memory in late adolescent males and long-term memory in early adolescent females. There were sex differences in late adolescence in both learning and short-term memory. Performance on the long-term memory task was better than that on the short-term memory task for all early adolescent male and female control and stressed animals. Short-term memory was better in the late age control rats of both sexes and for formalin treated females as compared with the early age rats. These results are consistent with an impaired function of structures involved in memory (the hippocampus, amygdala, prefrontal cortex) after newborn pain. However, activation of the HPA axis by neonatal pain did not directly correlate with spatial learning and memory outcomes and the consequences of neonatal pain remain are likely multi-determined.

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“…It has been previously reported that deficiency of brain-derived neurotrophic factor (BDNF) levels was associated with the significantly impaired somatosensory behavior [51]. Interestingly, recent studies found that expression of BDNF was induced by EE [52,53], which maybe the mechanism underlying EE ameliorating somatosensory.…”

Section: Discussionmentioning

confidence: 99%

Environmental Enrichment Protects Against Cognition Deficits Caused by Sepsis-Associated Encephalopathy

Jiang

Zhao

Tang

et al. 2021

Preprint

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Background: Sepsis-associated encephalopathy (SAE) is a common complication of sepsis and characterized by impaired cognition ability in survivors. Previous studies revealed that environmental enrichment (EE) ameliorated the cognition deficits in different models of brain injury. However, little research exists exploring the effect of EE on SAE. Methods: our present study was designed to determine the possible benefits of EE in ameliorating the cognition deficits following SAE. To examine the benefits of EE, adult male rats with SAE were placed in an enriched environment or standard environment(SE) for 30 days. After the EE or SE housing, the rats were subjected to a behavioral test battery including sensory neglect test (SN), Elevated Plus Maze test (EPM), Open Field test (OF) Morris water maze test (MWM), and Novel Object Recognition test (NOR). Results: Our results showed that SAE-induced the impairment of recognition memory (NOR) and spatial learning and memory (MWM) was significantly inhibited in EE exposed rats. In addition, EE exposure also decreased the SAE-induced anxiety-like behavior (EPM) and increased exploratory activity (OF). However, no difference in locomotion ability was detected between the EE and SE exposed rats. Conclusions: Our results demonstrate the positive effect of EE on cognitive impairments after SAE. These results highlight the importance of environmental enrichment to prevent cognitive deficits induced by SAE.

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Postweaning Enriched Environment Enhances Cognitive Function and Brain-Derived Neurotrophic Factor Signaling in the Hippocampus in Maternally Separated Rats

Cited by 23 publications

References 49 publications

Quantitative susceptibility mapping shows lower brain iron content in children with attention‐deficit hyperactivity disorder

Quantitative susceptibility mapping shows lower brain iron content in children with attention‐deficit hyperactivity disorder

The Long-Term Effects of Neonatal Inflammatory Pain on Cognitive Function and Stress Hormones Depend on the Heterogeneity of the Adolescent Period of Development in Male and Female Rats

Environmental Enrichment Protects Against Cognition Deficits Caused by Sepsis-Associated Encephalopathy

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