Potassium canrenoate treatment in paediatric patients

Suyagh, Maysa; Hawwa, Ahmed F.; Collier, P. S.; Millership, Jeffrey S.; Kole, Prashant; Millar, Muriel; Shields, Michael; Halliday, Henry L.; McElnay, James

doi:10.1097/hjh.0b013e3283626994

Cited by 6 publications

(1 citation statement)

References 16 publications

(18 reference statements)

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“…To ensure adequate recovery of analyte from DBS, extensive mixing, agitation or sonication may be required 37 . The extract is centrifuged to remove any residues and an aliquot of it subjected to appropriate analytical technique for analysis or the extract taking through further sample cleanup steps such as solid phase and liquid-liquid extraction 92,93,23 or desalting and concentration using Millipore C18 Ziptip prior to analysis.…”

Section: Processing Of Dbs Samplesmentioning

confidence: 99%

Evaluation of paper spray mass spectrometry for direct analysis of small molecule drugs and hemoglobin constant spring peptide markers

Takyi-Williams¹

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Section: Processing Of Dbs Samplesmentioning

confidence: 99%

Evaluation of paper spray mass spectrometry for direct analysis of small molecule drugs and hemoglobin constant spring peptide markers

Takyi-Williams¹

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Dried Blood Spots Sampling and Population Pharmacokinetic Modeling for Dosing Optimization of Piperacillin in Chinese Neonates

Li,

Chen,

Chen

et al. 2024

The Journal of Clinical Pharma

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Piperacillin is commonly used off‐label in neonates for the treatment of bacterial infections. This study aimed to assess a dried blood spots (DBS)‐based microsampling strategy for supporting population pharmacokinetics and treatment optimization of piperacillin in Chinese neonates. DBS samples from neonatal patients were collected at predefined intervals. Drug blood concentrations were quantified using a validated ultra‐high‐performance liquid chromatography‐tandem mass spectrometry method. A population pharmacokinetic model was developed using a nonlinear mixed‐effects modeling approach. The pharmacokinetic/pharmacodynamics (PK/PD) target was 75% of the time with the unbound drug plasma concentration above the minimum inhibitory concentration (fT>MIC), with a toxicity threshold of unbound drug plasma trough concentration above 64 mg/L. A total of 45 piperacillin samples from 24 neonates were collected. The pharmacokinetics of piperacillin was described using a one‐compartment model with postmenstrual age (PMA) as the most significant covariate on clearance. Simulations showed that dosing regimens achieving >90% PK/PD target attainment with <10% risk of possible toxicity were: PMA 33‐35 weeks (50 mg/kg q12h), 35‐37 weeks (50 mg/kg q8h), and 37‐41 weeks (50 mg/kg q6h). In conclusion, Using DBS sampling, we developed a population pharmacokinetic model of piperacillin in Chinese neonates, incorporating PMA to determine optimal dosing regimens.

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Quantification of amlodipine in dried blood spot samples by high performance liquid chromatography tandem mass spectrometry

Chen

Jirjees

Bawab

et al. 2018

Journal of Chromatography B

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Potassium canrenoate treatment in paediatric patients

Cited by 6 publications

References 16 publications

Evaluation of paper spray mass spectrometry for direct analysis of small molecule drugs and hemoglobin constant spring peptide markers

Evaluation of paper spray mass spectrometry for direct analysis of small molecule drugs and hemoglobin constant spring peptide markers

Dried Blood Spots Sampling and Population Pharmacokinetic Modeling for Dosing Optimization of Piperacillin in Chinese Neonates

Quantification of amlodipine in dried blood spot samples by high performance liquid chromatography tandem mass spectrometry

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