1998
DOI: 10.1038/sj.bjp.0702232
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Potassium channel activation and relaxation by nicorandil in rat small mesenteric arteries

Abstract: 1 We used whole-cell patch clamp to investigate the currents activated by nicorandil in smooth muscle cells isolated from rat small mesenteric arteries, and studied the relaxant e ect of nicorandil using myography. 2 Nicorandil (300 mM) activated currents with near-linear current-voltage relationships and reversal potentials near to the equilibrium potential for K + . 3 The nicorandil-activated current was blocked by glibenclamide (10 mM), but una ected by iberiotoxin (100 nM) and the guanylyl cyclase inhibito… Show more

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Cited by 25 publications
(17 citation statements)
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“…In addition, comparative studies show that relaxation responses to nicorandil are inhibited significantly by the K ATP blocker GLM, but not by the other K + -channel blocker. These findings are in agreement with previous reports (43,44).…”
Section: Discussionsupporting
confidence: 83%
See 1 more Smart Citation
“…In addition, comparative studies show that relaxation responses to nicorandil are inhibited significantly by the K ATP blocker GLM, but not by the other K + -channel blocker. These findings are in agreement with previous reports (43,44).…”
Section: Discussionsupporting
confidence: 83%
“…These findings show that FLNT and nicorandil exhibit a dual mechanism of action acting partly as a nitrate and partly as a K + -channel opener. Our findings of two pathways for relaxation by nicorandil are consistent with two previous reports (43,44), while not consistent with other observations using piglet mesenteric arteries pre-contracted by noradrenaline (47). The reasons of the variable contribution of K ATP channel opening and stimulation of sGC on nicorandil-induced relaxation depend on the differences in the animal species, tissues, size of vessels, and agonist studied (48).…”
Section: Discussionsupporting
confidence: 82%
“…30 -32 In rat mesenteric arteries, small-conductance K ATP (K NDP ) channels (Ϸ25 pS, in symmetric high K ϩ ) have been identified that are regulated by nucleoside diphosphates (UDP or GDP) and ATP acting from the inside. 33,34 The molecular identity of the aortic and mesenteric K ATP channels is not absolutely established. Two Kir6.x subunits have been cloned to date: Kir6.1 and Kir6.2 that differ in their single channel conductance.…”
Section: Discussionmentioning
confidence: 99%
“…Nicorandil acts on both sarcolemmal and mito-KATP channels, 40 and also has a nitrate effect. 41 The effect of diazoxide was completely blocked by 5-HD, but its effect on nicorandil was not complete, as shown by Fig 4. This may be attributed to its combined effect, although it was small in the present study.…”
Section: Discussionmentioning
confidence: 99%