Potassium Channels in the Vascular Diseases

Zhu, Yanrong; Jiang, Xianzhen; Ye, Peng; Chen, Shao‐Liang; Zhang, Dai‐Min

doi:10.5772/intechopen.82474

Cited by 2 publications

(2 citation statements)

References 87 publications

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“…These two domains are responsible for the sensitivity of the BK Ca channels for Ca 2+ and Mg 2+ . While the RCK1 domain plays a role in the formation of the Ca 2+ -binding site, RCK2 contains an additional domain that binds Ca 2+ ions with very high affinity -Ca 2+ -bowl (43). Four pairs of RCK1 and RCK2 domains form the Ca 2+ -sensitive apparatus responsible for allosteric modification and activation of BK Ca channels upon Ca 2+ binding.…”

Section: Bk Ca Channelsmentioning

confidence: 99%

“…β subunits contain two, while γ subunits are constructed from a single transmembrane domain. The mechanism by which regulatory subunits interact with α subunits and regulate BK Ca channel activity is extremely complicated, but it is critical for the study and understanding of vascular disease (43,45). Theoretically, α subunits and regulatory β or γ subunits of BK Ca channels are found in a stoichiometric ratio of 1:1.…”

Section: Subtypes Of Potassium Channels In Smooth Muscle -K Ca Channelsmentioning

confidence: 99%

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Potassium channels on smooth muscle as a molecular target for plant-derived Resveratrol

Rajković

Djokic

Gostimirović

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a phytoalexin present in a variety of plant species. Resveratrol has a wide spectrum of pharmacologic properties, and it exhibits versatile biological effects on different human and animal models. The studies have shown that potassium (K) channels can be potential targets in the mechanism of resveratrol action. K channels play a crucial role in maintaining membrane potential. Inhibition of K channels causes membrane depolarization and then contraction of smooth muscles, while the activation leads to membrane hyperpolarization and subsequently, relaxation. Five diverse types of K channels have been identified in smooth muscle cells in different tissue: ATP-sensitive K channels (K ATP ), voltage-dependent K channels (Kv), Ca 2+ -and voltagedependent K channels (BK Ca ), inward rectifier K channels (Kir), and tandem two-pore K channels (K 2P ). The expression and activity of K channels altered in many types of diseases. Aberrant function or expression of K channels can be underlying in pathologies such as cardiac arrhythmia, diabetes mellitus, hypertension, preterm birth, preeclampsia, and various types of cancer. Modulation of K channel activity by molecular approaches and selective drug development may be a novel treatment modality for these dysfunctions in the future. The plant-derived non-toxic polyphenols, such as resveratrol, can alter K channel activity and lead to the desired outcome. This review presents the basic properties, physiological, pathophysiological functions of K channels, and pharmacological roles of resveratrol on the major types of K channels that have been determined in smooth muscle cells.

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Section: Bk Ca Channelsmentioning

confidence: 99%

Section: Subtypes Of Potassium Channels In Smooth Muscle -K Ca Channelsmentioning

confidence: 99%

Potassium channels on smooth muscle as a molecular target for plant-derived Resveratrol

Rajković

Djokic

Gostimirović

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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Allisartan ameliorates vascular remodeling through regulation of voltage-gated potassium channels in hypertensive rats

Zhang

Zhao

et al. 2021

BMC Pharmacol Toxicol

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Background The objective of the present study was to determine the effect of allisartan, a new angiotensin II type 1 receptor antagonist on vascular remodeling through voltage gated potassium channels (Kv7) in hypertensive rats. Methods The study included a total of 47 Sprague Dawley (SD) rats. The animals were randomized to sham operation (n = 14), untreated hypertensive control group (n = 18) and allisartan treatment group (n = 15). Using renal artery stenosis, hypertension was induced in animals. Single dose of allisartan was administered intra-gastrically to animals in the allisartan treatment group and match placebo in the other 2 groups. Wire myography was used to measure the muscle tension in isolated mesenteric arteries from the animals. Real-time polymerase chain reaction was used to quantify the expression of Kv7 channel mRNA subunits. Results After 4 weeks of treatment, a significant decrease in mean arterial, systolic and diastolic blood pressure (SBP and DBP) was observed in allisartan treatment group compared to hypertension control group. The median arterial wall thickness and area/diameter ratio reduced significantly in treatment group compared to untreated hypertension group (P < 0.05). Wire myography demonstrated increased relaxation of mesenteric artery with increase in concentration of ML213. A significant up-regulation in the expression of all Kv7 mRNA subunits was observed in allisartan group compared to untreated hypertension group. Conclusions From the results, allisartan was found to lower BP and preserve vascular remodeling through Kv7 channels.

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Potassium Channels in the Vascular Diseases

Cited by 2 publications

References 87 publications

Potassium channels on smooth muscle as a molecular target for plant-derived Resveratrol

Potassium channels on smooth muscle as a molecular target for plant-derived Resveratrol

Allisartan ameliorates vascular remodeling through regulation of voltage-gated potassium channels in hypertensive rats

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