Potassium Dichromate Toxicities: Protective Effect of Methanol Extract of Corchorus olitorius in Albino Rats

Abstract

Exposure to hexavalent chromate compounds such as other human carcinogens is unavoidable in the developing countries of the world. Research efforts are being directed toward minimizing exposure to them, intercepting their activity in vivo, and/or prophylaxis. The present study therefore evaluates the effect of methanol extract of the leafy vegetable, Corchorus olitorius (MECO), against potassium dichromate (K2Cr2O7)-induced toxicities. Negative control animals were fed distilled water, while the positive control rats received 12 mg/kg body weight K2Cr2O7 once a week for 6 weeks. Test rats were exposed daily to 25, 50, and 100 mg/kg body weight MECO alone for 6 weeks and 12 mg/kg body weight of K2Cr2O7 once a week for 6 weeks before sacrifice. The frequency of micronucleated polychromatic erythrocytes (mPCEs) was monitored in bone marrow cells, while induction of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine levels, and hematological parameters were assessed in the plasma. The phytochemical analysis of MECO was also carried out. K2Cr2O7 significantly (P < .05) increased the levels of mPCEs, AST, ALT, creatinine, total white blood cells, and lymphocytes compared with the control. The percentage pack cell volume and neutrophils were, however, reduced. In contrast, MECO at different doses restored the markers toward the levels of the negative control. MECO is rich in flavonoids, saponins, anthraquinones, terpenoids, and phenols, and they might be responsible for the protective effect observed in this study. Our results suggest that MECO has a promising potential in the treatment/management of chromate-induced toxicities.

Toxicological Outcome of Combined Exposure to Potassium Dichromate and Levonorgestrel in the Kidney of Female Rats

“…In fact, oxidative stress could have led to the renal damage observed in this study. Lesion observed in the kidney of the group treated with PDC are similar to our earlier observation [25] and that of others [10][11]. Moreover, levonorgestrel impairs energy metabolism and microsomal electron transportation in the proximal tubules and other parts of the nephron [4], which may also explain the tubular epithelial degeneration and necrosis observed in the levonorgestrel-treated group in this study.…”

Modification of Hexavalent Chromate Hepatotoxicity by Ethanol Extract of Moringa oleifera in Wistar Rats

“…This result is in agreement with earlier findings in our laboratory and those of others researchers. 18,36 However, EEMO treatment improved the liver function by decreasing the elevated serum ALT and AST caused by K 2 Cr 2 O 7 administration. Aqueous extract of Moringa oleifera has been reported to protect the liver against rifampicin and isoniazid induced hepatic damage.…”

“…Both K 2 Cr 2 O 7 and EEMO were dissolved in deionized water and doses were selected based on our previous study and dose cited in literature. [18][19][20] The negative control rats were fed distilled water throughout the experiment, while the positive control rats were intraperitoneally injected with 12 mg/kg body weight K 2 Cr 2 O 7 once per week. Twenty-four hours after the last treatment, the final body weights of the animals were obtained and blood samples were collected from the retro-orbital plexus of each rat directly into heparinized tubes.…”

Wavelength selective photoactivated autocatalytic oxidation of 5,12-dihydrobenzo[b]phenazine and its application in metal-free synthesis

“…12 The accumulation of Cr(VI) in the human body can lead to many diseases, such as skin allergy, kidney disease and cancer. 13 Therefore, it is of great signicance to develop metal-free green synthesis methods for the oxidation of the H 2 -NHAs.…”