Potassium Metabolism in Chronic Kidney Disease

Palmer, Biff F.

doi:10.1016/b978-0-12-411602-3.00032-9

Cited by 4 publications

(3 citation statements)

References 55 publications

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“…Notably, TSH production increases appropriately in response to thyroid ablation. This latter response holds clinical significance, particularly since TSH levels should rise in uremic patients developing hypothyroidism [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring Thyroid Function after Kidney Transplantation: The Complex Interplay Unacknowledged in Post-Transplant Care

Jelić Pranjić,

Orlić,

Carević

et al. 2024

JCM

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Background/Objectives: The interplay between thyroid function and kidney graft function following kidney transplantation remains incompletely understood. Thyroid disorders are more prevalent in kidney transplant recipients than in the general population and are associated with poorer outcomes. Methods: This prospective, single-center study was designed to estimate thyroid function (thyroid-stimulating hormone (TSH), triiodothyronine (T3), free triiodothyronine (FT3), thyroxine (T4), free thyroxine (FT4), as well as anti-thyroid peroxidase antibody (anti-TPO), anti-thyroglobulin antibody (anti-Tg), and thyroid-stimulating immunoglobulin (TSI)) and its influence on kidney graft function among a cohort of 23 kidney transplant recipients during a follow-up period of 12 months. Results: Significantly increased levels of T4 and T3 were observed 12 months post-transplantation, with FT3 levels increasing significantly after 6 months. The prevalence of immeasurably low anti-Tg antibodies rose during follow-up. Initially, 8% of patients showed positive TSI, which turned negative for all after 6 months. A statistically significant correlation was found between the initial TSH and the estimated glomerular filtration rate (eGFR) value 6 months after transplantation (p = 0.023). The graft function was stable. Proteinuria was statistically significantly lower 12 months after transplantation. Conclusions: Identifying additional risk factors, understanding their impact on kidney graft function, and recognizing cardiovascular comorbidities could enhance patient care. Notably, this study marks the first prospective investigation into thyroid function after kidney transplantation in Croatia, contributing valuable insights to the global understanding of this complex interplay.

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Section: Discussionmentioning

confidence: 99%

Exploring Thyroid Function after Kidney Transplantation: The Complex Interplay Unacknowledged in Post-Transplant Care

Jelić Pranjić,

Orlić,

Carević

et al. 2024

JCM

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“…From this rate of renal clearance, it can be calculated that 6 to 8 units of insulin are degraded by the kidney each day, which accounts for approximately 25 percent of the daily production of insulin by the pancreas. The contribution of renal metabolism is enhanced in diabetic subjects receiving exogenous insulin since injected insulin enters the systemic circulation directly, without first passing through the liver [12].…”

Section: Normal Renal Handling Of Insulinmentioning

confidence: 99%

Carbohydrate Metabolism in Chronic Kidney Disease

Bhattacharya¹

2018

JOJUN

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Insulin resistance (IR) is a common feature of chronic kidney disease (CKD), but the exact underlying mechanism is still an enigma. Studies have shown that IR and the associated altered metabolic milieu, even in the absence of Diabetes is an important contributory factor to the development of cardiovascular disease in CKD. There is growing evidence that modification of intestinal flora and activation of immuneinflammatory pathways which have been implicated in the pathogenesis of IR in obese and diabetic patients. All these pathways ultimately lead to ectopic lipid accumulation with impaired insulin signalling. Indeed, recent studies show impaired intestinal barrier function and altered gut microbiome in non-diabetic patients with CKD that can contribute to the prevailing inflammation, and the production and absorption of toxins generated from bacterial metabolism. The specific role of individual uremic toxins in the pathogenesis of IR has been highlighted in rodents. Moreover, correcting some uraemia-associated factors by modulating the intestinal flora improve insulin sensitivity.

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“…Chinese studies on large cohorts demonstrated that corticoid activity is negatively associated with the glomerular filtration rates, and positively with serum creatinine, as its levels continuously increase with the progression of chronic kidney disease [34]. Other studies found low cortisol levels in haemodialysis patients, but significantly high levels of cortisol metabolites (tetrahydrocortisol, 5α-tetrahydrocortisol and tetrahydrocortisone) with toxic effects; high cortisol levels in end stage renal disease were associated with inflammation and increased mortality risk [35][36][37][38]. It is certain that the sustained treatment of any inflammatory trigger, the preservation of a healthy vascular access and a good nutrition status without hypoglycaemic events can contribute to maintain normal cortisol levels in dialysis population and ameliorates cardiovascular risks [39].…”

Section: Biochemical Components Involved In Modulating the Impulsive Behaviour -Specific Changes In Chronic Dialysis Patientsmentioning

confidence: 99%

Untitled

2018

FARMACIA

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Violence and aggression are among the most important problems of the contemporary world. Modern humanity vices, like alcohol, drug abuse, daily stress, but also specific therapies within the positive tendency to prolong life in severe chronic diseases seems to contribute to the ascending trend of aggressive behaviour. A topic of debate is the ability of chronic kidney disease and its treatment to induce biochemical and behavioural changes that predispose to impulsivity. The answer can reveal treatment adjustments (chemical, procedural and psychological) that can be made for improving behavioural condition and the quality of life in these patients. RezumatViolența și tendința la agresivitate reprezintă unele dintre cele mai importante probleme cu care se confruntă societatea contemporană. Amploarea în creștere a fenomenului pare a fi determinată nu numai de viciile lumii moderne (abuzul de alcool și droguri, stresul cotidian), ci și de efectele anumitor terapii menite a prelungi durata de viață în afecțiuni severe infirmizante. Un subiect actual de dezbatere este reprezentat de influența bolii cronice de rinichi și a tratamentului prin hemodializă asupra bazelor biochimice ale agresivității. Elucidarea mecanismelor prin care această afecțiune ar putea favoriza (la nivel chimic, procedural sau psihologic) tendințele impulsive ale individului ar permite modificări terapeutice care să amelioreze problemele comportamentale și calitatea vieții pacientului.

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Potassium Metabolism in Chronic Kidney Disease

Cited by 4 publications

References 55 publications

Exploring Thyroid Function after Kidney Transplantation: The Complex Interplay Unacknowledged in Post-Transplant Care

Exploring Thyroid Function after Kidney Transplantation: The Complex Interplay Unacknowledged in Post-Transplant Care

Carbohydrate Metabolism in Chronic Kidney Disease

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