The imbalanced use of fertilizers and irrigation water, particularly supplied from groundwater, has adversely affected crop yield and harvest quality in sugarcane (Saccharum officinarum L.). In this experiment, we evaluated the impact of potassium (K) and micronutrients [viz. Zinc (Zn), Iron (Fe), and Boron (B)] application and irrigation water from two sources, viz. canal, and tube well water on sugarcane growth, yield, and cane quality under field trails. Water samples from Mardan (canal water) and Rahim Yar Khan (tube well water) were analyzed for chemical and nutritional attributes. The results revealed that tube well water’s electrical conductivity (EC) was three-fold that of canal water. Based on the EC and total dissolved salts (TDS), 83.33% of the samples were suitable for irrigation, while the sodium adsorption ratio (SAR) indicated only a 4.76% fit and a 35.71% marginal fit compared with canal water. Furthermore, the application of K along with B, Fe, and Zn had led to a significant increase in cane height (12.8%, 9.8%, and 10.6%), cane girth (15.8%, 15.6%, and 11.6%), cane yield (13.7%, 12.3%, and 11.5%), brix contents (14%, 12.2%, and 13%), polarity (15.4%, 1.4%, and 14%), and sugar recovery (7.3%, 5.9%, and 6%) in the tube well irrigation system. For the canal water system, B, Fe, and Zn increased cane height by 15.3%, 13.42%, and 11.6%, cane girth by 13.9%, 9.9%, and 6.5%, cane yield by 42.9%, 43.5%, and 42%, brix content by 10.9%, 7.7%, and 8%, polarity by 33.4%, 28%, and 30%, and sugar recovery by 4.0%, 3.9%, and 2.0%, respectively, compared with sole NPK application. In conclusion, the utilization of tube well water in combination with canal water has shown better results in terms of yield and quality compared with the sole application of canal water. In addition, the combined application of K and B significantly improved sugarcane yields compared with Zn and Fe, even with marginally suitable irrigation water.