Potassium Tolerance in Rats

Wr, Adam; Dawborn, J K

doi:10.1038/icb.1972.69

Cited by 29 publications

(11 citation statements)

References 3 publications

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“…Alexander and Levinsky [1968] were able to confirm that in the potassium-adapted rat, increased urinary excretion of potassium could occur but extra-renal uptake of the ion was also increased and the adaptation was suggested to be due to enhanced potassium uptake by more than one tissue in response to chronically high mineralocorticoid levels. In a later study the increased ability of potassium-tolerant rats to excrete potassium in the urine was associated with evidence of increased mineralocorticoid activity but the extra-renal component of potassium adaptation was not confirmed [Adam and Dawborn, 1972]. The changing response of the adrenalectomized sheep to the infusion of potassium had a number of features which were similar to potassium adaptation in the rat and dog.…”

Section: Discussionmentioning

confidence: 55%

Changes in Renal Haemodynamics and Electrolyte Excretion During Acute Hyperkalaemia in Conscious Adrenalectomized Sheep

et al. 1975

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The p-aminohippurate (PAH) clearance, inulin clearance and the excretion of electrolytes by 10 adrenalectomized sheep were measured before, during and after the infusion of 0*43 M-KCl at 2 ml./min for 2 hr. The PAH clearance increased as the plasma potassium concentration increased up to approximately 6'0 m-mole/l. Further increases in plasma potassium were associated with a progressive return of the PAH clearance to or below the pre-infusion levels. At its maximum the PAH clearance was 1-228 ±0-032 (S.E. of mean) times the pre-infusion levels. The inulin clearance increased to reach a maximum coincident with or subsequent to the maximum PAH clearance. The maximum level ofinulin clearance during the hyperkalaemia was 1 158 ±0-020 times the pre-infusion clearance. The increments in the clearance of potasium and of bicarbonate rose rapidly to exceed the increment in inulin clearance during the hyperkalaemia in all experiments. The increments in the clearance of sodium and of chloride exceeded the increment in inulin clearance in more than half the experiments. It was concluded that although hyperkalaemia was associated with increased glomerular filtration much of the increased excretion of sodium, chloride and bicarbonate was derived from depressed tubular reabsorption of the ions. When the infusion experiments were repeated on the same animals the sheep demonstrated an improved ability to control the rise in plasma potassium concentration which was similar to potassium adaptation described in other species. There were no apparent differences between sheep maintained on 1*5 mg and 5 mg deoxycorticosterone acetate daily in their adaptation to potassium loading and the effect was tentatively attributed to the level of steroid maintenance being chronically high. The toxicity of hyperkalaemia was not lessened by this adaptation to potassium loading.

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Section: Discussionmentioning

confidence: 55%

Changes in Renal Haemodynamics and Electrolyte Excretion During Acute Hyperkalaemia in Conscious Adrenalectomized Sheep

et al. 1975

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“…After a chronic increase in dietary potassium intake, a sequence of adaptive changes takes place in the kidneys that lead to the more effective and enhanced excretion of potassium after an acute potassium load (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). This response, called potassium adaptation, is associated with a sharp elevation of plasma aldosterone levels and with an increase in potassium secretion by the initial collecting, cortical collecting, and medullary collecting tubules (1-3, 11, 12, 17-21).…”

Section: Introductionmentioning

confidence: 99%

Independent effects of aldosterone and potassium on induction of potassium adaptation in rat kidney.

Stanton¹,

Pan²,

Deetjen³

et al. 1987

J. Clin. Invest.

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We examined the independent effects of a high potassium diet and increased aldosterone levels on the development of renal potassium adaptation. This condition is defined by the increased ability of the kidneys to excrete an acute infusion of potassium. Rats were adrenalectomized (ADX) and received aldosterone at basal levels (0.5 Asg/100 g * d) or at high levels (2.0 ;g/100 go d) for 10 d. In each experimental group, animals received either a control diet or a high potassium diet. In ADX animals with basal aldosterone levels, a high potassium intake increased but did not completely restore the ability to excrete potassium and induced proliferation of the basolateral membrane of principal cells in the collecting tubule (i.e, morphologic adaptation). In contrast, increased aldosterone did not induce functional adaptation. Elevated aldosterone and dietary potassium intake were required to produce functional potassium adaptation indistinguishable from that in potassium-loaded, adrenal-intact animals.

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“…The experiments were carried out in conscious, unrestrained animals after a 16-20 h fast. At this time there is no detectable difference in plasma electrolyte status of CK and HK rats (Adam & Dawborn 1972).…”

Section: Methodsmentioning

confidence: 91%

“…Whilst there is some evidence for an adaptation in K excretion independent of adrenal steroids (Wingo et al 1982), prior adrenalectomy obliterates most of the adaptive process (Adam & Dawborn 1972;Adam, Goland & Wellard 1984). More recently we have shown that the greater part of the kaliuretic adaptation relates to adrenal steroids, both mineralocorticoids and glucocorticoids (Adam et a/ 1984).…”

Section: Introductionmentioning

confidence: 94%

Plasma Aldosterone Levels After Kci Loading in Rats Adapted to a High Potassium Diet

Adam

Campbell

1984

Clin Exp Pharma Physio

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Plasma levels of aldosterone, corticosterone, potassium and renin activity, and urinary potassium excretion, were measured in control (CK) rats, and in rats adapted to a high potassium diet (HK), before and after an acute intragastric KCl load. Prior to the KCl load there was no difference in plasma potassium (K) or plasma aldosterone. Following the KCl load, HK rats maintained a lower plasma K, and, except at 30 min after the load, a lower plasma aldosterone than CK rats. At a low plasma K there was no difference in plasma aldosterone between CK and HK rats. At a high plasma K (greater than 8 mmol/l) the HK rats had a higher plasma aldosterone for the same plasma K than CK rats. The enhanced ability to excrete an acute K load seen in HK rats seems unlikely to be due to higher levels of plasma aldosterone.

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Potassium Tolerance in Rats

Cited by 29 publications

References 3 publications

Changes in Renal Haemodynamics and Electrolyte Excretion During Acute Hyperkalaemia in Conscious Adrenalectomized Sheep

Changes in Renal Haemodynamics and Electrolyte Excretion During Acute Hyperkalaemia in Conscious Adrenalectomized Sheep

Independent effects of aldosterone and potassium on induction of potassium adaptation in rat kidney.

Plasma Aldosterone Levels After Kci Loading in Rats Adapted to a High Potassium Diet

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