Potassium transport in the distal tubule and collecting duct of the rat

Reineck, H. J.; Osgood, RW; Tf, Ferris; Stein, Julia

doi:10.1152/ajplegacy.1975.229.5.1403

Cited by 26 publications

(22 citation statements)

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“…Borenstein et al (1983) reported that injection of atrial extract into anesthetized rats increased total and medullary blood flow in the kidney. In the present study, the prolonged kaliuresis was accompanied by the diuresis, which suggests that urine flow into the distal tubule may have increased after the injection of a-hANP, since it has been shown that potassium secretion is increased when flow into the distal tubule is increased (Malnic et al 1966;Morgan and Berliner 1969;Kunau et al 1974; Khuri et al 1975;Reineck et al 1975;Diezi et al 1976). This increase in urine flow into the distal tubule could have been elicited by the dissipation of corticomedullary osmotic gradient by medullary washout.…”

Section: Resultssupporting

confidence: 58%

The effects of intravenous injection of .ALPHA.-human atrial natriuretic polypeptide on blood pressure, renal hemodynamics and urinary kinin excretion in anesthetized rabbits.

Nushiro

Abe

Seino

et al. 1987

Tohoku J. Exp. Med.

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Studies were performed in anesthetized rabbits to examine the effects of a-human atrial natriuretic polypeptide (a-hANP) on blood pressure, renal hemodynamics and urinary kinin excretion. Intravenous bolus injection of a-hANP at a dose of 5pg resulted in a transient increase in renal blood flow from 26.6+2.2 to 33.7+2.2 ml/min (p <0.05) and a decrease in mean arterial pressure from 113+1.8 to 107±2.2mmHg (p< 0.01). The calculated renal vascular resistance decreased from 4.50+0.34 to 3.28+0.20 mmHg/ml/min (p <0.05). This vasodilatory effect of a-hANP was immediate and lasted for 30 min. These hemodynamic alterations were not associated with the changes in glomerular filtration rate estimated by creatinine clearance. Intravenous injection of a-hANP also produced marked increases in urine volume from 1.99+0.43 to 5.7+1.20 ml 10 min (p <0.01), urinary sodium from 42.2± 7.6 to 243±54 ,u Eq/ 10 min (p <0.01), urinary potassium from 37.5± 5.5 to 74.8± 10.3 ,u Eq/ 10 min (p <0.01), and urinary kinin excretion from 3.44± 0.49 to 5.26±0.82 ng/ 10 min (p <0.05). The observed natriuretic effect of ahANP lasted only for 30 min, whereas diuretic and kaliuretic effects were sustained for 120 min. Hematocrit levels did not change significantly throughout the experiment. These results indicate that a-hANP is a potent vasodilator substance and that the natriuretic effect induced by the bolus injection of a-hANP is mediated mainly through its renal vasodilatory action. It is also suggested that the renal kinin, at least in part, contributes to the natriuretic effect of a-hANP. a-human atrial natriuretic polypeptide (a-hANP) ; renal hemodynamics ; fluid and electrolyte excretion ; urinary kinin excretion It is well informed that mammalian atrial extract when administered to rats produces a marked natriuresis and diuresis (de Bold et al. 1981;

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Section: Resultssupporting

confidence: 58%

The effects of intravenous injection of .ALPHA.-human atrial natriuretic polypeptide on blood pressure, renal hemodynamics and urinary kinin excretion in anesthetized rabbits.

Nushiro

Abe

Seino

et al. 1987

Tohoku J. Exp. Med.

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“…Similar findings have also been described previously by Merlet-Benichou and de Rouffignac (20) in near-term fetal guinea pigs. These authors suggested that the increascd ability of thc fetal kidncy to cxcrctc morc potassium as gcstation advanced was a flow-dependent phenomenon as described in adult animals (10,24,38 ). However, in the present study there was no significant correlation between fetal urinary flow rate and fractional excretion of potassium (r = -0.18) suggesting that in chronically catheterized fetal lambs, urinary flow rate does not play an important role in the maturation process of potassium excretion.…”

Section: Discussioncontrasting

confidence: 53%

Role of Aldosterone on Renal Sodium and Potassium Excretion during Fetal Life and Newborn Period

Robillard¹,

Ramberg²,

Sessions³

et al. 1980

Dev Pharmacol Ther

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The renal response to endogenous aldosterone production at different times during gestation and immediately after birth, as well as factors controlling aldosterone secretion during fetal life have been studied in 34 lamb fetuses (106-142 days of gestation, term 145 days) and in 6 newborn lambs (3-8 days postnatal age). lt was demonstrated that the increase in fetal plasma aldosterone concentration correlated with the increase in fetal plasma renin activity (PRA) (r = 0.67, p < 0.001). Moreover, it was found that the slope of the regression line between plasma aldosterone and PRA during fetal life was significantly steeper (p < 0.05) than after birth. Significant correlation coefficients were found between the fetal urinary to plasma ratios (U/P) of sodium over potassium [(U/P)Na+/(U/P)K+J and either fetal plasma aldosterone (r = 0.53, p < 0.005) or fetal age (r = - 0.5 2, p < 0.005 ). Moreover, in 7 out of 9 fetuses over 125 days, frank secretion of potassium by the fetal tubular cells was demonstrated; such a secretion was present in only 1 of the 15 fetuses between 101 and 125 days of gestation. Finally , it was demonstrated that the increase in mean arterial blood pressure during fetal life and after birth is not a major Iactor in thc increase in fetal glomerular filtration rate during gestation or in the adaptation of glomerular filtration rate to extrauterine life.

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“…Beck et al (51) have reported that ACZ did not change fractional reabsorption of K in the proximal tubule. In addition it is generally accepted that the bulk of urinary K is derived from a distal secretory process (40,52,53) and that K secretion is dependent upon urinary flow rate, per se (54)(55)(56). Fig.…”

Section: Resultsmentioning

confidence: 99%

Effects of Acetazolamide on Proximal Tubule Cl, Na, and HCO3 Transport in Normal and Acidotic Dogs during Distal Blockade

Chou¹,

Porush²,

Slater³

et al. 1977

J. Clin. Invest.

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A B S T R A C T It has been suggested that the establishment of a tubular fluid to plasma chloride gradient in the late proximal tubule by the reabsorption of bicarbonate (and other anions) in the early proximal tubule is responsible for a significant part of sodium chloride and water reabsorption in the proximal tubule. In the present study the effects of acetazolamide on proximal tubule water and electrolyte excretion were examined in 6 normal dogs and 10 chronic ammonium chloride-loaded dogs during distal blockade produced by ethacrynic acid and chlorothiazide administration. During distal blockade control urine/plasma osmolality and urine/plasma sodium were close to unity in all experiments. Urine/plasma chloride and urine/plasma bicarbonate were 1.21+0.02 and 0.75+0.07 in normal and 1.24+0.01 and 0.04+0.01 in acidotic dogs, respectively. After the administration of acetazolamide (20 mg/kg i.v.), there was a significant increase in urine flow, absolute and fractional excretion of sodium, bicarbonate, and chloride in all animals. Associated with these effects, urine/plasma osmolality and urine/ plasma sodium remained unchanged but urine/plasma chloride decreased significantly to 1.15±0.01 in normal and to 1.19+0.01 in acidotic dogs. In acidotic dogs there was a significant correlation between the increase in bicarbonate, sodium, or chloride excretion after acetazolamide and the plasma bicarbonate level (range 6.8-12.5 meq/liter). These data demonstrate a significant effect of acetazolamide on bicarbonate, sodium, and chloride reabsorption in the proximal tubule even in the face of severe acidosis. Moreover, the data suggest that the decrease in chloride reabsorption (and accompanying sodium) after acetazolamide is related to the decrease in bicarbonate reabsorption and the associated decrease in the transtubular chloride gradient.

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Potassium transport in the distal tubule and collecting duct of the rat

Cited by 26 publications

References 0 publications

The effects of intravenous injection of .ALPHA.-human atrial natriuretic polypeptide on blood pressure, renal hemodynamics and urinary kinin excretion in anesthetized rabbits.

The effects of intravenous injection of .ALPHA.-human atrial natriuretic polypeptide on blood pressure, renal hemodynamics and urinary kinin excretion in anesthetized rabbits.

Role of Aldosterone on Renal Sodium and Potassium Excretion during Fetal Life and Newborn Period

Effects of Acetazolamide on Proximal Tubule Cl, Na, and HCO3 Transport in Normal and Acidotic Dogs during Distal Blockade

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