Potato phenolics impact starch digestion and glucose transport in model systems but translation to phenolic rich potato chips results in only modest modification of glycemic response in humans

Moser, Sydney; Aragon, Ingrid; Furrer, Amber; Klinken, Jan-Willem van; Kaczmarczyk, Melissa; Lee, Byung‐Hoo; George, Judy; Hamaker, Bruce R.; Mattes, Richard D.; Ferruzzi, Mario G.

doi:10.1016/j.nutres.2018.02.001

Cited by 34 publications

(21 citation statements)

References 52 publications

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“…For acute glucose metabolism, 16 studies reported a measure of postprandial glucose, 13 of which calculated an incremental area under the curve (IAUC) [29,30,31,34,35,36,38,40,41,42,43,44,45], while three of them evaluated the effect at various postprandial time points [37,39,46]. Of the 13 reporting an IAUC, only two reported a significant reduction in IAUC for glucose after a HCA-rich intervention compared to a control [36,44], whereas one study demonstrated an increase [43]. One of these two studies [36], conducted on 12 healthy young adults, found a significantly lower 2 h IAUC for glucose after consumption of 25 g sucrose with coffee enriched with GCE and containing ~432 mg CGAs, compared to 25 g sucrose in water.…”

Section: Resultsmentioning

confidence: 99%

“…However, there was no effect when sucrose was consumed with normal or decaffeinated instant coffee containing ~220 mg CGAs [36]. The second study [44] was conducted in 12 healthy young adults who consumed one of three potato chips (from red, purple or white potatoes) containing up to ~360 mg CGAs and providing 50 g of available carbohydrates and compared to the consumption of 50 g available carbohydrates from plain salted wheat crackers. The 2 h IAUC for glucose was significantly lower after each of the potato chips compared to the cracker control.…”

Section: Resultsmentioning

confidence: 99%

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Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability

et al. 2019

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Plant-based diets rich in bioactive compounds such as polyphenols have been shown to positively modulate the risk of cardiometabolic (CM) diseases. The inter-individual variability in the response to these bioactives may affect the findings. This systematic review aimed to summarize findings from existing randomized clinical trials (RCTs) evaluating the effect of hydroxycinnamic acids (HCAs) on markers of CM health in humans. Literature searches were performed in PubMed and the Web of Science. RCTs on acute and chronic supplementation of HCA-rich foods/extracts on CM biomarkers were included. Forty-four RCTs (21 acute and 23 chronic) met inclusion criteria. Comparisons were made between RCTs, including assessments based on population health status. Of the 44 RCTs, only seven performed analyses on a factor exploring inter-individual response to HCA consumption. Results demonstrated that health status is a potentially important effect modifier as RCTs with higher baseline cholesterol, blood pressure and glycaemia demonstrated greater overall effectiveness, which was also found in studies where specific subgroup analyses were performed. Thus, the effect of HCAs on CM risk factors may be greater in individuals at higher CM risk, although future studies in these populations are needed, including those on other potential determinants of inter-individual variability. PROSPERO, registration number CRD42016050790.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability

et al. 2019

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“…Polyphenols are primarily obtained from cereals, fruits, vegetables and beverages such as tea, coffee and wine and include anthocyanins from berry fruits, flavanones from citrus fruits, flavonols from apples and phenolic acids from cereals (Bordenave et al, 2014;Rasouli et al, 2017;Li et al, 2017). Research advances have indicated that polyphenols can inhibit either starch hydrolyzing enzymes in the mouth and small intestines or glucose transporter residing on brush border membranes thereby reducing the amount of glucose in blood circulation (Johnston et al, 2002;Moser et al, 2018). Inhibition of starch digestion enzymes has sparked great interest in managing postprandial blood glucose as prolonged elevated blood glucose is characteristic or predisposing factor to diabetes.…”

Section: Introductionmentioning

confidence: 99%

Polyphenolic inhibition of enterocytic starch digestion enzymes and glucose transporters for managing type 2 diabetes may be reduced in food systems

Ayua

Nkhata

Namaumbo

et al. 2021

Heliyon

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With the current global surge in diabetes cases, there is a growing interest in slowing and managing diabetes and its effects. While there are medications that can be used, they have adverse side effects such as hypoglycemia and weight gain. To overcome these problems, bioactive compounds commonly found in fruits, vegetables and cereal grains are used to slow starch digestion and transport of simple sugars across the intestinal epithelia thereby reducing plasma blood glucose spike. These effects are achieved through inhibition of amylases, glucosidases and glucose transporters present in the gastrointestinal tract and brush boarder membrane. The extent of inhibition by polyphenols is dependent on molecular structure, doses and food matrix. Glycemic lowering effect of polyphenols have been demonstrated both in in vivo and in vitro studies. However, when these compounds are incorporated in food systems, they can interact with other polymers in the food matrix leading to lesser inhibition of digestion and/or glucose transporters compared to isolated or pure compounds as often witnessed in most in vitro studies.

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“…Other types of flavonoids include catechin, epicatechin, erodictyol, kaempeferol, quercetin, naringenin, and rutin [4]. According to Moser et al [12], colored potatoes can provide up to 20 mg of phenolics per serving, thus making them one of the prominent sources of polyphenols in the diet.…”

Section: Introductionmentioning

confidence: 99%

Effect of Different Solvents on the Extraction of Phytochemicals in Colored Potatoes

Thomas¹,

Barley²,

Willis³

et al. 2020

FNS

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Colored potatoes are an interesting alternative to the traditional, white-creamed potatoes, due to their high phytochemical content, which have been proved to have antioxidative properties. The extraction of polyphenols is highly dependent on using the appropriate solvent systems. Therefore, polyphenol extraction in colored potatoes [Vermillion Fingerling (VF); Jester Potato (JP); Magic Molly (MM); Blue Belle (BB); All Blue (AB)] using different solvents [Solvent A (24% water, 67% ethanol 9% acetic acid); Solvent B (5% acetic acid); and Solvent C (95% water, 5% acetic acid, 0.5 g sodium bisulfate)] may have significant effects on extraction efficiency and phytochemical content. Total phenolic content (TPC), Total flavonoid content (TFC), Total anthocyanin content (TAC) and antioxidant activities [Trolox Equivalent Antioxidant Capacity (TEAC) and Ferric reducing-antioxidant power (FRAP)] were determined. Solvent A extracted significantly (p < 0.05) higher TPC from BB (13.93 mg GAE/100g) compared to the other solvents. VF and JP displayed higher TFC (14.53 and 19.46 mg CE/100g, respectively) when Solvent C was utilized. VF and JP extracts with Solvent C displayed the highest FRAP value compared to Solvent B. MM displayed the highest TAC using Solvent A and C. Potato variety resulted in high variability in polyphenols content and antioxidant activity. The utilization of colored potatoes or extracts in the food industry could provide innovative products and a functional alternative to the traditional.

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Potato phenolics impact starch digestion and glucose transport in model systems but translation to phenolic rich potato chips results in only modest modification of glycemic response in humans

Cited by 34 publications

References 52 publications

Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability

Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability

Polyphenolic inhibition of enterocytic starch digestion enzymes and glucose transporters for managing type 2 diabetes may be reduced in food systems

Effect of Different Solvents on the Extraction of Phytochemicals in Colored Potatoes

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