Chemical control of potato wart disease was investigated during the spread of the disease in the first three decades of this century. The principal areas of investigation were the UK and the USA. In UK, protection was attempted but was largely unsuccessful. In USA, the strategy was that of eradication and succeeded through the massive use of toxic chemicals. Protection appeared to fail because of insufficient knowledge of the biology of the causal agent and the inability to target chemicals successfully. In all, over 600 treatments were found in the literature, and included more than 110 inorganic, organic and proprietary compounds. On the basis of this review, a proposal is made to use biological means for control.