2016
DOI: 10.1017/s1431927616000325
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Potencial Anti-inflamatory Effects of Artemisia Gorgonum on Rat Liver Injury Induced by CCl4

Abstract: Artemisia gorgonum (Asteraceae) is a common traditional Cape Verde medicinal plant which has been used intensively to treat several inflammatory diseases. However, the most recent studies reported the antimalaria activity [1] , antiviral, anti-tumoral, anti-pyretic, anti-hemorrhagic, anti-coagulant, anti-fungal, antimicrobial, anti-oxidant, anti-malarial, anti-ulcerogenic and antispasmodic and hepatoprotective activities have been reported for the Artemisia genus [1][2][3][4][5] . Therefore, our aim is to inv… Show more

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Cited by 3 publications
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“…However, for many plants, their mechanism of action against hepatotoxic agents is not well‐documented. The common prototype applied for hepatoprotective drug screening is the carbon tetrachloride (CCl 4 ) induced hepatic injury (Rodrigues et al, ). As CCl 4 have been reported for its damaging effects on the liver because on metabolism by P450, it produces free radicals (Johnston & Kroening, ).…”
Section: Resultsmentioning
confidence: 99%
“…However, for many plants, their mechanism of action against hepatotoxic agents is not well‐documented. The common prototype applied for hepatoprotective drug screening is the carbon tetrachloride (CCl 4 ) induced hepatic injury (Rodrigues et al, ). As CCl 4 have been reported for its damaging effects on the liver because on metabolism by P450, it produces free radicals (Johnston & Kroening, ).…”
Section: Resultsmentioning
confidence: 99%
“…Ridentin, sesamin, and artemetin were the most active compounds, showing an EC 50 between 3.3 and 3.8 µg/mL against P. falciparum [ 22 , 23 ]. Some metabolites isolated from this species have also been tested regarding their anti-tumoral ability with promising results [ 24 ], as well as their hepatoprotective potential [ 25 ]. The Artemisia genus belongs to the Asteraceae family and 500 species have been reported, the majority of which are found in the temperate areas of Asia, Europe, and North America.…”
Section: Discussionmentioning
confidence: 99%