Potencial antiviral da quercetina sobre o parvovírus canino

Carvalho, Otávio Valério de; Oliveira, Fabíola Singaretti; Saraiva, Giuliana Loreto; Botelho, Clarisse Vieira; Ferreira, Hanna Carolina Campos; Santos, Marcelo Rocha dos; Júnior, Abelardo Silva; Almeida, Márcia R.

doi:10.1590/s0102-09352013000200008

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…Previous studies show quercetin can bind with glycoproteins from the viral envelope and cellular receptors by modifying their chemical structure and blocking the virusbinding site. Brum et al [63] demonstrated a reduction in the virucide activities of some viruses with this substance, while Carvalho et al [64] confirmed its effects against canine parvovirus in vitro studies.…”

Section: Discussionmentioning

confidence: 99%

Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies

et al. 2023

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Objectives This scoping review aims to present flavonoid compounds' promising effects and possible mechanisms of action on potential therapeutic targets in the SARS-CoV-2 infection process. Methods A search of electronic databases such as PubMed and Scopus was carried out to evaluate the performance of substances from the flavonoid class at different stages of SARS-CoV-2 infection. ResultsThe search strategy yielded 382 articles after the exclusion of duplicates. During the screening process, 265 records were deemed as irrelevant. At the end of the full-text appraisal, 37 studies were considered eligible for data extraction and qualitative synthesis. All the studies used virtual molecular docking models to verify the affinity of compounds from the flavonoid class with crucial proteins in the replication cycle of the SARS-CoV-2 virus (Spike protein, PLpro, 3CLpro/ MPro, RdRP, and inhibition of the host's ACE II receptor). The flavonoids with more targets and lowest binding energies were: orientin, quercetin, epigallocatechin, narcissoside, silymarin, neohesperidin, delphinidin-3,5-diglucoside, and delphinidin-3-sambubioside-5-glucoside. Conclusion These studies allow us to provide a basis for in vitro and in vivo assays to assist in developing drugs for the treatment and prevention of COVID-19.

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Section: Discussionmentioning

confidence: 99%

Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies

et al. 2023

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“…No Quadro 1, pode-se visualizar os principais constituintes já detectados na espécie supracitada. (CARVALHO et al, 2013;PEREIRA, 2017;SOUZA, 2009).…”

Section: Perfil Fitoquímico Da Fava D'antaunclassified

Variáveis interferentes, composição fitoquímica e atividades biológicas da Fava D’anta: uma revisão de literatura

Silva Neto,

Lima,

Santos

et al. 2021

SciNat

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A Fava D'anta (Dimorphandra) é um gênero vegetal que pertence à família Fabaceae com grande potencial farmacológico. Assim, objetivou-se apresentar a Fava D'anta, expor sua composição fitoquímica, algumas de suas propriedades farmacológicas e as variáveis interferentes na sua composição e desenvolvimento. Foi realizado uma revisão de literatura nas bases de dados: Google Acadêmico e SciELO, por meio dos descritores: Fava D'anta, Fitoquímicos "Phytochemicals", Atividades biológicas "Biological activities" e Variáveis interferentes "Interfering variables", combinados pelo operador booleano "AND". Incluiu-se estudos nos idiomas Inglês e Português, que apresentassem pelo menos um dos descritores supracitados, sendo eles publicados entre 2009 e março de 2021. A partir da análise dos dados, constata-se que a Fava D'anta possui grande potencial farmacológico devido a presença de diversos fitoquímicos, destacando-se os flavonoides, mais especificamente a rutina, contendo atividade anti-inflamatória, antimicrobiana, cardioprotetora e antioxidante. O solo, sombreamento, estado de maturação, sazonalidade e solvente extrator podem afetar o perfil dos metabólitos secundários ali presentes. Sendo assim, estudos adicionais são importantes para um maior conhecimento sobre as diferentes formas de ação desta planta para a produção de um possível fármaco a partir da mesma. Palavras-chave: Fava D'anta. Fitoquímicos. Variáveis interferentes.

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“…These negative results differ from those reported in previous studies with these plant species. Divergences may be related to several variables, such as (1) variations in the concentrations of secondary metabolites present in the plants, related to factors that may influence compound extractions (discussed above); (2) the chemical structure of these metabolites; (3) the fact that the phytochemical mechanism of action on the interaction capacity with the virus is different for each pathogen (Carvalho et al, 2013); and (4) the possibility of synergism or antagonism between extracted compounds (Cos et al, 2006;Kumar, Pandey, 2013). The aim of this study was not to investigate the constituents or their relationships that could be responsible for the observed effects, both in the cytotoxicity assays and in the antiviral activity trials.…”

Section: N T H I S S T U D Y T W O S P E C I E S B E L O N G I N Gmentioning

confidence: 99%

Cytotoxicity and antiviral activity evaluation of Cymbopogon spp hydroethanolic extracts

Chiamenti

Silva

Schallemberger

et al. 2019

Braz. J. Pharm. Sci.

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Cymbopogon citratus and C. nardus are noteworthy among the several existing plant species displaying medicinal properties, due to the potential pharmacological activity of these species, including antiviral, antibacterial, antifungal and anti-trypanosomal activities. The objective of this study was to carry out in vitro toxicity tests of plant extracts from both species and analyze potential antiviral activity against Human mastadenovirus serotype 5 (HAdV-5). Two cell lines (A549 and VERO) were used and mitochondrial and lysosomal viability were determined by the MTT and neutral red assay, respectively, after two exposure times (24 hours and six days). The aim of these assays was to counteract the behavior of the extracts against the different cell lines and determine their non-toxic concentration range, in order to evaluate possible antiviral activity against HAdV-5. Plaque reduction and inhibition index of viral titer assays were performed using the maximum non-cytotoxic concentrations (MNCC) of each extract. The results indicate MNCC at 625 μg/mL for all extracts, except for Cymbopogon nardus obtained with 80% ethanol (CN80), which showed toxicity at concentrations higher than 312.5 μg/mL. CN80 was the only extract that displayed potential activity against HAdV-5, at a concentration of 75 μg/mL, becoming a candidate for extract fraction purification and/or the isolation of substances related to the observed antiviral activity.

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Potencial antiviral da quercetina sobre o parvovírus canino

Cited by 6 publications

References 15 publications

Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies

Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies

Variáveis interferentes, composição fitoquímica e atividades biológicas da Fava D’anta: uma revisão de literatura

Cytotoxicity and antiviral activity evaluation of Cymbopogon spp hydroethanolic extracts

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