Potency of Melatonin in Living Beings

Choi, Donchan

doi:10.12717/dr.2013.17.3.149

Cited by 20 publications

(16 citation statements)

References 227 publications

(237 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As SP presents longer period of darkness than LP, the period of elevated melatonin is relatively longer in SP, which is reflected by the length of melatonin secretion. Various modes of administration of melatonin into the animals, such as injections, implants, and infusions, have been applied whether they resulted in the testicular regression ( Reiter 1980 ; Stetson & Tay, 1983 ; Stetson et al, 1983 ; Stetson & Watson-Whitmyre, 1984 ; Stetson & Watson-Whitmyre, 1986 ; Maywood et al, 1991 ; Grosse et al, 1993 ; Choi, 2001 ; Hiebert et al, 2006 ; Choi, 2013a ; Choi, 2013b ). Some plants also contain melatonin called phytomelatonin, structurally an identical molecule ( Dubbels et al., 1995 ; Hattori et al, 1995 ; Paredes et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Daily Melatonin Gavage on Reproductive Activity in the Male Syrian Hamsters

et al. 2020

Self Cite

View full text Add to dashboard Cite

The proper administration of melatonin has well been documented to induce testicular regression in seasonal breeding animals. The subcutaneous injections of melatonin in the afternoon, not in the morning, consistently occurred testicular involution in the male Syrian (golden) hamsters whose reproductive activity is regulated by the photoperiod. But the effects of daily melatonin via gavage have not been estimated. Golden hamsters housed in long photoperiod (LP) were divided into 5 groups: the control animals housed in LP or in short photoperiod (SP) and animals treated daily with low (15 μg), middle (150 μg), and high dosages (1,500 μg) of pure melatonin by using gavage in the evening for 8 weeks. As results, LP control animals had large testes and SP controls displayed small and entirely regressed testes. The animals treated with various dosages of melatonin showed collectively degenerating effects on the weights of testes, epididymides, and seminal vesicles in the middle and high dosage groups, with the individual differences as well. The high dosages induced testicular regression in more proportion than the middle dosages did. The low dosage had large testes like the LP control animals. The small and inactive testes shown in some animals of both middle and high groups presented the complete regression as those of the animals maintained in SP. These results strongly suggest that the administrations of melatonin lead to testicular involution in the male golden hamsters when it is administered through gavage.

show abstract

Section: Introductionmentioning

confidence: 99%

The Effects of Daily Melatonin Gavage on Reproductive Activity in the Male Syrian Hamsters

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…The most common physiological effect of melatonin is coordinating circadian activity. It serves as a chronobiotic factor to maintain circadian rhythm amplitudes and reinforce oscillations of the biological clock [12,13]. Secretion of melatonin is tightly regulated by light, thus disruption usually occurs in individuals deprived of light such as travellers across time zone and night-shift workers.…”

Section: Introductionmentioning

confidence: 99%

Melatonin Prevents Oxidative Stress-Induced Mitochondrial Dysfunction and Apoptosis in High Glucose-Treated Schwann Cells via Upregulation of Bcl2, NF-κB, mTOR, Wnt Signalling Pathways

Tiong

Koh

et al. 2019

Antioxidants

View full text Add to dashboard Cite

Neuropathy is a complication that affects more than 50% of long-standing diabetic patients. One of the causes of diabetes neuropathy (DN) is the apoptosis of Schwann cells due to prolonged exposure to high glucose and build-up of oxidative stress. Melatonin is a hormone that has a known antioxidant property. In this study, we investigated the protective effect of melatonin on high glucose-induced Schwann cells’ apoptosis. Our results revealed that high glucose promoted apoptosis via mitochondrial-related oxidative stress and downregulated Bcl-2 family proteins in Schwann cells. In this signalling pathway, Bcl-2, Bcl-XL and Mcl-1 proteins were down-regulated while p-BAD and Puma proteins were up-regulated by high glucose treatment. Besides, we also proved that high glucose promoted apoptosis in Schwann cells through decreasing the p-NF-κB in the NF-κB signalling pathway. Key regulators of mTOR signalling pathway such as p-mTOR, Rictor and Raptor were also down-regulated after high glucose treatment. Additionally, high glucose treatment also decreased the Wnt signalling pathway downstream proteins (Wnt 5a/b, p-Lrp6 and Axin). Our results showed that melatonin treatment significantly inhibited high glucose-induced ROS generation, restored mitochondrial membrane potential and inhibited high glucose-induced apoptosis in Schwann cells. Furthermore, melatonin reversed the alterations of protein expression caused by high glucose treatment. Our results concluded that melatonin alleviates high glucose-induced apoptosis in Schwann cells through mitigating mitochondrial-related oxidative stress and the alterations of Bcl-2, NF-κB, mTOR and Wnt signalling pathways.

show abstract

“…Melatonin and phytomelatonin are structurally the identical molecule, but melatonin refers to animal origin and the term phytomelatonin to plant origin. The findings raised an interest in investigating the potential effects of plant phytomelatonin on the reproductive activity of small animals, among the diverse capacities reported so far, particularly through the edible plant diet (Choi, 2013b; Bonomini et al, 2018; Jiki et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Supplement Containing Melatonin on Reproductive Activity in Male Golden Hamsters

Choi

2019

Dev. Reprod.

Self Cite

View full text Add to dashboard Cite

Melatonin is a pineal hormone that is synthesized and released at night under the light and dark cycles of a day. Its effects on the reproductive activities have well been established by the administration through various routes in photoperiodic animals. It was also identified in plants and named phytomelatonin. The capacity of the phytomelatonin was investigated in this investigation whether it affects the reproductive function in male golden hamster. As expected, animals housed in long photoperiod (long photoperiod, LP>12.5 hours of lights in a day) had large testes and animals kept in short photoperiod (SP≦12.5 hours of lights in a day) showed remarkably reduced testes. The dietary supplement with melatonin itself induced the complete involution of testes. Pistachios that were reported to contain a large amount of melatonin demonstrated no effects at all in male golden hamsters. These results suggest that dietary supplement containing melatonin-rich foodstuff used in this investigation may not be enough to affect the reproductive endocrine system in male golden hamsters.

show abstract

Potency of Melatonin in Living Beings

Cited by 20 publications

References 227 publications

The Effects of Daily Melatonin Gavage on Reproductive Activity in the Male Syrian Hamsters

The Effects of Daily Melatonin Gavage on Reproductive Activity in the Male Syrian Hamsters

Melatonin Prevents Oxidative Stress-Induced Mitochondrial Dysfunction and Apoptosis in High Glucose-Treated Schwann Cells via Upregulation of Bcl2, NF-κB, mTOR, Wnt Signalling Pathways

Effects of Dietary Supplement Containing Melatonin on Reproductive Activity in Male Golden Hamsters

Contact Info

Product

Resources

About