Potent and long-lasting anticonvulsant effects of 1-naphthylacetyl spermine, an analogue of Joro spider toxin, against amygdaloid kindled seizures in rats

Takazawa, Akira; Kanai, Hirohiko; Ishida, Noriko; Kato, Nobuo; Yamauchi, Takeshi

doi:10.1016/0006-8993(95)01334-2

Cited by 33 publications

(20 citation statements)

References 14 publications

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“…Further, as might be predicted from the DNQX/feeding study and the association between feeding and ICSS, viral vector-mediated overexpression of AMPA GluR1 in NAc shell decreased lateral hypothalamic ICSS (Todtenkopf et al 2006). The second aim of this study was therefore to determine whether microinjection of the broad spectrum AMPA/kainate antagonist, DNQX, and/or the selective polyamine antagonist of Ca 2+ -permeable AMPA receptors (i.e., GluR2-lacking), 1-naphthylacetyl spermine (e.g., Takazawa et al 1996), potentiate lateral hypothalamic ICSS and do so to a greater extent in FR than AL subjects.…”

Section: Introductionmentioning

confidence: 99%

Reward-potentiating effects of D-1 dopamine receptor agonist and AMPAR GluR1 antagonist in nucleus accumbens shell and their modulation by food restriction

2008

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Rationale-Previous studies have suggested that chronic food restriction (FR) increases sensitivity of a neural substrate for drug reward. The neuroanatomical site(s) of key neuroadaptations may include nucleus accumbens (NAc) where changes in D-1 dopamine (DA) receptor-mediated cell signaling and gene expression have been documented.Objectives-The purpose of the present study was to begin bridging the behavioral and tissue studies by microinjecting drugs directly into NAc medial shell and assessing behavioral effects in free-feeding and FR subjects.Materials and methods-Rats were implanted with microinjection cannulae in NAc medial shell and a subset were implanted with a stimulating electrode in lateral hypothalamus. Rewardpotentiating effects of the D-1 DA receptor agonist, SKF-82958, AMPAR antagonist, DNXQ, and polyamine GluR1 antagonist, 1-na spermine, were assessed using the curve-shift method of selfstimulation testing. Motor-activating effects of SKF-82958 were also assessed.Results-SKF-82958 (2.0 and 5.0 µg) produced greater reward-potentiating and motor-activating effects in FR than ad libitum fed (AL) rats. DNQX (1.0 µg) and 1-na spermine (1.0 and 2.5 µg) selectively decreased the x-axis intercept of rate-frequency curves in FR subjects, reflecting increased responding for previously subthreshold stimulation.Conclusions-Results suggest that FR may facilitate reward-directed behavior via multiple neuroadaptations in NAc medial shell including upregulation of D-1 DA receptor function involved in the selection and expression of goal-directed behavior, and increased GluR1-mediated activation of cells that inhibit nonreinforced responses.

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Section: Introductionmentioning

confidence: 99%

Reward-potentiating effects of D-1 dopamine receptor agonist and AMPAR GluR1 antagonist in nucleus accumbens shell and their modulation by food restriction

2008

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“…On the other hand, kindling or epileptic activity seem to modify the properties of AMPA receptors. Amygdaloid kindling down-regulates GluR-2 (170, 171) and the kindled seizures can be blocked by 1-naphthylacetyl spermine, an analogue of Joro spider toxin (133).…”

Section: Epilepsymentioning

confidence: 99%

Synaptic and Non-synaptic AMPA Receptors Permeable to Calcium

König

Poluch

Estabel

et al. 2001

Japanese Journal of Pharmacology

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ABSTRACT-For a long time, alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) receptors permeable to calcium have been considered to be either non-existent or as "atypical". There is now ample evidence that these receptors exist in numerous regions of the nervous system and in many neuronal as well as non-neuronal cell populations. This evidence has been accumulated by several methods, including electrophysiological recording, calcium imaging and cobalt-loading. Functional AMPA receptors permeable to calcium are already expressed at very early stages of embryonic development, well before the onset of synaptogenesis. They are probably involved in the paracrine signaling necessary for construction of the nervous system before becoming involved in synaptic transmission. In immature cells, cyclothiazide strongly increases the steady-state level of responses not only to AMPA, but also to kainate. Ingestion, during pregnancy, of food or drug substances that can cross the placental barrier and act upon the embryonic receptors may constitute a risk for normal development. In the adult nervous system, synaptic as well as non-synaptic (paracrine) AMPA receptors permeable to calcium are probably widely expressed in both glial and neuronal cells. They may also participate in controlling some aspects related to adult neurogenesis, in particular the migration of newly formed neurons.

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“…10.019 0021-9614/Ó 2015 Elsevier Ltd. All rights reserved. useful as a pharmacological tool for investigating physiological and pathological roles of AMPA receptors, and to develop new agents for the treatment of neuronal cell death and epilepsy [26,27]. Studies on the DNA binding of this analogue have not been investigated yet.…”

Section: Introductionmentioning

confidence: 99%

Targeting of 1-Naphthyl acetyl spermine to DNA: A calorimetric and spectroscopic investigation

Kabir

Kumar

2016

The Journal of Chemical Thermodynamics

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Potent and long-lasting anticonvulsant effects of 1-naphthylacetyl spermine, an analogue of Joro spider toxin, against amygdaloid kindled seizures in rats

Cited by 33 publications

References 14 publications

Reward-potentiating effects of D-1 dopamine receptor agonist and AMPAR GluR1 antagonist in nucleus accumbens shell and their modulation by food restriction

Reward-potentiating effects of D-1 dopamine receptor agonist and AMPAR GluR1 antagonist in nucleus accumbens shell and their modulation by food restriction

Synaptic and Non-synaptic AMPA Receptors Permeable to Calcium

Targeting of 1-Naphthyl acetyl spermine to DNA: A calorimetric and spectroscopic investigation

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