Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil

Alves, Uesley Vieira; Silva, Eujeane Jardim e; Santos, Jussamara Brito; Santos, Luisa Oliveira; Lanna, Emílio; Pinto, Ana Claudia de Souza; Fonseca, Amanda Luisa da; Varotti, Fernando de Pilla; Batista, Ronan

doi:10.1016/j.ijpddr.2021.08.002

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…The marine sponge A. fulva was collected at Porto da Barra Beach in Salvador, Bahia, Brazil, the same locality as previously reported [ 11 ]. Once identified, the material was extracted with methanol and ethyl acetate (AcOEt), and the combined organic solution was evaporated and suspended in water for extraction with ethyl acetate.…”

Section: Resultsmentioning

confidence: 99%

Methanolic Extract and Brominated Compound from the Brazilian Marine Sponge Aplysina fulva Are Neuroprotective and Modulate Inflammatory Profile of Microglia

Nunes,

Santos,

Soares

et al. 2024

Marine Drugs

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Neurodegenerative diseases involve neuroinflammation and a loss of neurons, leading to disability and death. Hence, the research into new therapies has been focused on the modulation of the inflammatory response mainly by microglia/macrophages. The extracts and metabolites of marine sponges have been presented as anti-inflammatory. This study evaluated the toxicity of an extract and purified compound from the Brazilian marine sponge Aplysina fulva as well as its neuroprotection against inflammatory damage associated with the modulation of microglia response. PC12 neuronal cells and neonatal rat microglia were treated with the methanolic extract of A. fulva (AF-MeOH, 0.1–200 μg/mL) or with its purified dimethyl ketal of 3,5-dibromoverongiaquinol (AF-H1, 0.1–100 μM). Cytotoxicity was determined by MTT tetrazolium, Trypan blue, and propidium iodide; microglia were also treated with the conditioned medium (CM) from PC12 cells in different conditions. The microglia phenotype was determined by the expression of Iba-1 and CD68. AF-MeOH and AF-H1 were not toxic to PC12 or the microglia. Inflammatory damage with Escherichia coli lipopolysaccharide (LPS, 5 μg/mL) was not observed in the PC12 cells treated with AF-MeOH (1–10 μg/mL) or AF-H1 (1–10 μM). Microglia subjected to the CM from PC12 cells treated with LPS and AF-MeOH or AF-H1 showed the control phenotype-like (multipolar, low-CD68), highlighting the anti-neuroinflammatory and neuroprotective effect of components of this marine sponge.

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Section: Resultsmentioning

confidence: 99%

Methanolic Extract and Brominated Compound from the Brazilian Marine Sponge Aplysina fulva Are Neuroprotective and Modulate Inflammatory Profile of Microglia

Nunes,

Santos,

Soares

et al. 2024

Marine Drugs

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“…A compound with an SI value < 1 suggests the presence of toxic components and should not be used as an herbal drug (Indrayanto et al 2021). In antimalarial research, the SI value enables a more qualitative evaluation of substances as possible new therapeutic possibilities (Teng et al 2019;Alves et al 2021).…”

Section: The Antimalarial and Cytotoxicity Assays Of Compoundmentioning

confidence: 99%

Figure 1 from: Suryanto S, Tumewu L, Ilmi H, Hafid AF, Suciati S, Widyawaruyanti A (2024) Antimalarial activity of Cratoxyarborenone E, a prenylated xanthone, isolated from the leaves of Cratoxylum glaucum Korth. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e126316

Suryanto,

Tumewu,

Ilmi

et al. 2024

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Section: The Antimalarial and Cytotoxicity Assays Of Compoundmentioning

confidence: 99%

Antimalarial activity of Cratoxyarborenone E, a prenylated xanthone, isolated from the leaves of Cratoxylum glaucum Korth

Suryanto,

Tumewu,

Ilmi

et al. 2024

PHAR

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This research aims to discover active compounds from the leaf extract from Cratoxylum glaucum using the bioassay-guided isolation method. The multistage extraction of C. glaucum leaves was conducted using n-hexane, dichloromethane, and methanol. The LDH assay was employed to analyze antimalarial activity, and the Resazurin assay was used to measure cytotoxicity values. The structure of the active isolates was determined using spectroscopic techniques. The compound 1 was successfully isolated from the dichloromethane extract of C. glaucum leaves (Cg.FD) and confirmed as a prenylated xanthone namely cratoxyarborenone E. The in vitro antimalarial activity showed an IC50 value of 5.82 ± 0.04 μM, the cytotoxicity assay exhibited a CC50 value of 20.74 ± 0.04 µM, and the SI value was determined to be 3.56. Our research demonstrates that cratoxyarborenone E was first reported from Cg.FD and shows promise as a prospective candidate for new antimalarial drugs.

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Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil

Cited by 5 publications

References 18 publications

Methanolic Extract and Brominated Compound from the Brazilian Marine Sponge Aplysina fulva Are Neuroprotective and Modulate Inflammatory Profile of Microglia

Methanolic Extract and Brominated Compound from the Brazilian Marine Sponge Aplysina fulva Are Neuroprotective and Modulate Inflammatory Profile of Microglia

Figure 1 from: Suryanto S, Tumewu L, Ilmi H, Hafid AF, Suciati S, Widyawaruyanti A (2024) Antimalarial activity of Cratoxyarborenone E, a prenylated xanthone, isolated from the leaves of Cratoxylum glaucum Korth. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e126316

Antimalarial activity of Cratoxyarborenone E, a prenylated xanthone, isolated from the leaves of Cratoxylum glaucum Korth

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