Potent anti-inflammatory activity of sesquiterpene lactones from Neurolaena lobata (L.) R. Br. ex Cass., a Q’eqchi’ Maya traditional medicine

Sesquiterpenes from Neurolaena lobata and Their Antiproliferative and Anti-inflammatory Activities

“…9 It was reported recently that the 80% EtOH extract of N. lobata leaves reduces LPS-stimulated TNF-α production in THP-1 monocytes, and isolated sesquiterpene lactones were identified as active principles of the extract. 10 The cytotoxic activities of an aqueous extract and sesquiterpene lactones of N. lobata have been examined in vitro against GLC 4 human small cell lung carcinoma and COLO 320 human colorectal cancer cells. 11 Antineoplastic properties of the dichloromethane extract have also been investigated in HL-60 cells and in anaplastic large cell lymphoma cell lines of human or mouse origin.…”

The germacranolide sesquiterpene lactone neurolenin B of the medicinal plant Neurolaena lobata (L.) R.Br. ex Cass inhibits NPM/ALK-driven cell expansion and NF-κB-driven tumour intravasation

“…The sesquiterpene lactones of N. lobata may inhibit NF-κB through a similar mechanism. However, only a part of the here and formerly analysed sesquiterpene lactones of N. lobata (Kiss et al 2015) inhibited NF-κB activity in immune-relevant cells such as monocytes and endothelial cells (McKinnon et al 2014;Walshe-Roussel et al 2013) ruling out the possibility that the α-methylene-γ -lactone ring was the major cause for NF-κB inhibition and for the abrogation of survival signals in neoplasias (Gyrd-Hansen and Meier 2010). Instead, the acetyl group at C-9 and the double bonds C-4/5 and C-2/3 are held responsible for the anti-inflammatory activity of neurolenin B and lobatin A and for other sesquiterpene lactones studied (McKinnon et al 2014).…”

Pharmacological insight into the anti-inflammatory activity of sesquiterpene lactones from Neurolaena lobata (L.) R.Br. ex Cass

“…Similar results were obtained in the present study with lobatin B (Lob 6) in HUVECtert cells. Previously, lobatin B (Lob 6) also showed potent effect in LPS-stimulated THP-1 cells, with stronger anti-inflammatory activity than that of the positive control parthenolide (Walshe-Roussel et al, 2013). Hence, lobatin B (Lob 6) exhibits an anti-inflammatory effect comparable to that of the known NF-kB inhibitors BAY 11-7082 and parthenolide.…”

“…All rights reserved. 2001;Franç ois et al, 1996;Passreiter and Isman, 1997;Unger et al, 2013;Walshe-Roussel et al, 2013). In addition, organic fractions of N. lobata hydroalcoholic extracts demonstrated anti-ulcerogenic and anti-nociceptive effect in vivo (Gracioso et al, 1998(Gracioso et al, , 2000.…”