Potent anti-tumor promoting effects of Daucus carota oil extract in mice

Zeinab, R. M. Abou; Mroueh, Mohammad; Daher, CF

doi:10.1055/s-0028-1084274

Cited by 3 publications

(2 citation statements)

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“…(Prakash et al, 2004, Fan et al 2005Zielinska and Markowski 2007). Umbi akar wortel mempunyai manfaat dalam aktivitas farmakologi bagi kesehatan sebagai analgesik, anti-peradangan, antifertilitas, antitumor , hepatoprotektif dan sifat hipoglikemik (Prochezhian dan Ansari, 2000;Prakash et al, 2004;Abou et al, 2008, Bishayee et al, 1995, Neef et al, 1995, Patil et al, 2012. Wortel mempunyai komersial yang tinggi dan berpotensi sebagai sumber antioksidan yang alami.…”

Section: Pendahuluanunclassified

Validasi Model pada Pengeringan Batch Pada Wortel

Triyastuti¹,

Finarianingrum

Octaviani

2018

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Wortel mempunyai kandungan senyawa bioaktif yang bermanfaat bagi kesehatan. Wortel dikeringkan dengan metode pengeringan batch pada suhu 70 dan 80oC dengan laju pengeringan 0,42 m/s. Penurunan kadar air digunakan untuk memperkirakan perubahan moisture ratio dengan waktu pengeringan. Membandingkan hasil penelitian dan tujuh model pengeringan untuk mendapatkan model yang sesuai berdasarkan parameter statistik. Model model Newton, Henderson dan Pabis, Logarithmic, Two Term, dan pendekatan difusi pada suhu 70 oC dan 80oC merupakan model yang terbaik dengan R2 sebesar 0,9999.sehingga model ini mempunyai error yang kecil.

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Section: Pendahuluanunclassified

Validasi Model pada Pengeringan Batch Pada Wortel

Triyastuti¹,

Finarianingrum

Octaviani

2018

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“…In Indo China, carrots are used to regulate the functions of the stomach and intestines [5] . Pharmacologically, scientists have shown that the extract obtained from the Daucus carota possesses analgesic, anti-inflammatory [6] , antifertility [7] , antitumor [8] , hepatoprotective [9] and hypoglycemic properties [10] . Patil et al [11] studied the anti-inflammatory effects on experimental colitis in rats.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Antisecretory, Gastroprotective, and In-vitro Antacid Potential of Daucus carota in Experimental Rats

Chandra

Kishore

Ghosh

2015

Osong Public Health and Research Perspectives

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ObjectivesIn Indo China, carrots have been reported to regulate the functions of the stomach and intestines. The objective of the present investigation was to unravel the therapeutic potential of 50% ethanol extract from Daucus carota roots (EDC) on antisecretory, gastroprotective, and in vitro antacid capacity using experimental rats.MethodsAssessment of EDC antisecretory and in vivo antacid capacities was carried out using a pyloric ligation induced ulcer model. The gastroprotective effect was assessed with an absolute ethanol induced ulcer model. The integrity of gastric mucosa was evaluated using the estimation of glutathione and gastric mucus level and with histopathological examination of gastric mucosal cells. The in-vitro antacid capacity was evaluated using a titration method. The effect of the extract on the liver was assessed by measuring serum biochemical parameters.ResultsThe EDC significantly (p < 0.01–0.001) reduced gastric lesions in both models. Furthermore, the EDC also significantly (p < 0.05–0.001) reduced the volume of gastric content whereas the total acidity was significantly (p < 0.05–0.001) reduced with the doses of 100 mg/kg and 200 mg/kg EDC. Moreover, the mucus content and glutathione level increased significantly (p < 0.05) in the absolute alcohol-induced ulcer. The EDC also showed in-vitro antacid capacity. Histopathological studies further confirmed the potential of EDC by inhibiting congestion, edema, hemorrhage, and necrosis in gastric mucosa.ConclusionThe EDC exerted antisecretory, gastroprotective, and in vitro antacid potential. These activities could be attributed due to the presence of glycosides, phenolics, tannins, alkaloids, and flavonoids.

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