Potent Antibacterial Activity of Halogenated Compounds against Antibiotic-Resistant Bacteria

Vairappan, Charles Santhanaraju; Kawamoto, Tomotake; Miwa, Hideaki; Suzuki, Minoru

doi:10.1055/s-2004-832653

Cited by 77 publications

(54 citation statements)

References 9 publications

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“…Many of these natural products are pharmacologically active and marine algae, especially those from tropical and subtropical seas, are able to produce a wide range of compounds, many of which exhibit at least some degree of bioactivity (Fernández et al, 1998(Fernández et al, , 2005da Gama et al, 2002;Cassano et al, 2008;Lhullier et al, 2009;Machado et al, 2011;Santos et al, 2010). In fact, the marine environment represents a treasure trove of useful products awaiting discovery for the treatment of infectious and parasitic diseases (Vairappan et al, 2004;Morales et al, 2006), cancer (Mohammed et al, 2004;Stein et al, 2011), cognitive diseases, inflammatory processes, and viral infections (Sakemi et al, 1986). Despite the many structures known and their ecological and pharmacological importance, only a few biosynthetic studies have been performed on marine terpenoid compounds (Gross & König, 2006).…”

Section: Introductionmentioning

confidence: 99%

Overview of the taxonomy and of the major secondary metabolites and their biological activities related to human health of the Laurencia complex (Ceramiales, Rhodophyta) from Brazil

Fujii¹,

Cassano²,

Stein³

et al. 2011

Rev. bras. farmacogn.

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Abstract:In Brazil, the Laurencia complex is represented by twenty taxa: Laurencia s.s. with twelve species, Palisada with four species (including Chondrophycus furcatus now that the proposal of its transference to Palisada is in process), and Osmundea and Yuzurua with two species each. The majority of the Brazilian species of the Laurencia complex have been phylogenetically analyzed by 54 rbcL sequences, including five other Rhodomelacean species as outgroups. The analysis showed that the Laurencia complex is monophyletic with high posterior probability value. The complex was separated into five clades, corresponding to the genera: Chondrophycus, Laurencia, Osmundea, Palisada, and Yuzurua. A bibliographical survey of the terpenoids produced by Brazilian species showed that only six species of Laurencia and five of Palisada (including C. furcatcus) have been submitted to chemical analysis with 48 terpenoids (47 sesquiterpenes and one triterpene) isolated. No diterpenes were found. Of the total, 23 sesquiterpenes belong to the bisabolane class and eighteen to the chamigrene type, whose biochemical precursor is bisabolane, two are derived from lauranes and four are triquinols. Despite the considerable number of known terpenes and their ecological and pharmacological importance, few experimental biological studies have been performed. In this review, only bioactivities related to human health were considered.

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Section: Introductionmentioning

confidence: 99%

Overview of the taxonomy and of the major secondary metabolites and their biological activities related to human health of the Laurencia complex (Ceramiales, Rhodophyta) from Brazil

Fujii¹,

Cassano²,

Stein³

et al. 2011

Rev. bras. farmacogn.

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“…Com o objetivo de estabelecer os potenciais dos metabólitos de Laurencia como protótipos para novos fármacos antibacterianos, uma série de sesquiterpenos halogenados foi submetida a ensaios contra 22 cepas de bactérias patogênicas humanas, incluindo sete cepas resistentes a antibióticos (Vairappan, 2004). O laurinterol (46) O fato dos metabólitos 20 e 48 não terem apresentado bons resultados nesta pesquisa pode revelar o desenvolvimento de resistência bacteriana.…”

Section: Atividade Antitumoralunclassified

Atividade biológica de metabólitos secundários de algas marinhas do gênero Laurencia

Machado¹,

Kaiser²,

Costa³

et al. 2010

Rev. bras. farmacogn.

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RESUMO:As algas vermelhas do gênero Laurencia são conhecidas como uma riquíssima fonte de metabólitos secundários. As principais classes químicas já isoladas são terpenos -sesquiterpenos, diterpenos, triterpenos -e acetogeninas. Estudos apontam que estas substâncias apresentam importantes atividades biológicas, principalmente citotóxica e antibacteriana. Existem ainda alguns poucos trabalhos com informações sobre atividade antiparasitária, antiviral e antifúngica dos metabólitos de Laurencia. O forte perfil bioativo observado em alguns estudos sugere que alguns destes metabólitos podem ser futuramente utilizados como fármacos ou como protótipos de novos agentes antitumorais e antibacterianos. Muitos dos metabólitos de Laurencia ainda não foram avaliados sob o ponto de vista farmacológico, o que representa um grande potencial a ser explorado por diversos campos da farmacologia.Unitermos: macroalgas, Ceramiales, Rhodomelaceae, produtos naturais.ABSTRACT: "Biological activity of the secondary metabolite from marine algae of the genus Laurencia." The red alga of the genus Laurencia is known as an endless source of metabolites. The main substances produced are sesquiterpenes, diterpenes, triterpenes and acetogenins. Many studies reveal that these metabolites are active, especially cytotoxic and antibacterial. There are few other studies that describe the antiparasital, antifungal and antiviral actions of the metabolites produced by the alga of the genus Laurencia. The results observed in some studies suggest that these metabolites may be used in the future as drugs or lead compounds as antitumoral and/or antibacterial agents. Many metabolites have not been submitted to pharmacological studies which still represents an area to be explored.

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“…7 Other reports show that some distinct seaweeds contain antimicrobial substances against both Gram-positive and -negative bacteria. 8,9 Thus, marine algae are a promising bioresource to find new antibacterial compounds against P. acnes and to develop new natural cosmetic products to prevent acne. In this study, we screened a total of 342 species of marine algae, collected from the Japanese coastline, for activity against P. acnes, and found a novel anti-P. acnes compound from one of these algae.…”

Section: Introductionmentioning

confidence: 99%

The novel anti-Propionibacterium acnes compound, Sargafuran, found in the marine brown alga Sargassum macrocarpum

et al. 2009

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We screened extracts of 342 species of marine algae collected from Japanese coastlines for antibacterial activity against Propionibacterium acnes, and found a novel antibacterial compound, which we named Sargafuran, from the MeOH extract of the marine brown alga, Sargassum macrocarpum. Sargafuran has low cytotoxicity, and the MIC against P. acnes was 15 lg ml À1 , showing a broad antibacterial activity against Gram-positive bacteria. A time-kill study showed that Sargafuran was bactericidal and completely killed P. acnes at 4ÂMIC by lysing bacterial cells. These results suggest that Sargafuran might be useful as a lead compound to develop new types of anti-P. acnes substances and new skin care cosmetics to prevent or improve acne.

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Potent Antibacterial Activity of Halogenated Compounds against Antibiotic-Resistant Bacteria

Cited by 77 publications

References 9 publications

Overview of the taxonomy and of the major secondary metabolites and their biological activities related to human health of the Laurencia complex (Ceramiales, Rhodophyta) from Brazil

Overview of the taxonomy and of the major secondary metabolites and their biological activities related to human health of the Laurencia complex (Ceramiales, Rhodophyta) from Brazil

Atividade biológica de metabólitos secundários de algas marinhas do gênero Laurencia

The novel anti-Propionibacterium acnes compound, Sargafuran, found in the marine brown alga Sargassum macrocarpum

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