Potent Antioxidative Activity of Cacalol, a Sesquiterpene Contained in<i>Cacalia delphiniifolia</i>Sleb et Zucc

Shindo, Kazutoshi; Kimura, Mari; Iga, Mayuko

doi:10.1271/bbb.68.1393

Cited by 40 publications

(33 citation statements)

References 15 publications

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“…The generation of reactive oxygen species (ROS) and free radicals in human is suggested to contribute to the wide range of pathological disturbances such as, inflammations, cancer, diabetes and arthritis (Shindo et al, 2004;Erasto et al, 2007). The free radicals are generated from cellular and metabolic activities, and also through exogenous sources such as human exposure to ionizing radiation, injury, oxidative drugs and pollutants (Hsu et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity and HPTLC profile of Lagenaria siceraria fruits

Erasto¹,

Mbwambo²

2009

Tanzania J Hlth Res

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Abstract:The fruits of Lagenara scerara Standl. (Cucurbitaceae) are widely used for medicinal and nutritional purposes in Africa. The health promoting ability of the fruits might be related to antioxidant properties of its constituents. In this study the antioxidant effect of fresh and dried fruits of L. scerara was evaluated by comparing the 2,2-diphenyl-1,1-picrylhydrazyl (DPPH) radical scavenging and reducing capacity of ethyl acetate and n-butanol extracts of fresh and dried fruits. The comparison was further emphasized by high performance thin layer chromatography (HPTLC) analysis of the extracts so as to relate activities with their chemical profiles. Results indicated that ethyl acetate (EA) extract of the fresh fruits exhibited higher DPPH radical scavenging activity than other samples. At 0.01 mg/ml the order of activity was: EA dried fruits (50.6%) < Bt (n-butanol) fresh fruits (53.3%) < Bt (n-butanol) dried fruits (64.8%) < EA fresh fruits (68.6%) < Gallic acid (81.8%). A slight change of activity was observed at 0.1 mg/ml, where the order was; EA dried fruits (70%) < Bt dried fruits (71.8%) ≤ Bt fresh fruits (72%) < EA fresh fruits (81.6%) < Gallic acid (88.5%). In the reducing capacity assay, Bt fresh fruits extract exhibited higher reducing power than all test samples. The HPTLC chemical profiles of both fresh and dried fruit extracts showed some slight differences. The slight differences in antioxidant activities were justified by the HPTLC chemical profiles of the fruits. Therefore, taking fresh or dried fruits of L. scerara may relatively give similar antioxidant effects. Since the fruits of this plant matures in bulky, then drying, milling and packing the products under hygiene environment can ensure a constant supply of antioxidant supplement. _______________________________________________________________________________________

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Section: Introductionmentioning

confidence: 99%

Antioxidant activity and HPTLC profile of Lagenaria siceraria fruits

Erasto¹,

Mbwambo²

2009

Tanzania J Hlth Res

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“…The generation of reactive oxygen species and free radicals in humans has recently been suggested to be a contributor to a wide range of pathologic disturbances such as myocardial and cerebral ischemia, atherosclerosis, renal failure, inflammation, cancer, diabetes, and arthritis (Haraguchi et al, 1997;Shindo et al, 2004). The generation of active oxygen species is normally catalyzed by transition metals such as Fe 2þ and Cu þ and subsequently leads to lipid peroxidation, which can result in cell death (and neoplasia) (Smith, 1985).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Constituents inVernonia amygdalina. Leaves

Erasto

Grierson

Afolayan

2007

Pharmaceutical Biology

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Vernonia amygdalina Del. (Asteraceae) is a plant widely used both for nutritional and medicinal purposes throughout the tropical Africa. The health-promoting ability of this plant species might be related to the antioxidative effect of its constituents. In this study,the antioxidant activity of this plant was evaluated by comparing the reducing capacity and the DPPH radical scavenging of two previously isolated sesquiterpene lactones (vernolide and vernodalol) with the ethanol extract from which the two compounds were isolated. Results indicated that vernolide had a higher reducing power than vernodalol and the ethanol extract. At 0.25 mg=mL, vernolide had an absorbance value of 0.15 while vernolide and the ethanol extract had absorbencies of 0.042 and 0.144, respectively. Catechin (a standard antioxidant compound), however, exhibited a higher reducing power than all the three samples. In the DPPH radical scavenging, both the sesquiterpene lactones and the ethanol extract exhibited appreciable activity. At 0.25 mg=mL, the activity order was ethanol extract > vernodalol > vernolide. At all concentrations, the ethanol extract had higher radical scavenging activity than the sesquiterpene lactones, suggesting a possible synergistic effect of these and any other antioxidant constituents.

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“…18) The results are shown in Table 1. Compounds 1, 2, 3, and 4 showed superior antioxidative activity when compared to the corresponding substrates.…”

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“…22,23) Compounds 2 and 8 were rare flavonoids whose preparation by organic synthesis has rarely been reported. 12,18) We consider that our bioconversion method using recombinant E. coli would be superior to conventional biotransformation using microbial cells in respect of product foreseeability. The products produced in this study can be candidates for biologically active chemicals, including medicines, and further biological studies on these products are in progress.…”

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confidence: 99%