Potent antiproliferative and pro-apoptotic effects of a soluble protein fraction from culinary-medicinal mushroom Lentinus tigrinus on cancer cells

Mohammadnejad, Safoora; Pourianfar, Hamid R.; Drakhshan, Ahmad; Jabaleh, Isa; Rezayi, Majid

doi:10.1007/s11694-019-00222-4

Cited by 9 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lentinus is reported as a culinary-medicinal mushroom that possesses nutritious substances and biological activities (Lee et al, 2013;Mohammadnejad et al, 2019). Both Lentinus found in this study were different in colour and size with (Putra et al, 2019b;Putra, 2020a).…”

Section: Lentinus Sp1mentioning

confidence: 62%

Diversity and Potential Utilization of Some Wild Macroscopic Fungi Around Ipb University Campus Building

Putra¹

2020

JPMIPA

View full text Add to dashboard Cite

Mushroom are cosmopolitan organisms which can emerge in a variety of environment, and around the university building is no exception.The goal of this study was to collect information on macrofungi diversity around IPB Unversity Campus Building in order to be used as a reference for its potential in the future. Macrofungi collection was done by opportunistic sampling method. All mushrooms found were Basidiomycota, which dominated by order of Agaricales. A total of 13 mushrooms were identified and described in this study, namely: Armillariella sp., Marasmiellus sp., Mycena sp., Agrocybe sp., Polyporus sp., Entoloma sp., Xeromphalina sp., Paxillus sp., Lentinus sp. 1, Lentinus sp. 2, Collybia sp., Pluteus sp., and Parasola sp. Some macroscopic fungi found to be potentially used as a bioactive compound sources, medicine and also played an important role as a decomposer in the sampling site.AbstrakJamur makroskopis merupakan organisme kosmopolitan yang mampu tumbuh pada berbagai macam kondisi lingkungan, tidak terkecuali di sekitar bangunan universitas. Tujuan dari penelitian ini adalah menyediakan informasi mengenai keragaman jamur makroskopis di sekitar kampus Institut Pertanian Bogor untuk pemanfaatannya di masa mendatang. Eksplorasi jamur dilakukan dengan metode pengambilan sampel oportunistik. Semua jamur yang ditemukan merupakan filum Basidiomycota dan didominasi oleh ordo Agaricales. Sebanyak 13 jenis jamur makro berhasil diidentifikasi dan dideskripsikan pada penelitian ini, yaitu: Armillariella sp., Marasmiellus sp., Mycena sp., Agrocybe sp., Polyporus sp., Entoloma sp., Xeromphalina sp., Paxillus sp., Lentinus sp. 1, Lentinus sp. 2, Collybia sp., Pluteus sp., dan Parasola sp. Beberapa Jamur diketahui berpotensi sebagai sumber bahan bioaktif, obat-obatan, dan dekomposer penting pada ekosistem.Kata Kunci: Gedung kampus, Jamur, Ragam, Potensi, IPB

show abstract

Section: Lentinus Sp1mentioning

confidence: 62%

Diversity and Potential Utilization of Some Wild Macroscopic Fungi Around Ipb University Campus Building

Putra¹

2020

JPMIPA

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

“…Medicinal and environmental uses: This mushroom has antimicrobial and antioxidant [ 179 ], hypoglycemic and antidiabetic [ 176 ], anti-inflammatory [ 178 ], anticancer [ 181 , 182 ], and immunomodulatory properties [ 180 ]. In addition, Mohammadnejad et al [ 181 ] reported the anticancer potentiality of a soluble protein fraction of L. tigrinus that showed greater antiproliferative and cytotoxic activities against PC3 cells; this suggests that the soluble protein fraction of this mushroom may be considered a potent anticancer compound. Recently, Pourianfar et al [ 182 ] found that wild Iranian L. tigrinus strain may be regarded as a source of macro- and micronutrients with specific anticancer potential against MCF-7 cells; however, it poses little risk to humans when consumed in small amounts.…”

Section: Resultsmentioning

confidence: 99%

Macrofungi as Medicinal Resources in Uzbekistan: Biodiversity, Ethnomycology, and Ethnomedicinal Practices

Gafforov,

Rašeta,

Rapior

et al. 2023

JoF

View full text Add to dashboard Cite

Interest in edible and medicinal macrofungi is millennial in terms of their uses in health and food products in Central Asia, while interest in inedible and medicinal macrofungi has grown in popularity in recent years. Edible and inedible medicinal basidiomycetes were collected during field surveys from different regions of Uzbekistan. The morphological characters and similarity assessment of rDNA-Internal Transcribed Spacer sequence data were used to measure diversity and habitat associations. A number of 17 species of medicinal macrofungi of ethnomycological and medicinal interest was found associated with 23 species of trees and shrubs belonging to 11 families and 14 genera. Polyporaceae and Hymenochaetaceae were represented by the highest number of species followed by Ganodermataceae, Fomitopsidaceae, Auriculariaceae, Cerrenaceae, Grifolaceae, Phanerochaetaceae, Laetiporaceae, Schizophyllaceae, and Stereaceae. The highest number of medicinal basidiomycete species was reported in the following host genera: Acer, Betula, Celtis, Crataegus, Juglans, Juniperus, Lonicera, Malus, Morus, Platanus, Populus, Prunus, Quercus, and Salix. An updated list of edible and inedible medicinal mushrooms identified in Uzbekistan, their morphological characteristics, and phylogenetic placement are given for the first time. Information is provided on their uses in traditional and modern medicine. Their bioactive compounds and extracts can be applied as medicines, as well as food and cosmetic ingredients.

show abstract

“…In that paper, it was proposed that L. tigrinus could serve as a natural antioxidant and antimicrobial source. On the other hand, since L. tigrinus is an edible mushroom ( Mohammadnejad et al, 2019 ), the restriction of over-consumption of this white-rot fungus could be necessary because of its high level of antioxidants. Moreover, the fungal extracts should be analyzed to determine the responsible bioactive secondary metabolites for its antimicrobial and antioxidant activities.…”

Section: Biologically Active Secondary Metabolites Produced By White-...mentioning

confidence: 99%

Biologically active secondary metabolites from white-rot fungi

Pinar,

Rodríguez-Couto

2024

Front. Chem.

View full text Add to dashboard Cite

In recent years, there has been a considerable rise in the production of novel metabolites derived from fungi compared to the ones originating from bacteria. These organic substances are utilized in various sectors such as farming, healthcare, and pharmaceutical. Since all dividing living cells contain primary metabolites, secondary metabolites are synthesized by utilizing intermediate compounds or by-products generated from the primary metabolic pathways. Secondary metabolites are not critical for the growth and development of an organism; however, they exhibit a variety of distinct biological characteristics. White-rot fungi are the only microorganisms able to decompose all wood components. Hence, they play an important role in both the carbon and nitrogen cycles by decomposing non-living organic substrates. They are ubiquitous in nature, particularly in hardwood (e.g., birch and aspen) forests. White-rot fungi, besides ligninolytic enzymes, produce different bioactive substances during their secondary metabolism including some compounds with antimicrobial and anticancer properties. Such properties could be of potential interest for the pharmaceutical industries. Considering the importance of the untapped biologically active secondary metabolites from white-rot fungi, the present paper reviews the secondary metabolites produced by white-rot fungi with different interesting bioactivities.

show abstract

Potent antiproliferative and pro-apoptotic effects of a soluble protein fraction from culinary-medicinal mushroom Lentinus tigrinus on cancer cells

Cited by 9 publications

References 36 publications

Diversity and Potential Utilization of Some Wild Macroscopic Fungi Around Ipb University Campus Building

Diversity and Potential Utilization of Some Wild Macroscopic Fungi Around Ipb University Campus Building

Macrofungi as Medicinal Resources in Uzbekistan: Biodiversity, Ethnomycology, and Ethnomedicinal Practices

Biologically active secondary metabolites from white-rot fungi

Contact Info

Product

Resources

About