Potent Hypocholesterolemic Activity of the YeastKluyveromyces marxianusYIT 8292 in Rats Fed a High Cholesterol Diet

Cytokine Responses of Intestinal Epithelial-Like Caco-2 Cells to Non-Pathogenic and Opportunistic Pathogenic Yeasts in the Presence of Butyric Acid

“…For example, the ingestion of S. cerevisiae has been shown to improve the feed intake and milk production of calves, 22,23) S. boulardii has been used for the treatment of human diarrhea, 24) and the ingestion of K. marxianus has been reported to decrease total cholesterol in the plasma and liver. 25,26) Our findings suggest that the ingestion of certain kinds of yeast could induce mucosal immune responses, including IL-8 production, with beneficial effects for the host, thus allowing the immune system to react against foreign substances without harmful side effects in normal healthy subjects. 17) We observed no distinct differences in the effects of non-pathogenic and opportunistic pathogenic yeasts on IL-8 induction.…”

Effects of spent brewer’s yeast and biological β-glucans on selected parameters of lipid metabolism in blood and liver in rats

“…Yoshida et al (2004) showed hypocholesterolaemic activity of spent brewer's yeast in male Wistar rats at the concentration of 10% in the diet. In contrast, brewer's yeast and baker's yeast, which have been predominantly used for food, did not exhibit hypocholesterolaemic activity even when administered at concentration of 10%.…”

“…Studies in this area have been conducted with the use of the bakery yeast, namely S.cerevisiae, Candida utilis i Kluyveromyces marxianus and pertained their use as source of B group vitamins, dietary fibre and protein (Yoshida et al, 2004).…”

Effect ofKluyveromyces marxianusYIT 8292 Crude Cell Wall Fraction on Serum Lipids in Normocholesterolemic and Mildly Hypercholesterolemic Subjects

“…5) Belem and Lee have outlined the following advantages of K. marxianus as a food material: 5) (i) it shows good growth yield, which is important for cost efficiency in the food industry; (ii) it is accepted as a safe microorganism; (iii) it is a lactosefermenting yeast that can grow on whey waste; (iv) it is the only yeast permitted to be grown on whey in the USA. We reported in a previous study that of the 81 yeast strains used in the food industry, K. marxianus YIT 8292 whole cells exhibited the most potent hypocholesterolemic activity in rats fed a high-cholesterol diet, 6) and we have found that cell wall polysaccharides were the major active components of K. marxianus YIT 8292. 7) In rats, feeding cell wall polysaccharide-enriched fractions (crude cell wall and cell wall fractions) resulted in increased fecal sterol excretion and cecal concentration of short-chain fatty acids (SCFA).…”

“…We found in a previous study that the hypocholesterolemic activity of yeasts varied markedly between species and strains, and that strains of K. marxianus, especially K. marxianus YIT 8292, exhibited more potent hypocholesterolemic activity than other yeasts containing baker's yeast or brewer's yeast. 6) Nguyen et al reported that the composition of cell wall polysaccharides varied with species and strain. 19) The differences in hypocholesterolemic activity between those yeasts might reflect compositional differences in cell wall polysaccharides.…”