Potent in vitro antileishmanial activity of a nanoformulation of cisplatin with carbon nanotubes against Leishmania major

Akhtari, Javad; Faridnia, Roghiyeh; Kalani, Hamed; Bastani, Reza; Fakhar, Mahdi; Rezvan, Hossein; Kazemi‐Beydokhti, Amin

doi:10.1016/j.jgar.2018.09.004

Cited by 23 publications

(10 citation statements)

References 28 publications

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“…The value of size was between 100 and 1000 nm in the longitudinal direction, and the diameter was <10 nm and <30 nm for CP-SWCNT and CP-MWCNT, respectively (Figure 18). The IC 50 obtained with CP-SWCNT was 0.39 μM and for CP-MWCNT was 0.24 μM against promastigote, while against amastigote the IC 50 was 0.17 and 0.11 μM, respectively [25]. Peripheral nerve injury (PNI) often results in a loss of sensory, motor, and autonomic functions in the affected region.…”

Section: Miscellaneousmentioning

confidence: 99%

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Biomedical Applications of Nanomaterials: Nanotubes and Metal-Organic Frameworks (MOFs)

Martell-Mendoza¹,

Pérez-González²,

Beltrán³

et al. 2020

Biochemical Toxicology - Heavy Metals and Nanomaterials

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Nanomedicine plays an important role in the diagnosis, treatment, monitoring and control of biological systems in the area of nanotechnology and has been referred by the National Institute of Health (NIH) as an emergent way of medicine. Nanoparticles are new delivery vehicles with the ability to release drugs to a specific cell type or tissue, which may also improve the pharmacological activity of those drugs by controlling their release, as well as prolonging their short half-lives in blood. The aim of this review is to gather several options of MOFs and nanotubes synthesised with different nanoparticles and processes, some including compound loading and release studies, with particular focus on 13 anti-cancer compounds e.g. doxorubicin, curcumin, methotrexate, etc.; 3 anti-inflammatory compounds, namely ibuprofen, salicylic acid and chlorogenic acid; and with 5 miscellaneous bioactive compounds, including rifampicin, griseofulvin, enoxacin, etc. Finally, other biomedical applications for these composites are shown, like being enzyme immobilisation agents, for water treatment e.g. in swimming pools, and other becoming support to carry & secure integrity of drugs.

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Section: Miscellaneousmentioning

confidence: 99%

“…TEM images of (a) CP-SWCNT and (b) CP-MWCNT[25].Biomedical Applications of Nanomaterials: Nanotubes and Metal-Organic Frameworks (MOFs) DOI: http://dx.doi.org/10.5772/intechopen.89626 …”

mentioning

confidence: 99%

Biomedical Applications of Nanomaterials: Nanotubes and Metal-Organic Frameworks (MOFs)

Martell-Mendoza¹,

Pérez-González²,

Beltrán³

et al. 2020

Biochemical Toxicology - Heavy Metals and Nanomaterials

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“…9,10 Cisplatin was active against murine visceral leishmaniasis alone or in association. 11,12 The similarity between metabolic pathway of kinetoplastid parasites and tumor cells 13 and the fact that many antiprotozoal drugs bind to DNA, has led to the use of transition metal complexes as metallointercalators in the context of leishmaniasis. In this field, iridium, ruthenium, gold, copper, platinum and rhodium complexes have shown excellent antileishmanial activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Antileishmanial Activity of Neutral Gold(I) Complexes with N-heterocyclic Carbene Ligands Bearing Sulfur-Containing Side Arms

et al. 2021

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With an estimated annual incidence of one million cases, leishmaniasis is one of the top five vector-borne diseases. Currently available medical treatments involve side effects, including toxicity, non-specific targeting, and resistance development. Thus, new antileishmanial chemical entities are of the utmost interest to fight against this disease. We have shown in previous studies that gold(I) complexes bearing N-heterocyclic carbene (NHC) ligands with nitrogen or sulfur containing side arms have interesting biological activities in the field of cancer, malaria and leishmaniasis. The present study evaluates the in vitro antileishmania effects on L.infantum axenic amastigotes and their cytotoxicity for the human Thp1 cell line of a new family of 6 new imidazolium salts and their corresponding neutral (NHC)Au(I)Cl complexes. All new compounds have been characterized by classical analytical methods and five gold complexes have been evidenced by X-ray structure determination. We showed that one proligand has moderate activity (IC 50 = 8.24 µM) while 4 of 6 gold complexes have IC 50 values in the µM range (0.15-1.3 µM) including 3 with SI's between 46 and 108. These results suggest remarkable leishmanicidal activity in vitro for 3 new neutral (NHC)Au(I)Cl complexes making them candidate for further in vivo studies which are under investigation.

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“…More than one million new cases of CL are reported annually in worldwide but the real figures are 6 to 10-folds. About 90% of all cases of CL occur in Afghanistan, Algeria, Brazil, Iran, Peru, Saudi Arabia, and Syria (3)(4)(5)(6). ZCL and ACL are the most common forms of cutaneous leishmaniasis in Iran.…”

Section: Introductionmentioning

confidence: 99%

Eco-Epidemiology of Cutaneous Leishmaniasis in Golestan Province, Northeastern Iran: A Systematic Review

et al. 2020

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Background and objective: zoonotic cutaneous leishmaniasis (ZCL) is one of the most important health problems in Golestan Province, northeastern Iran. Several studies have investigated various aspects of the disease in this province. Herein, we provide a detailed review of the results of all studies related to leishmaniasis to give a reliable insight into the state of the disease in this province. Methods: The search for articles was performed in PubMed, Scopus, and Web of Science without language restriction until the beginning of 2019. Articles in Persian were retrieved from the Magiran, Scientific Information Database, and IranMedex. Overall, 41 articles were subjected to content analysis under the different themes. Results: Counties of Gonbad-e-Kavus and Maraveh Tappeh are endemic areas of ZCL with an incidence rate 99.4-379.1 in 100000 population and has mesoendemic situation in these counties. Leishmania major is the dominant (99.1%) agent of leishmaniasis. Among 18 sandflies species detected in the province, Phlebotomus papatasi was the main vector of the disease with a mean infection rate of 9.2%. Peak of sandflies activity was recorded in the mid-July and mid-September. Rhombomys opimus and Meriones libycus were the main reservoirs of this disease with a mean infection rate of 25.3 and 31.8%. The density of sandflies and wild rodents were highest in the endemic areas for ZCL. Conclusion: In Golestan Province, ZCL has been in a hypoendemic situation and in some areas in a mesoendemic situation and has increased significantly in recent years, so it is recommended to investigate the reasons for this increase.

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Potent in vitro antileishmanial activity of a nanoformulation of cisplatin with carbon nanotubes against Leishmania major

Cited by 23 publications

References 28 publications

Biomedical Applications of Nanomaterials: Nanotubes and Metal-Organic Frameworks (MOFs)

Biomedical Applications of Nanomaterials: Nanotubes and Metal-Organic Frameworks (MOFs)

Synthesis, Characterization, and Antileishmanial Activity of Neutral Gold(I) Complexes with N-heterocyclic Carbene Ligands Bearing Sulfur-Containing Side Arms

Eco-Epidemiology of Cutaneous Leishmaniasis in Golestan Province, Northeastern Iran: A Systematic Review

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