POTENT INHIBITION OF Peperomia pellucida EXTRACTS TOWARDS RANKL-INDUCED OSTEOCLAST FORMATION THROUGH M1 MACROPHAGE POLARIZATION

Kartika, I Gusti Agung Ayu; Riani, C.; Insanu, Muhamad; Paiboonsukwong, Kittiphong; Charoenphandhu, Narattaphol; Tubsuwan, Alisa; Adnyana, I Ketut

doi:10.31788/rjc.2021.1426073

Cited by 4 publications

(3 citation statements)

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“…Sirih bumi (Peperomia pellucida (L.) Kunth) was the promising plant that was classified as a weed. This plant is rich in pharmacological benefits (3)(4)(5)(6)(7)(8) .…”

Section: Introductionmentioning

confidence: 99%

Stabilisation Potential of Cell Membrane from Different Polarity Extract of Sirih Bumi (Peperomia pellucida [L.] Kunth) as Anti-inflammatory Agent

Ayu Kartika,

Suryani,

Setya Palupi

et al. 2023

Indonesian. J. Pharm. Sci.

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Sirih bumi (Peperomia pellucida [L.] Kunth.) is a medicinal herb. Anti-inflammatory activities are reported. These plant extracts have been shown to reduce inflammation in many studies, but it is unknown which extract works best. The objectives if this study were determine the extract that has the best anti-inflammatory activity from sirih bumi. The activity was assessed from the impact of stabilising red blood cell membranes in vitro. The research was then continued with a literature study on the chemical compounds containing the best extracts. To determine the prediction of the compound responsible for its activity and potency, several in silico tests were carried out, such as PASS online, Pre-ADMET online, and Protox II. The test results showed that the ethyl acetate extract at 200 g/mL concentration showed similar activity to aspirin at the same concentration. The activity of this extract increased with increasing concentration of the extract. Six compounds were reported to be isolated from this type of extract. Dillapiol and its derivative 6-allyl-5-methoxy-1,3-benzodioxol-4-ol are predicted to be compounds that have anti-inflammatory effects by inhibiting the membrane permeability mechanism of ethyl acetate extract. Ethyl acetate extract showed the best anti-inflammatory activity among the other type of extract from sirih bumi. Ethyl acetate extract is a type of extract with the best anti-inflammatory activity from sirih bumi.

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“…Sirih bumi (Peperomia pellucida (L.) Kunth) was the promising plant that was classified as a weed. This plant is rich in pharmacological benefits (3)(4)(5)(6)(7)(8) .…”

Section: Introductionmentioning

confidence: 99%

Stabilisation Potential of Cell Membrane from Different Polarity Extract of Sirih Bumi (Peperomia pellucida [L.] Kunth) as Anti-inflammatory Agent

Ayu Kartika,

Suryani,

Setya Palupi

et al. 2023

Indonesian. J. Pharm. Sci.

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show abstract

“…1 Its effect on bone is promoted by its oestrogenic effect, its ability to induce calcium homeostasis, anabolic effects on osteoblasts, inhibition of osteoclastogenesis, antioxidant effects, and bone-related nutritional content. 2 , 3 , 4 , 5 , 6 , 7 , 8 Additionally, the analgesic, anti-inflammatory and antibacterial effects of this plant may be beneficial in wound treatment, including healing tooth sockets at post-extraction. The anti-inflammatory, antihemorrhagic, and wound healing properties of this plant have been mentioned in Ayurveda records.…”

Section: Introductionmentioning

confidence: 99%

Peperomia pellucida extracts stimulates bone healing in alveolar socket following tooth extraction

Kartika

Riani

Insanu

et al. 2022

Journal of Traditional and Complementary Medicine

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“…Sirih bumi has not been widely cultivated so it is only considered as a DOI : https://doi.org/10.24843/JPSA.2022.v04.i01.p06 weed. This plant is known to have many pharmacological activities, including antiinflammatory [3][4][5][6][7][8][9] . This article summarizes and discusses the latest research developments related to sirih bumi as an anti-inflammatory agent.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Activities of Peperomia Pellucida [L.] Kunth.: A Review

Kartika

Sinarsih²,

Nayaka³

2022

JPSA

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Background: Inflammation is a natural body response, but when it reaches the systemic chronic inflammation stage, it can cause more dangerous complications. Many natural ingredients have been developed as anti-inflammatory agents. One of them is sirih bumi (Peperomia pellucida [L.] Kunth). Objective: This study aims to summarize and examine the research results related to the anti-inflammatory activity of the sirih bumi. Methods: Research articles were collected from various online databases such as Google Scholar, Google, Medline, Pubmed, and Science Direct. Inclusion and exclusion criteria were applied to obtain original research articles relevant to the desired topic, published in the last ten years, the full text was accessible, and the research methods and results were well explained and valid. Results: In total, only six articles are eligible to be discussed. The research was conducted in Indonesia, Nigeria, and Malaysia. In vitro and in vivo methods with various models and parameters were used to test the anti-inflammatory activity. All parts of the plant are proven to have anti-inflammatory effects that can be presented in extracts or herbal teas. The activity of sirih bumi is determined by the dose or concentration of administration, processing process, and harvest time. The combination with other samples must be reconsidered to maintain the desired anti-inflammatory effect. Conclusion: Anti-inflammatory activity of sirih bumi has been proven through various studies. The development of the sirih bumi product is expected to help handle inflammation and other diseases related to inflammation. Keywords : peperomia pellucida, inflammation, extract, tea

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POTENT INHIBITION OF Peperomia pellucida EXTRACTS TOWARDS RANKL-INDUCED OSTEOCLAST FORMATION THROUGH M1 MACROPHAGE POLARIZATION

Cited by 4 publications

References 0 publications

Stabilisation Potential of Cell Membrane from Different Polarity Extract of Sirih Bumi (Peperomia pellucida [L.] Kunth) as Anti-inflammatory Agent

Stabilisation Potential of Cell Membrane from Different Polarity Extract of Sirih Bumi (Peperomia pellucida [L.] Kunth) as Anti-inflammatory Agent

Peperomia pellucida extracts stimulates bone healing in alveolar socket following tooth extraction

Anti-Inflammatory Activities of Peperomia Pellucida [L.] Kunth.: A Review

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