2004
DOI: 10.1016/j.vaccine.2003.10.020
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Potent, long lasting systemic antibody levels and mixed Th1/Th2 immune response after nasal immunization with malaria antigen loaded PLGA microparticles

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Cited by 87 publications
(50 citation statements)
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“…Two PLGA copolymers (Resomer ® RG503 and RG756) with different lactide/glycolide ratio, 50:50 and 75:25 (6-12 weeks and over than 18 weeks degradation rate, respectively), were selected to carry out the studies. As expected, based on previously reported works 2004b), no influence of the polymer type used was observed either relative to the microsphere physical characteristics, mean distribution size, and zeta potential, or regarding peptide entrapment, total antigen load, and surface adsorbed peptide. The only difference found between both PLGA MP formulations was the antigen release profile, as was shown by the peptide in vitro release study.…”
Section: Discussionsupporting
confidence: 88%
“…Two PLGA copolymers (Resomer ® RG503 and RG756) with different lactide/glycolide ratio, 50:50 and 75:25 (6-12 weeks and over than 18 weeks degradation rate, respectively), were selected to carry out the studies. As expected, based on previously reported works 2004b), no influence of the polymer type used was observed either relative to the microsphere physical characteristics, mean distribution size, and zeta potential, or regarding peptide entrapment, total antigen load, and surface adsorbed peptide. The only difference found between both PLGA MP formulations was the antigen release profile, as was shown by the peptide in vitro release study.…”
Section: Discussionsupporting
confidence: 88%
“…However, SPf66 loaded NPs showed a poor immunogenicity only superior to the free peptide group. 74 Wendorf et al revealed that PLGA NPs and MPs, with 110 nm and 800-900 nm in diameter, respectively, are similar in eliciting immune response according to IgG titers in mice. 16 The results of a study conducted by Thomas et al confirmed that HBsAg-loaded PLGA MSs in »5 mm diameter could elicit a more robust immune response when compared to those with a 12 mm diameter.…”
Section: Environmental Related Factorsmentioning
confidence: 99%
“…However, previous studies with malaria parasites (1,5,15,23,24,27,30) and Japanese encephalitis virus (unpublished data), which are prototypical mosquito-borne infectious protozoa and virus, respectively, indicated that mucosal vaccines could be effective alternative immunization methods.…”
mentioning
confidence: 99%