Potent Opioid Analgesia Without Respiratory Depression

An experimental study comparing the respiratory effects of tapentadol and oxycodone in healthy volunteers

“…3 Given these facts, there is an ongoing search for new potent opioids with less abuse potential and less respiratory depression than current agents. 4 Tapentadol is a relatively new potent opioid for treatment of moderate to severe nociceptive, neuropathic and cancer pain. [5][6][7] In contrast to the classical MOR agonists, tapentadol has a dual mode of action, i.e.…”