Potent reduction of basal acid output produced by meperidine

Abstract

Meperidine is a potent narcotic related chemically and pharmacologically to morphine and atropine. To examine its gastric antisecretory activity a study designed to test the effect of meperidine on basal acid secretion was carried out: 100 mg of meperidine given intramuscularly reduced basal acid output (BAO) by 66.3% at 1 hr (P less than 0.001), 64.9% at 2 hr (P less than 0.001), and 44.9% at 3 hr (P = 0.005). This degree of reduction of BAO by this dose of meperidine did not differ from that produced by 30 mg of propantheline intramuscularly. These results demonstrate that meperidine in standard classical doses is a potent inhibitor of BAO in man.

Modulation of Acid Secretion from Enriched Guinea Pig Parietal Cells by Opioid Receptors

“…Inhibitory influences of opioid mechanisms on acid secretion in vivo have been observed in the dog [11], the rat [9, 18, 23. 27], and man [2,17], In contrast, stimu latory effects occurred in the dog [10; these workers also reported inhibition] and man [6,19]. Finally, Gascoigne et al [8] found no influence of opioids on gastric acid secretion in the cat in vivo, and Canfield and Spencer [3] observed no effect in the isolated stomach of rats.…”

Validation of a New Endoscopic Technique to Assess Acid Output in Zollinger–Ellison Syndrome

“…To analyze the relationship between EGA and GA further, we investigated each specific 15minute interval collection of VO, AC, and AO measured during GA and compared these with the 15 minute results by EGA (all measurement expressed in hourly values). Greatest agreement in AO measured was seen over the third interval (minutes, 30-45) of GA, whereas the poorest agreement was seen over the second interval (minutes, [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. Overall, poor agreement is reported between the VO recorded by EGA and by GA.…”

“…In rats, anesthetic agents, including chloralose, pentobarbitone, and urethane, have mixed effects on gastric acid secretion, 21,22 whereas a combination of fluanisone, fentanyl, and midazolam inhibited acid secretion by reducing enterochromaffinlike cell histamine release. 23 In human beings, both benzodiazepines 24 and meperidine 25 have been found to inhibit acid secretion, although this inhibition does not appear to occur immediately on drug administration. Meeroff et al 25 reported data on AO inhibition by meperidine beginning at 1 hour when given intramuscularly.…”

“…23 In human beings, both benzodiazepines 24 and meperidine 25 have been found to inhibit acid secretion, although this inhibition does not appear to occur immediately on drug administration. Meeroff et al 25 reported data on AO inhibition by meperidine beginning at 1 hour when given intramuscularly. In our procedure, time from the onset of sedative delivery, which also was given perioperatively, to the end of examination generally was rapid, occurring within minutes, likely explaining why AO values did not appear to be affected in the endoscopic procedure.…”

Stereospecific Inhibition by Naloxone of Histamine-Stimulated Acid Secretion in Isolated Guinea Pig Parietal Cells

“…It is still a matter of debate whether opioids have an effect on gastric acid secre tion and if so, whether they stimulate or inhibit, and whether the effect is elicited in the gastric mucosa or centrally [3,4,6,8,9,11,12,14,17,21,23], In a previous paper [10], we have demonstrated for the first time that the opioid peptide D-ala2-Z)-leu5-enkephalin (DADLE) [25] enhanced acid secre tion stimulated by histamine in isolated and enriched guinea pig parietal cells. The effect was blocked by the competitive opioid antag onist naloxone, suggesting a specific effect on opioid receptors.…”