Potent suppression of natural killer cell response mediated by the ovarian tumor marker CA125

Patankar, Manish S.; Jing, Yu; Morrison, Jamie C.; Belisle, Jennifer A.; Lattanzio, Frank A.; Deng, Yuping; Wong, Nyet Kui; Morris, Howard R.; Dell, Anne; Clark, Gary F.

doi:10.1016/j.ygyno.2005.07.030

Cited by 130 publications

(128 citation statements)

References 38 publications

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“…MUC-16 (CA125), known to inhibit the cytotoxicity of NK cells, was recently shown to down-modulate the expression of CD16 on NK cells from ovarian carcinoma patients, although the role in regulating DNAM-1 expression was not investigated (28,52). Furthermore, several reports have noted that cytokines can modulate the expression of natural cytotoxicity receptors and NKG2D (38,53,54).…”

Section: Tumor-associated Nk Cells Fail To Target Autologous Tumor Cementioning

confidence: 99%

Primary Human Tumor Cells Expressing CD155 Impair Tumor Targeting by Down-Regulating DNAM-1 on NK Cells

Carlsten

Norell

Bryceson

et al. 2009

The Journal of Immunology

237

217

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Section: Tumor-associated Nk Cells Fail To Target Autologous Tumor Cementioning

confidence: 99%

Primary Human Tumor Cells Expressing CD155 Impair Tumor Targeting by Down-Regulating DNAM-1 on NK Cells

Carlsten

Norell

Bryceson

et al. 2009

The Journal of Immunology

237

217

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show abstract

“…Moreover, it is possible that CD56 dim NK cells acquire CD56 bright features in response to factors produced within the tumor microenvironment. Accordingly, it was shown that the MUC16 glycoprotein that is present in ovarian tumors downregulated CD16 expression, which represents a hallmark of the CD56 dim NK cell subset [101]. Furthermore, CD56 bright NK cells display improved survival under conditions of oxidative stress, often present within tumor tissue [102].…”

Section: Nk Cell Recruitment To the Tumor Sitementioning

confidence: 99%

Shaping of NK Cell Responses by the Tumor Microenvironment

Stojanović

Correia

Cerwenka

2012

Cancer Microenvironment

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Natural killer (NK) cells belong to the innate immune system and are potent cytolytic and cytokineproducing effector cells in response to tumor targets. NK cell based anti-tumor immunotherapy was so far mainly successful in patients with different types of leukemia. For instance, acute myeloid leukemia (AML) patients displayed a prolonged survival if transplanted with haploidentical stem cells giving rise to NK cells with a mismatch in inhibitory killer immunoglobulin receptors (KIRs) and recipients' HLA class I. Although promising results have been achieved with hematological tumors, solid tumors are in most cases poorly controlled by NK cells. Therapeutic protocols that aimed at improving NK cell responses in patients with solid malignancies succeeded in increasing NK cell numbers and functional responses of NK cells isolated from the patients' peripheral blood. However, in the majority of cases tumor progression and overall survival of patients were not significantly improved. There is increasing evidence that tumor-associated NK cells become gradually impaired during tumor progression compared to NK cells from peripheral blood and healthy tissues. Future protocols of NK cell based immunotherapy should integrate three important aspects to improve NK cell anti-tumor activity: facilitating NK cell migration to the tumor site, enhancing their infiltration into the tumor tissue and ensuring subsequent efficient activation in the tumor. This review summarizes the current knowledge of tumor-infiltrating NK cells and the influence of the tumor microenvironment on their phenotype and function.

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“…Patankar et al, reported that natural killer (NK) cells incubated with soluble MUC16 exhibited a 50-70% decrease in the lysis of tumor cells (Patankar et al, 2005). MUC16-expressing EOC cells are also protected from lysis by primary NK cells (Gubbels et al, 2010).…”

Section: Muc16 Roles In the Initiation And Progression Of Ovarian Cancermentioning

confidence: 99%

“…Both soluble and membrane-bound MUC16 thus appear to be potent inhibitors of NK cells response in vitro. MUC16 downregulates CD16 expression in NK cells found in peritoneal fluids of patients with EOC (Patankar et al, 2005;Belisle et al, 2007). The secreted MUC16 binds to NK cells, B cells and monocytes via Siglec-9, a receptor found on immune cells that inhibits the NK cell response .…”

Section: Muc16 Roles In the Initiation And Progression Of Ovarian Cancermentioning

confidence: 99%

The Role of MUC16 Mucin (CA125) in the Pathogenesis of Ovarian Cancer

Rancourt¹,

Matte²,

Lane³

et al. 2012

Ovarian Cancer - Basic Science Perspective

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Potent suppression of natural killer cell response mediated by the ovarian tumor marker CA125

Cited by 130 publications

References 38 publications

Primary Human Tumor Cells Expressing CD155 Impair Tumor Targeting by Down-Regulating DNAM-1 on NK Cells

Primary Human Tumor Cells Expressing CD155 Impair Tumor Targeting by Down-Regulating DNAM-1 on NK Cells

Shaping of NK Cell Responses by the Tumor Microenvironment

The Role of MUC16 Mucin (CA125) in the Pathogenesis of Ovarian Cancer

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