Potential adenovirus-mediated gene therapy of glioma cancer

Abstract

Malignant gliomas are typically characterized by rapid cell proliferation and a marked propensity to invade and damage surrounding tissues. They are the main brain tumors notoriously resistant to currently available therapies, since they fail to undergo apoptosis upon anticancer treatments. With recent advances in neuroscience and improved understanding of the molecular mechanisms of invasive migration, gene therapy provides a new strategy for treating glioma cancer. Brain tumor gene therapy using viral vectors and stem cells has shown promise in animal model and human patient studies. Here, we review recent studies on engineering adenoviral vectors that can be used as therapy for brain tumors. The new findings presented in this study are essential for the further exploration of this cancer and they represent an approach for developing a newer and more effective therapeutic approach in the clinical treatment of human glioma cancer.

Histological characteristics and markers of proliferation and differentiation in rat brain with experimental glioma

“…This study used animals in which tumor had been developing for 21-25 days, unlike other authors who used this model, however with tumor development lasting for 10-11 days 16 , 14 days 17 , or 11-21 days 18 following the cerebral implantation of C6 cells.…”

Role of heat-shock proteins in infection of human adenocarcinoma cell line MCF-7 by tumor-adapted rotavirus isolates

“…To date, several oncolytic viruses have proven to be effective against some tumor cells, including animal models [7][8][9][10] , pre-clinical studies 11 and clinical trials [11][12][13] . Recent clinical trials have shown the safety, tolerability, and efficacy of some oncolytic viruses used for the treatment of cancers 14 .…”

Developmental Landscape of Potential Vaccine Candidates Based on Viral Vector for Prophylaxis of COVID-19

“…The study results suggested that poxvirus can be a promising platform when used with different antigen targets, in combination with checkpoint inhibitor, or in other disease settings (Gulley et al, 2019). Adenoviruses, when used in animal models (Lundstrom, 2017), have shown potential therapeutic effects for gastric cancer, hepatic carcinoma, prostate (Ekblad and Halldén, 2010), ovarian (Matthews et al, 2009), and brain cancer (Fu et al, 2010). Shapira et al demonstrated that adenoviral vectors encoding a proapoptotic PUMA gene regulated by RAS-responsive elements (Ets/AP1) can suppress the growth of cancer cell with KRAS mutation (Shapira et al, 2017).…”