Potential Airborne Asbestos Exposure and Risk Associated with the Historical Use of Cosmetic Talcum Powder Products

Abstract

Over time, concerns have been raised regarding the potential for human exposure and risk from asbestos in cosmetic-talc-containing consumer products. In 1985, the U.S. Food and Drug Administration (FDA) conducted a risk assessment evaluating the potential inhalation asbestos exposure associated with the cosmetic talc consumer use scenario of powdering an infant during diapering, and found that risks were below levels associated with background asbestos exposures and risk. However, given the scope and age of the FDA's assessment, it was unknown whether the agency's conclusions remained relevant to current risk assessment practices, talc application scenarios, and exposure data. This analysis updates the previous FDA assessment by incorporating the current published exposure literature associated with consumer use of talcum powder and using the current U.S. Environmental Protection Agency's (EPA) nonoccupational asbestos risk assessment approach to estimate potential cumulative asbestos exposure and risk for four use scenarios: (1) infant exposure during diapering; (2) adult exposure from infant diapering; (3) adult exposure from face powdering; and (4) adult exposure from body powdering. The estimated range of cumulative asbestos exposure potential for all scenarios (assuming an asbestos content of 0.1%) ranged from 0.0000021 to 0.0096 f/cc-yr and resulted in risk estimates that were within or below EPA's acceptable target risk levels. Consistent with the original FDA findings, exposure and corresponding health risk in this range were orders of magnitude below upper-bound estimates of cumulative asbestos exposure and risk at ambient levels, which have not been associated with increased incidence of asbestos-related disease.

Bebek ve Çocuklara Yönelik Kozmetik Ürünlerin Güvenliliği

“…Burns ve arkadaşlarının yaptığı bu çalışmada iki yıl boyunca pudralanan yenidoğanlarda akciğer kanseri ve mezotelyoma riskini değerlendirmek amacıyla 0.020 IUR (Inhalation Unit Risk) teorik risk faktörü hesaplanmıştır. Ancak, yaşam boyu kümülatif maruziyet değerleri hesaplandığında, Amerika Birleşik Devletleri'ndeki asbest risk değerlendirmesi düzenleyici modeli ile elde edilen bu teorik veri EPA'nın (Environmental Protection Agency) kanser riskine ilişkin hedef risk seviyesinin altında bulunmuştur [71].…”

Characterization of asbestos exposures associated with the use of facial makeups

“…There have been several studies that have attempted to evaluate the potential for exposures to particulates, and more specifically, asbestos, phase-contrast microscopy (PCM)countable fibers, and EMPs associated with the use of cosmetic talcum powders (E. L. Anderson et al, 2017;Aylott et al, 1979;Moon et al, 2011;Rasmussen et al, 2019;Russell et al, 1979;Steffen Tran et al, 2019). Those studies assessing exposures to asbestos specifically have shown inconsistent findings, most likely due to differences in nomenclature and analytical approaches (E. L. Anderson et al, 2017;Burns et al, 2019;Egilman et al, 2019;Gordon et al, 2014) For example, Gordon et al (2014) did not differentiate asbestos from non-asbestos amphibole EMPs because the authors stated that "it is unclear how to identify a cleavage fragment once the stone or material has been finely ground," whereas E. L. Anderson et al (2017) attempted to differentiate asbestos and non-asbestos amphibole EMPs in their analysis of air samples, although the authors also projected risk estimates assuming all EMPs were asbestos.…”

Determining Childhood Learning from Various Kind Formulas of Soft-Prepared Chalk

“…Therefore a monitoring system should be launched to reduce violence and deaths. The preventive approach to health education measurement should be increased and focused heavily on surveillance (Siribunnam et al, 2014;Burns et al, 2019;Taher et al, 2019).…”