2015
DOI: 10.1001/jamapediatrics.2015.0317
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Potential and Actual Neonatal Organ and Tissue Donation After Circulatory Determination of Death

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Cited by 36 publications
(54 citation statements)
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References 43 publications
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“…In the USA, neonatal organ donation is more established, while in the UK it is gaining momentum 95. In one US cohort, profound central nervous system injury and/or encephalopathy was the most common cause of death for potentially eligible neonatal donation after cardiac death donors 96. Importantly, despite the global hypoxia ischaemia suffered in HIE, organs such as the kidney usually recover once transplanted.…”
Section: Redirection Of Care and Organ Donationmentioning
confidence: 99%
“…In the USA, neonatal organ donation is more established, while in the UK it is gaining momentum 95. In one US cohort, profound central nervous system injury and/or encephalopathy was the most common cause of death for potentially eligible neonatal donation after cardiac death donors 96. Importantly, despite the global hypoxia ischaemia suffered in HIE, organs such as the kidney usually recover once transplanted.…”
Section: Redirection Of Care and Organ Donationmentioning
confidence: 99%
“…A US tertiary neonatal study described OD potential in 8% of deaths in tertiary US NICUs . Others describe the potential for ‘en bloc’ kidney donation in up to 26–36% of neonatal deaths . Interestingly, eligibility based on brain death determination, widely considered rare, was reported in over 10% in one neonatal audit …”
Section: Infant and Neonatal Organ Donationmentioning
confidence: 99%
“…38 Others describe the potential for 'en bloc' kidney donation in up to 26-36% of neonatal deaths. 39,40 Interestingly, eligibility based on brain death determination, widely considered rare, was reported in over 10% in one neonatal audit. 41 The challenges for neonatal OD have included diagnosing brain death, technical aspects of organ procurement and transplantation and the perception of a sparse recipient population.…”
Section: Infant and Neonatal Organ Donationmentioning
confidence: 99%
“…Following the rediscovery of BAT in human adults, there has been an extensive search for UCP1-expressing cells (13), including in EAT, which has been shown to exhibit an intermediate (or "beige") phenotype in adults (11). However, one of the most challenging aspects in unraveling the genomic changes that occur during early adipogenesis remains the practical difficulty in obtaining relevant samples from newborns and infants (14). To address this, we collected EAT biopsies from pediatric patients through collaborations with cardiac surgeons.…”
Section: Introductionmentioning
confidence: 99%