The increase in soil salinity due to human-induced processes poses a severe threat to agriculture on a regional and global scale. Soil salinization caused by natural and anthropogenic factors is a vital environmental hazard, specifically in semi-arid and arid regions of the world. The detection and monitoring of salinity are critical to the sustainability of soil management. The current study compared the performance of machine learning models to produce spatial maps of electrical conductivity (EC) (as a proxy for salinity) in an alluvial irrigation plain. The current study area is located in the Isparta province (100 km2), land cover is mainly irrigated, and the dominant soils are Inceptisols, Mollisols, and Vertisols. Digital soil mapping (DSM) methodology was used, referring to the increase in the digital representation of soil formation factors with today’s technological advances. Plant and soil-based indices produced from the Sentinel 2A satellite image, topographic indices derived from the digital elevation model (DEM), and CORINE land cover classes were used as predictors. The support vector regression (SVR) algorithm revealed the best relationships in the study area. Considering the estimates of different algorithms, according to the FAO salinity classification, a minimum of 12.36% and a maximum of 20.19% of the study area can be classified as slightly saline. The low spatial dependence between model residuals limited the success of hybrid methods. The land irrigated cover played a significant role in predicting the current level of EC.