Potential Anti-acne: Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) from Central Kalimantan-Indonesia

Abstract

Background: Research development has been carried out by exploring antimicrobial agents from herbal sources that can be further developed as anti-acne drugs. Some previous studies reported that bawang dayak has antibacterial properties. However, the study of bawang dayak as anti-acne in Indonesia was limited so that it becomes one of the reasons why this study should be developed. Objective: This study was aimed to determine the minimum inhibitory concentration (MIC) of bawang dayak ethanol extract and to determine the antibacterial activity of the chloroform fraction and the ethyl acetate fraction of bawang dayak extract. Methods: The MIC value was determinate by measured initial absorbance and final absorbance of ten variations of concentration of extract using a UV-Vis spectrophotometer. The antibacterial activity of chloroform and ethyl acetate fraction was performed using the disc diffusion technique, with five variations of concentration against P.acnes, S. epidermidis, S. aureus. Results: The decrease in absorbance value occurred at a concentration of 0.19%, 1.56% to 100%, which means that at that concentration can inhibit bacterial growth. The antibacterial activity showed that both the chloroform fraction and ethyl acetate fraction of bawang dayak extract were active against all the tested bacteria, whose inhibition zones were in the range of 5.8 ± 0.9 -23.6 ± 2.3 mm. However, the ethyl acetate fraction of bawang dayak extract showed better antibacterial activity than chloroform fraction of bawang dayak extract. Conclusion: In this study, it was found that the concentration of 0.19% is the MIC of bawang dayak extract against P. acnes. The highest antibacterial activity was produced by 20% of ethyl acetate fraction of bawang dayak extract against S. aureus.

Formulation of Anti Acne Loose Powder of Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) Ethanol Extract

“…The bulb part has been used traditionally among the Dayak community as folk medicine to treat several diseases 7, 8 . Eleutherine bulbosa was known to have antibacterial properties against acne-causing bacteria, as reported in our previous studies 9- 12 . Our other previous studies 13, 14 also reported that cream of E. bulbosa ethanol extract could inhibit the growth of P. acnes, and it does not cause significant skin adverse reactions 15, 16 .…”

Pharmacognostic Study of Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) and its Clay Mask Against Acne-Causing Bacteria

“…Urb) can inhibit acne-causing bacteria, such as S. aureus, S. epidermidis, and P. acnes. [7][8][9] Furthermore, the ethanolic extract was made into cream preparations [10][11][12][13] , showing good inhibitory abilities against acne-causing bacteria. In this study, it was developed in the form of a new product, namely a clay mask, to overcome acne vulgaris.…”

“…[5][6] Previous studies have shown that the ethanolic extract of this plant can inhibit acne-causing bacteria, such as S. aureus, S. epidermidis, and P. acnes. [7][8][9] It has also been processed into cream preparations, which has gone through a series of formulation modification experiments, primary irritation test with animals and human using the human patch test method. © 2022 the authors.…”

Modification of Anti-acne Bawang Dayak (Eleutherine bulbosa (Mill.)Urb.) Cream to Propionibacterium acnes

“…Furthermore, the formulation of the tested cream was reported separately after 3 days of storage, which may reduce P. acnes ' inhibitory potential. [ 5 6 ] This study aims to improve the quality of the anti-acne cream formulation of bawang dayak extract from previous studies. In this study, the cream formulation from previous studies was modified with the addition of honey, cinnamon, and peppermint to make the cream formulation more stable and improve its organoleptic properties, mainly to disguise the smell of bawang dayak.…”