Potential anti-diabetic activity of &lt;i&gt;Bombax ceiba&lt;/i&gt;

Bhavsar, Chetan J.; Talele, Gokul S.

doi:10.3329/bjp.v8i2.13701

Cited by 29 publications

(14 citation statements)

References 18 publications

(12 reference statements)

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“…Different parts of this plant are reported to have therapeutic potentials against different diseases such as diabetes, hepatic toxicity, infections, asthenia, polyurea and glycosuria [9][10][11][12]. Although different parts of B. ceiba are known to have different biological activities including antioxidant, antimicrobial, anti-inflammatory and analgesic, ,hypotensive and hypoglycemic activity, very little work has been done by taking an ethanolic extract of young roots of B. ceiba (BCYR) on diabetes and hepatic toxicity [9,10,[13][14][15]. Therefore, the present study was undertaken to investigate the effects of the BCYR on diabetes and hepatic toxicity in Alloxan-Induced Diabetic Mice (AIDM).…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and Hepatoprotective Activities of Bombax ceiba Young Roots in Alloxan-Induced Diabetic Mice

Sharmin¹,

Maruf-ul-Islam²,

Joarder³

et al. 2018

jnhfs

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Bombax ceiba (B. ceiba), a member of the Malvaceae family, has widely been used by rural practitioners for various ailments from ancient civilization. Although different parts of this plant are known to have several biological activities, very little is known about the effects of young roots of B. ceiba (BCYR) on diabetes and hepatic toxicity. Therefore, the present study was undertaken to investigate the effects of the BCYR on diabetes and hepatic toxicity in Alloxan-Induced Diabetic Mice (AIDM). The dried coarse powder of the BCYR was extracted with ethanol (Et-BCYR) by cold extraction method. Qualitative phytochemical screening of the Et-BCYR revealed the presence of flavonoids, phenolics, tannin, steroids, alkaloids and glycosides. Administration of the Et-BCYR (400 mg/kg bw) intraperitoneally in AIDM, it significantly (p>0.05) reduced the blood glucose level compared to untreated AIDM at different time points (0-24 hours). Strikingly, the most action was 78.36% in 16 hours, which was higher than that of the standard met for min (72.36%). Treatment with Et-BCYR significantly (p>0.0001) elevated the HDL level; on the contrary, it reduces LDL, TC and TG levels when compared to untreated AIDM. Additionally, Et-BCYR treatment significantly (p>0.0001) decreased the hepatotoxicity by detecting the reduced level of SGOT and SGPT (hepatotoxic markers) compared to untreated AIDM. Our findings show that the young roots of B. ceiba have potential hypoglycemic, hypolipidemic and hepato protective activities and confirm the traditional uses of this plant to manage diabetes and its associated liver toxicity.

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Section: Introductionmentioning

confidence: 99%

Antidiabetic and Hepatoprotective Activities of Bombax ceiba Young Roots in Alloxan-Induced Diabetic Mice

Sharmin¹,

Maruf-ul-Islam²,

Joarder³

et al. 2018

jnhfs

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“…Ethnopharmacological and ethno botanical surveys indicate that more than 1200 plants are used worldwide in herbal medicine to treat diabetes (Ziyyat et al, 1997;El-Hilaly et al, 2003;Tahraoui et al, 2007 (Prajapati et al, 2008;Ravi et al, 2009;Pattanayak et al, 2009;Tatiya et al, 2013;Bandara et al, 2009;Saha et al, 2009;Bhowmik et al, 2009;Sen et al, 2013;Khanam et al, 2009;Alamgeer et al, 2013;Bhavsar and Talele, 2013;Kulandaivel et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Antihyperlipidemic and renoprotective activities of methanolic extract of <i>Canscora decussata</i> extract in alloxan-induced diabetic rabbits

Irshad

Akhtar

Kamal

et al. 2013

Bangladesh J Pharmacol

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The current study was designed to evaluate the hypolipidemic and renoprotective effects of methanolic extract of powdered Canscora decussata whole plant in the diabetic rabbits. Thirty rabbits were divided into five groups having 6 animals each including normal and diabetic controls groups, the remaining groups received methanolic extract in 400 and 600 mg/kg doses and another group got pioglitazone (3 mg/kg) for 30 days. Serum levels of triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, albumin, globulin and total proteins were estimated by using commercially available kits. The results showed that extract significantly (p<0.01) decreased the raised parameters including triglyceride, total cholesterol and LDL-cholesterol, atherogenic index, Coronary risk index up to normal values compared to diabetic rabbits. However, it significantly increased HDL-cholesterol, albumin, globulin and total protein levels. Therefore, it is suggested that methanolic extract of C. decussata exerts hypolipidemic and renoprotective effects in the alloxan-induced diabetic rabbits. Article Info

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“…[ 176 ]. However, at 600 mg/kg dose the extract could significantly decrease elevated levels of blood glucose in diabetic rats [ 178 ].…”

Section: Pharmacological Potential Of Bombacoideaementioning

confidence: 99%

Systematics, Phytochemistry, Biological Activities and Health Promoting Effects of the Plants from the Subfamily Bombacoideae (Family Malvaceae)

Das

Shin

Ningthoujam³

et al. 2021

Plants

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Plants belonging to the subfamily Bombacoideae (family Malvaceae) consist of about 304 species, many of them having high economical and medicinal properties. In the past, this plant group was put under Bombacaceae; however, modern molecular and phytochemical findings supported the group as a subfamily of Malvaceae. A detailed search on the number of publications related to the Bombacoideae subfamily was carried out in databases like PubMed and Science Direct using various keywords. Most of the plants in the group are perennial tall trees usually with swollen tree trunks, brightly colored flowers, and large branches. Various plant parts ranging from leaves to seeds to stems of several species are also used as food and fibers in many countries. Members of Bombacoides are used as ornamentals and economic utilities, various plants are used in traditional medication systems for their anti-inflammatory, astringent, stimulant, antipyretic, microbial, analgesic, and diuretic effects. Several phytochemicals, both polar and non-polar compounds, have been detected in this plant group supporting evidence of their medicinal and nutritional uses. The present review provides comprehensive taxonomic, ethno-pharmacological, economic, food and phytochemical properties of the subfamily Bombacoideae.

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Potential anti-diabetic activity of <i>Bombax ceiba</i>

Cited by 29 publications

References 18 publications

Antidiabetic and Hepatoprotective Activities of Bombax ceiba Young Roots in Alloxan-Induced Diabetic Mice

Antidiabetic and Hepatoprotective Activities of Bombax ceiba Young Roots in Alloxan-Induced Diabetic Mice

Antihyperlipidemic and renoprotective activities of methanolic extract of <i>Canscora decussata</i> extract in alloxan-induced diabetic rabbits

Systematics, Phytochemistry, Biological Activities and Health Promoting Effects of the Plants from the Subfamily Bombacoideae (Family Malvaceae)

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