Potential Anti-HIV Agents from Marine Resources: An Overview

Vo, Thanh‐Sang; Kim, Se‐Kwon

doi:10.3390/md8122871

Cited by 154 publications

(119 citation statements)

References 113 publications

(113 reference statements)

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“…Some of these plantsderived antiretroviral therapies have been shown to have inhibitory activities against several HIV-1 processes, including viral entry, reverse transcription, replication, integration, virus maturation and virion budding. Some of these compounds have been clinically tested, with favourable results (Asres et al, 2005;Park et al, 2009;Vo and Kim, 2010;Jiang et al, 2010;Filho et al, 2010;Sing and Bodiwala, 2010).…”

Section: Discussionmentioning

confidence: 99%

Extracts of Moringa oleifera Lam. showing inhibitory activity against early steps in the infectivity of HIV-1 lentiviral particles in a viral vector-based screening

Nworu¹,

C²,

Okoye³

et al. 2013

Afr. J. Biotechnol.

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Section: Discussionmentioning

confidence: 99%

Extracts of Moringa oleifera Lam. showing inhibitory activity against early steps in the infectivity of HIV-1 lentiviral particles in a viral vector-based screening

Nworu¹,

C²,

Okoye³

et al. 2013

Afr. J. Biotechnol.

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“…Therefore, many research groups are being required to search for novel anti-HIV agents compatible to those of developed countries. Marine-based natural products that have chemically diverse and unique structures have received attention as sources for the development of new anti-HIV agents (Vo and Kim, 2010). Marine materials such as phlorotannins, sulfated chitoolifosaccharides, sulfated polysaccharides, and lectin have been reported to have anti-HIV activities.…”

Section: Introductionmentioning

confidence: 99%

A Spirulina maxima-derived peptide inhibits HIV-1 infection in a human T cell line MT4

Jang

Park

2016

Fish Aquatic Sci

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Human immunodeficiency virus (HIV) is the causative agent of acquired immune deficiency syndrome (AIDS). Anti-HIV agents targeting various steps in HIV life cycle have been developed; however, so far, no effective drugs have been found. We show here that a peptide isolated from Spirulina maxima (SM-peptide) inhibits HIV-1 infection in a human T cell line MT4. SM-peptide inhibited HIV-1 IIIB -induced cell lysis with a half-maximal inhibitory concentration (IC 50 ) of 0.691 mM, while its 50 % cytotoxic concentration (CC 50 ) was greater than 1.457 mM. Furthermore, the SMpeptide inhibited the HIV-1 reverse transcriptase activity and p24 antigen production. This suggests that SM-peptide is a novel candidate peptide, which may be developed as a therapeutic agent for acquired immunodeficiency syndrome patients.

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“…The nutritional benefits of fish consumption are due to the presence of proteins, unsaturated essential fatty acids, minerals (for example, calcium, iron, selenium and zinc), and vitamins, namely Vitamin A, B3, B6, B12, E and D. Research has also shown that peptides derived from fermented fish following enzymatic treatment may be useful therapeutics for the treatment of many common acute and chronic diseases such as viral infections, hypertension, cancer and Alzheimer's disease [7]. Fish collagen may also be used in bone treatment as an alternative to mammalian collagen which is known to be immunogenic [8].…”

Section: Marine Fishmentioning

confidence: 99%

Marine Organisms as Biomedical Resources Enrich Quality of Life

Somavarapu¹

2017

CBB

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Abstract:The Ocean, called the 'mother of origin of life', is a rich source of biological and chemical diversity. Marine floras include microflora (bacteria, actinobacteria, cyanobacteria and fungi), microalgae, macroalgae (seaweeds), and flowering plants (mangroves and other halophytes). Marine organisms have unique properties as they are exposed to extreme marine environmental conditions. This vast marine floral resource offer a great way for discovery of new drugs which can fight deadly diseases like cancer, acquired immune deficiency syndrome (AIDS), arthritis, etc. Sea has got plenty of metabolites and other resources in living or dead form. Thermo-stable proteases, lipases, esterases, and starch and xylan degrading enzymes have been actively sought from bacterial and archaeal hyperthermophilic marine microorganisms. Marine cyanobacteria appear to be potential sources for production of vitamins such as B complex group and vitamin-E. The carotenoids and phycobiliprotein pigments of cyanobacteria have commercial value as natural food colouring agents, as feed additives, as enhancers of the color of egg yolks, to improve the health and fertility of cattle, as drugs and in the cosmetic industries. Some anti-HIV activity has been observed with the compounds extracted from Lyngbya lagerhaimanii and Phormidium tenue. Thus an attempt to review few marine derived biomedical resources was done emphasizing that with the advent of modern technologies it is anticipated that the marine environment will become an invaluable source of novel compounds in the future.

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Potential Anti-HIV Agents from Marine Resources: An Overview

Cited by 154 publications

References 113 publications

Extracts of Moringa oleifera Lam. showing inhibitory activity against early steps in the infectivity of HIV-1 lentiviral particles in a viral vector-based screening

Extracts of Moringa oleifera Lam. showing inhibitory activity against early steps in the infectivity of HIV-1 lentiviral particles in a viral vector-based screening

A Spirulina maxima-derived peptide inhibits HIV-1 infection in a human T cell line MT4

Marine Organisms as Biomedical Resources Enrich Quality of Life

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