Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol

Jung, Young Yun; Hwang, Sun Tae; Sethi, Gautam; Fan, Li; Arfuso, Frank; Ahn, Kwang Seok

doi:10.3390/molecules23112827

Cited by 112 publications

(76 citation statements)

References 52 publications

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“…Furthermore, cyanobacteria provide the native potential for synthesis of isoprenoids or terpenes whose precursors are pyruvate and GAP. Some terpenes are promising compounds in cancer therapy and inhibit essential enzymes in tumor formation in a variety of cancer types (33)(34)(35). In addition, genetically engineered cyanobacteria can be used for the synthesis of heterologous compounds such as n-butanol.…”

Section: Discussionmentioning

confidence: 99%

The Novel PII-Interacting Regulator PirC (Sll0944) Identifies 3-Phosphoglycerate Mutase (PGAM) as Central Control Point of Carbon Storage Metabolism in Cyanobacteria

Orthwein

Scholl

Spaet

et al. 2020

Preprint

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Nitrogen limitation imposes a major transition in the life-style of non-diazotrophic cyanobacteria, which is regulated via a complex interplay of regulatory factors, involving, the nitrogen-specific transcription factor NtcA and the pervasive signal processor PII. Immediately upon nitrogen-limitation, newly fixed carbon is re-directed towards glycogen synthesis. How the metabolic switch for distributing fixed carbon to either glycogen or cellular building blocks is operated was poorly understood. Here we identify from Synechocystis sp. PCC 6803 a novel PII interactor, PirC, (Sll0944) that controls 3-phosphoglycerate mutase (PGAM), the enzyme that deviates newly fixed CO2 towards lower glycolysis. PirC acts as competitive inhibitor of PGAM and this interaction is tuned by PII/2-oxoglutarate. High oxoglutarate release PirC from PII-complex to inhibit PGAM. Accordingly, PirC deficient mutant, as compared to the wild-type, shows strongly reduced glycogen levels upon nitrogen deprivation whereas polyhydroxybutyrate granules are over-accumulated. Metabolome analysis revealed an imbalance in 3-phosphoglycerate to pyruvate levels in the PirC mutant, conforming that PirC controls the carbon flux in cyanobacteria via mutually exclusive interaction with either PII or PGAM.

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Section: Discussionmentioning

confidence: 99%

The Novel PII-Interacting Regulator PirC (Sll0944) Identifies 3-Phosphoglycerate Mutase (PGAM) as Central Control Point of Carbon Storage Metabolism in Cyanobacteria

Orthwein

Scholl

Spaet

et al. 2020

Preprint

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“…Farnesol has an anti-obesity effect in high fat diet-induced obese mice and induces the development of beige adipocytes in human adipose tissue-derived mesenchymal stem cells [ 129 ]. This compound has potential anti-inflammatory and anti-cancer properties [ 130 ]. Cardioprotection by farnesol includes the role of the mevalonate pathway [ 131 ].…”

Section: Terpenoids As Potential Geroprotectorsmentioning

confidence: 99%

Terpenoids as Potential Geroprotectors

et al. 2020

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Terpenes and terpenoids are the largest groups of plant secondary metabolites. However, unlike polyphenols, they are rarely associated with geroprotective properties. Here we evaluated the conformity of the biological effects of terpenoids with the criteria of geroprotectors, including primary criteria (lifespan-extending effects in model organisms, improvement of aging biomarkers, low toxicity, minimal adverse effects, improvement of the quality of life) and secondary criteria (evolutionarily conserved mechanisms of action, reproducibility of the effects on different models, prevention of age-associated diseases, increasing of stress-resistance). The number of substances that demonstrate the greatest compliance with both primary and secondary criteria of geroprotectors were found among different classes of terpenoids. Thus, terpenoids are an underestimated source of potential geroprotectors that can effectively influence the mechanisms of aging and age-related diseases.

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“…Among aromatic compounds, phenylpropanoids are major volatiles and benzenoids are minor volatiles (25,68). Most of these sesquiterpene alcohols, such as farnesol, have been reported to exhibit anti-cancer and anti-inflammatory effects, and also alleviate allergic asthma, gliosis and edema (69). These can lead to the discovery of new natural drugs with potential uses as anticancer agents.…”

Section: Transcription Factors (Tfs) As Key Roles In Regulating the Ementioning

confidence: 99%

A Review on Cyclamen Species: Transcription Factors vs. Pharmacological Effects

Cornea-Cipcigan¹,

Pamfil²,

Sisea³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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The mechanism of floral mutation including double flowers in plant species can be explained by the ABCDE model which represents the relationship between MADS-box transcription factor genes and floral morphogenesis. The ornamental importance of Cyclamen led to the creation of double-flowered cultivars caused by the repression of AG-like gene expression in whorl 3. Modifications in these genes also influence the accumulation of different bioactive compounds depending on species and/or variety. In antiquity, cyclamen plants were recognized for their therapeutic qualities and later gained importance due to their content in saponins, which have been reported to exhibit anti-cancer, anti-inflammatory and antibacterial effects, and also to alleviate symptoms in acute rhinosinusitis patients. Furthermore, the extracts and isolated compounds are used as treatments in a wide range of diseases. In this review, we describe the transcription factors and their role in the development and ABCDE model formation of organs which led to the development of double-petal and fragrant varieties. Additionally, we describe the potential mechanisms of action underlying the therapeutic effects of saponin extracts against cancers and inflammatory disorders and their potential as a pharmacological agent in clinical studies.

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Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol

Cited by 112 publications

References 52 publications

The Novel PII-Interacting Regulator PirC (Sll0944) Identifies 3-Phosphoglycerate Mutase (PGAM) as Central Control Point of Carbon Storage Metabolism in Cyanobacteria

The Novel PII-Interacting Regulator PirC (Sll0944) Identifies 3-Phosphoglycerate Mutase (PGAM) as Central Control Point of Carbon Storage Metabolism in Cyanobacteria

Terpenoids as Potential Geroprotectors

A Review on Cyclamen Species: Transcription Factors vs. Pharmacological Effects

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