Potential Antibacterial Activity of Marine Macroalgae against Pathogens Relevant for Aquaculture and Human Health

Rizzo, Carmen; Genovese, Giuseppa; Morabito, Marina; Faggio, Caterina; Pagano, Maria; Spanò, Antonio; Zammuto, Vincenzo; Minicante, Simona Armeli; Manghisi, Antonio; Cigala, Rosalia Maria; Crea, Francesco; Marino, Fabio; Gugliandolo, Concetta

doi:10.22207/jpam.11.4.07

Cited by 35 publications

(21 citation statements)

References 43 publications

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“…Saritha et al (37) reported the antibacterial effects of the fatty acid fractions from three different macroalgae. Results of this research are in accordance with the study of Rizzo et al (38) that showed the antibacterial activity of ethanol F. virsoides crude extract and isolated polysaccharides.…”

Section: Discussionsupporting

confidence: 92%

Seasonal variation in biopharmaceutical activity and fatty acid content of endemic Fucus virsoides algae from Adriatic Sea

Grozdanić¹,

Zdunić²,

Šavikin³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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Fucus virsoides J. Agardh is an endemic brown alga found only in the Adriatic Sea. Other members of the Fucus genus have shown anticancer potential, namely F. vesiculosus L. (1) and its most active component fucoidan. Algae from the Fucus genus are rich in active biological compounds such as polysaccharides, polyphenols, fatty acids and vitamins (2). Fucoidans have been documented for numerous biological activities such as antiviral, anti-inflammatory, anticoagulant, anti-angiogenic, immunomodulatory, and anti-adhesive activities (3, 4). The biological effects of these compounds can vary due to chemical structure differences that depend on the species from which they have been isolated (3). The anticancer or antidiabetic properties of Fucus virsoides have not been investigated in detail. Polyphenols, secondary metabolites, have been studied for their role in the prevention of cancer, diabetes, cardiovascular diseases, osteoporosis, and neurodegenerative diseases. Polyphenols exert antioxidant, free radical scavenging activities; they

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Section: Discussionsupporting

confidence: 92%

Seasonal variation in biopharmaceutical activity and fatty acid content of endemic Fucus virsoides algae from Adriatic Sea

Grozdanić¹,

Zdunić²,

Šavikin³

et al. 2019

Acta Poloniae Pharmaceutica - Drug Research

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“…Further, the yield of extractable materials and antimicrobials from different seaweed species depend on the solvent type. Antibacterial potential of algae against fish pathogens was reported in other studies (Rizzo et al, 2017;Saleh & Al-Mariri, 2017). Natural factors, such as environmental conditions (climate, location, salinity, and temperature), pollution, the life stage, reproductive state, growth conditions, age of the seaweed as well as collection time and epiphytic organisms affect the chemical composition and antimicrobial activity of seaweeds revealing that this activity is not attributed to a single compound, but it could be related to some of them and to a combination of metabolites (Trigui et al, 2013;Stabili et al, 2014;Pérez et al, 2016).…”

Section: Antibacterial Activity Of the Seaweed Extractssupporting

confidence: 61%

“…Oliveira et al (2014) stated that addition of the brown algae Ascophyllum nodosum as meals to the diet of Nile tilapia infected with A. hydrophila enhanced the sanitary status of the fish and occurrence of the infection was lower. Previous studies reported in vivo antibacterial activity of water, methanol and dichloromethane extracts of different algal species against Vibrio anguillarum, Aeromonas salmonicida, Pseudomonas anguilliseptica, A. hydrophila, Yersinia ruckeri, and shrimp Vibrio pathogens for aquaculture sanitary (Bansemir et al, 2006, Manilal et al, 2012Rizzo et al, 2017;Wan et al, 2018).…”

Section: Applications Of the Encapsulated Extracts Efficiency Of The mentioning

confidence: 99%

GC/MS identification and applications of bioactive seaweed extracts from Mediterranean coast of Egypt

Hassan

Shobier

2018

Egypt. J. of Aquatic Biolo. and Fish.

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The antibacterial activity of different seaweed species against five fish pathogens (A. hydrophila, V. parahaemolyticus, V. alginolyticus, V. damsela and Vibrio sp.) has been evaluated. The ethanolic extract of C. sinuosa (CSE1) and dichloromethane extract of C. officinalis (COM) exhibited the highest antibacterial activity with activity index (AI) = 1.4 ±0.74 and 1.2 ±0.71, respectively. When the extracts were encapsulated into calcium alginate beads their antibacterial activity against the most susceptible bacterial pathogens showed that the significant growth inhibition was against V. parahaemolyticus after 5 min post addition of the beads recording 1.4 and 2 fold decrease in the growth, respectively. Recycling of the (CA/COM) beads was carried out for 7 successive cycles with success in elimination of V. parahaemolyticus. The potential applications of encapsulated extracts for elimination of microbial load in fish rearing water and antifouling activity were proved in the current investigation. The chemical composition of the bioactive extracts (CSE1) and (COM) was determined using GC/MS analysis which revealed the presence of several constituents that have been reported to exhibit antimicrobial activity. Additionally, the dichloromethane extract (COM) produced six major components including n-nonadecane, 1,2,3propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester, 2-methylhexadecan-1-ol, 1-docosene, 1-eicosanol and chloroacetic acid, octadecyl ester. However, the ethanolic extract (CSE1) was characterized by the presence of fatty acids, fatty acids ethyl esters and aromatic hydrocarbon where the most abundant compound was n-tridecanoic acid ethyl ester.

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“…If we can consider the research of marine invertebrate as source of BS-producing bacteria at an initial phase, the exploitation of these matrices for isolation of EPS producers is located at a nascent phase, with still few reports. It is limited to the use of marine vegetable organisms as direct source of exopolysaccharides [186,187], or to the use of extremophilic strains that were isolated from natural samples, the issue more widely treated [117,157,160,188]. Contrastingly, the focusing in their associated bacterial communities with producing capacity was poorly improved.…”

Section: Extracellular Polymeric Substances (Epss)mentioning

confidence: 99%

Marine Invertebrates: Underexplored Sources of Bacteria Producing Biologically Active Molecules

Rizzo

Giudice

2018

Diversity

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The marine bioprospecting could be considered as a new phenomenon, and already potentially more promising than terrestrial one in terms of possible discovery of new compounds. The secondary metabolites produced by associated-bacteria are actually studied for their remarkable role in several fields, including agricultural, industrial, medical, and bioremediation strategies against different contaminants. The use of such renewable sources could be helpful in the streamlining of the patenting process for natural compounds of good quality, produced with lower energy costs and less impact on the environment. Anyway, more improvements in the research and application of bioactive compounds as alternative to the synthetic counterparts have to be carried out for the costs reduction and the large-scale production upgrading. The use of marine invertebrates could help to overcome these difficulties, as hotspots of microbial diversity and favorable matrix for the development of conditions stimulating the production of substances with special activities. This review will deal with the current accepted definitions and recent advances concerning: (i) the marine symbiotic relationships in which microorganisms and invertebrates are involved; (ii) the principal taxa of marine invertebrates that establish interactions with microorganisms, the biodiversity of these latter, and their role in the symbiosis; (iii) we address the state of current literature and knowledge about the bacterial associated communities specialized in biosurfactants (BSs) and extracellular polymeric substances (EPSs) production; and, (iv) their potential biotechnological applications reported still now.

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Potential Antibacterial Activity of Marine Macroalgae against Pathogens Relevant for Aquaculture and Human Health

Cited by 35 publications

References 43 publications

Seasonal variation in biopharmaceutical activity and fatty acid content of endemic Fucus virsoides algae from Adriatic Sea

Seasonal variation in biopharmaceutical activity and fatty acid content of endemic Fucus virsoides algae from Adriatic Sea

GC/MS identification and applications of bioactive seaweed extracts from Mediterranean coast of Egypt

Marine Invertebrates: Underexplored Sources of Bacteria Producing Biologically Active Molecules

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