Potential anticancer agents. I. Synthesis of some nitrogen mustard containing benzylidenehydrazides

Design and Synthesis of Bis-amide and Hydrazide-containing Derivatives of Malonic Acid as Potential HIV-1 Integrase Inhibitors

“…Similar to the afore-mentioned synthetic strategy for bis-amides 1a-h , hydrazides 3a-e were synthesized by condensation of the amido ester 11 with the corresponding hydrazine 12a-e in ethanol [ 17 ] or chlorobenzene [ 18 ] under reflux, although a slight modification in the procedure for 3f was required ( Scheme 4 ).…”

Benzylidene hydrazides as potential anticancer agents

“…h Recrystallization from MeCN. 3 All compounds were analyzed for C, II, X. idene Hydrazides.-In a typical reaction, 3.06 g (0.01 mol) of A"-(4-bromophenyl)anthranilic acid hydrazide, 2.46 g (0.0 L mol 1 of p-,V,A'-bis(2-chloroethyl)aminobenzaldehyde in 40 ml of EtOH containing 1 drop of HOAc were refluxed for 4 hr. The reaction mixture was cooled, the precipitate filtered to yield 5.1 g of crude material, mp 195-199°. Iiecrystallization from MeCN raised the melting point to 198-199.5°. Some Substituted [p-(p-Ethoxyphenyl)anilino]acetamides G. Bhancacuio, G. Lktokhi, A. Larizza.…”