Potential anticancer agents. Nitrogen mustards of aminophenylthiazoles

Jd, Modi; Ss, Sabnis; Cv, Deliwala

doi:10.1021/jm00291a030

Cited by 6 publications

(2 citation statements)

References 3 publications

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“…Compound 3 has been shown to exhibit inhibitory efficacy against leukemia P‐388, as measured by the ratio of the test animal (T) to the mean survival time (C) for the control. With (T/C) values of 150 or above, the median survival time of the control group is 30 days [13] …”

Section: The First Decade (1970–1980)mentioning

confidence: 99%

Thiazole as an Indispensable Scaffold in Anti‐Leukemic Agents: A Semicentennial Review

Sharma,

Das,

Jadhav

et al. 2024

ChemistrySelect

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Leukemia affects the body‘s blood‐forming tissues, especially the bone marrow and lymphatic system. Leukemia incidence varies between communities and between pathological kinds. Many treatment modalities exist for leukemia, such as chemotherapy, targeted therapy, radiation therapy, bone marrow transplantation, immunotherapy, and the engineering of immune cells to fight leukemia. Leukemia might be treated with a variety of pharmaceuticals, the most popular of which are imatinib (Gleevec), dasatinib (Sprycel), nilotinib (Tasigna), obinutuzumab (Gazyva), venetoclax (Venclexta), and so on. Thiazole is one of the scaffolds that are actively explored in leukemia. Derivatives having the thiazole nucleus have been surfacing as potent candidates in the treatment of leukemia for quite sometime now, but a consolidated report accumulating all these ventures is absent. Numerous naturally occurring substances, including flavones, alkaloids, anabolic steroids, and vitamin B1 (thiamine), include the basic thiazole molecule. Thiazole derivatives have been researched for their possible therapeutic effects in the treatment of leukemia. Thus, this review comprising reports regarding the effect of different thiazole‐based species in leukemia is a timely effort to the best of our knowledge. This review covers the chronological development of antileukemic thiazole‐based molecules, their synthesis, biological activity, and structure–activity relationships.

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Section: The First Decade (1970–1980)mentioning

confidence: 99%

Thiazole as an Indispensable Scaffold in Anti‐Leukemic Agents: A Semicentennial Review

Sharma,

Das,

Jadhav

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

show abstract

“…The anthelmintic property of 2-( 4-thiazolyl)benzimidazole (thiabendazole) is well recognised for the control of gastrointestinal nematodes of ruminants. 2-Amino-3-nitrothiazole and its Nacyl derivatives are the first family of compounds to show definite activity (in vivo) against 5 ) Trichomonas in mice. The antitumour property of the Schiff's bases, prepared from benzaldehyde nitrogen mustard and 2-phenyl-4-(3-amino-4-methoxy phenyl) thiazole has also been noticed.…”

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confidence: 99%