Potential Anticancer Agents.<sup>1</sup> XXIV. Tetrahydroquinazoline Analogs of Tetrahydrofolic Acid. II.

DeGraw, Joseph I.; Goodman, Leon; Koehler, R.; Baker, B. R.

doi:10.1021/jo01093a004

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1962

1995

Publication Types

Select...

Article3

Other3

Relationship

Self Cite1

Independent5

Authors

Journals

Cited by 7 publications

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All aqueous layers were combined, washed with 20 ml. of ether, and adjusted to pH [7][8] with glacial acetic acid. The turbid solution was saturated with sodium chloride and extracted with four 20-ml.…”

mentioning

confidence: 99%

Potential Anticancer Agents.¹ LXIX. Tetrahydroquinazoline Analogs of Tetrahydrofolic Acid. IV. The Synthesis of 5,8-Dideaza-5,6,7,8-tetrahydroaminopterin

DeGraw¹,

Goodman²,

Weinstein³

et al. 1962

J. Org. Chem.

Self Cite

View full text Add to dashboard Cite

The direct fusion of 4-oxocyclohexanecarboxaldehyde dimethyl acetal (III) with cyanoguanidine provided the key intermediate, 2,4-diacetamido-5,6,7,8-tetrahydro-6-quinazolinecarboxaldehyde (XV), necessary for the synthesis of 5,8-dideaza-5,6,7,8-tetrahydroaminopterin (Ila). The conversion of XV to Ila was accomplished by the reductive alkylation of p-aminobenzoyl-L-glutamic acid with XV, followed by hydrolysis of the blocked intermediate XVIII to give the crystalline and chromatographically homogeneous Ila.

show abstract

mentioning

confidence: 99%

Potential Anticancer Agents.¹ LXIX. Tetrahydroquinazoline Analogs of Tetrahydrofolic Acid. IV. The Synthesis of 5,8-Dideaza-5,6,7,8-tetrahydroaminopterin

DeGraw¹,

Goodman²,

Weinstein³

et al. 1962

J. Org. Chem.

Self Cite

View full text Add to dashboard Cite

show abstract

Naturally Occurring and Biologically Active Quinazolines

1967

Chemistry of Heterocyclic Compounds: A Series of Monographs

View full text Add to dashboard Cite

The Reduced Quinazolines

1967

Chemistry of Heterocyclic Compounds: A Series of Monographs

View full text Add to dashboard Cite

Potential Anticancer Agents.¹ XXIV. Tetrahydroquinazoline Analogs of Tetrahydrofolic Acid. II.

Cited by 7 publications

References 1 publication

Potential Anticancer Agents.¹ LXIX. Tetrahydroquinazoline Analogs of Tetrahydrofolic Acid. IV. The Synthesis of 5,8-Dideaza-5,6,7,8-tetrahydroaminopterin

Potential Anticancer Agents.¹ LXIX. Tetrahydroquinazoline Analogs of Tetrahydrofolic Acid. IV. The Synthesis of 5,8-Dideaza-5,6,7,8-tetrahydroaminopterin

Naturally Occurring and Biologically Active Quinazolines

The Reduced Quinazolines

Contact Info

Product

Resources

About

Potential Anticancer Agents.1 XXIV. Tetrahydroquinazoline Analogs of Tetrahydrofolic Acid. II.

Cited by 7 publications

References 1 publication

Potential Anticancer Agents.1 LXIX. Tetrahydroquinazoline Analogs of Tetrahydrofolic Acid. IV. The Synthesis of 5,8-Dideaza-5,6,7,8-tetrahydroaminopterin

Potential Anticancer Agents.1 LXIX. Tetrahydroquinazoline Analogs of Tetrahydrofolic Acid. IV. The Synthesis of 5,8-Dideaza-5,6,7,8-tetrahydroaminopterin

Naturally Occurring and Biologically Active Quinazolines

The Reduced Quinazolines

Contact Info

Product

Resources

About

Potential Anticancer Agents.¹ XXIV. Tetrahydroquinazoline Analogs of Tetrahydrofolic Acid. II.

Potential Anticancer Agents.¹ LXIX. Tetrahydroquinazoline Analogs of Tetrahydrofolic Acid. IV. The Synthesis of 5,8-Dideaza-5,6,7,8-tetrahydroaminopterin

Potential Anticancer Agents.¹ LXIX. Tetrahydroquinazoline Analogs of Tetrahydrofolic Acid. IV. The Synthesis of 5,8-Dideaza-5,6,7,8-tetrahydroaminopterin