Potential Antifibrotic and Angiostatic Impact of Idebenone, Carnosine and Vitamin E in Nano-Sized Titanium Dioxide-Induced Liver Injury

Abdel-Azim, S.; Darwish, Hebatallah A.; Ali, Sanaa A.; Rizk, Maha Z.; Kadry, Mai O.

doi:10.1159/000374041

Cited by 32 publications

(17 citation statements)

References 40 publications

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“…The activities of antioxidant enzymes, including catalase, SOD and GPx, were increased by vitamin E in the liver of ethanol-administered rats [140]. Furthermore, it was shown that vitamin E decreased liver fibrosis in male Wistar albino mice-treated with nano-sized titanium dioxide (n-TiO 2 ), a metallic nanoparticle generating inflammatory responses, apoptosis and necrosis via the stimulation of ROS production [143].…”

Section: Food Components For the Prevention Of Liver Fibrosismentioning

confidence: 99%

Food components with antifibrotic activity and implications in prevention of liver disease

Bae

Park

Lee

2018

The Journal of Nutritional Biochemistry

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Increasing prevalence of nonalcoholic fatty liver disease (NAFLD) in parallel with the obesity epidemic has been a major public health concern. NAFLD is the most common chronic liver disease in the United States, ranging from fatty liver to steatohepatitis, fibrosis and cirrhosis in the liver. In response to chronic liver injury, fibrogenesis in the liver occurs as a protective response; however, prolonged and dysregulated fibrogenesis can lead to liver fibrosis, which can further progress to cirrhosis and eventually hepatocellular carcinoma. Interplay of hepatocytes, macrophages and hepatic stellate cells (HSCs) in the hepatic inflammatory and oxidative milieu is critical for the development of NAFLD. In particular, HSCs play a major role in the production of extracellular matrix proteins. Studies have demonstrated that bioactive food components and natural products, including astaxanthin, curcumin, blueberry, silymarin, coffee, vitamin C, vitamin E, vitamin D, resveratrol, quercetin and epigallocatechin-3-gallate, have antifibrotic effects in the liver. This review summarizes current knowledge of the mechanistic insight into the antifibrotic actions of the aforementioned bioactive food components.

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Section: Food Components For the Prevention Of Liver Fibrosismentioning

confidence: 99%

Food components with antifibrotic activity and implications in prevention of liver disease

Bae

Park

Lee

2018

The Journal of Nutritional Biochemistry

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“…Different superscript letters in the same row indicate significant differences at p < 0.05. fibrosis factors that arise from the Kupffer cells and endothelial cells. These factors are responsible for increasing collagen synthesis 1, 3, and 4; therefore, increased expression of such factors is common in cases of the fibrosis and the necrosis accompanied by inflammation, it plays an important role in the fibrogenesis (Chobert et al 2012;Abdelazim et al 2015). Our results regarding the effects of Ag-BSEPS administration revealed significantly reduced concentrations of TNF-α, IL-6, IL-1β, and TGF-β, compared to the TAA group.…”

Section: Discussionmentioning

confidence: 51%

Effect of nanopolysaccharide (BSEPS) from Bacillus subtilis sp. on thioacetamide-induced liver fibrosis in rats

et al. 2019

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Background: Nanomedicine contributes to the efficiency of pharmacological treatments and progresses rapidly. The present study was designed to produce exopolysaccharide (BSEPS) from Bacillus subtilis sp. strain reported in our previous study was further characterized, and its BSEPS for synthesis of the nanoparticle Ag-BSEPS using microwave heating to determine the possible effects of a prepared solution containing Ag-BSEPS versus thioacetamide (TAA) evoked liver fibrosis in Wister albino rats. Nanoparticles with silver (Ag) core have been synthesized in an aqueous solution after exposure of BSEPS to periodate oxidation. Animals were split into four groups: I-control rats, water ad libitum for 6 weeks; II-rats were injected with TAA 200 mg/kg-1 3 times/week for 4 weeks IP; III-Ag-BSEPS 100 mg/kg-1 IP twice a week for 6 weeks; and IV-TAA, as group II followed by Ag-BSEPS as group III. The antifibrotic effects of Ag-BSEPS were appraised by determining different hepatotoxicity indices, oxidative stress, and inflammatory and liver fibrosis markers. Results: Nanoparticles were obtained with a diameter size range of 50-100 nm characterized by SEM and TEM without using any harmful reagents. Results evinced considerably reduced activity of liver functions such as transaminases (AST, ALT), gamma-glutamyl transferase (GGT), and alkaline phosphatase (ALP) in the group which received TAA followed by Ag-BSEPS compared to the other group which received only TAA. In the current results, the administration of Ag-BSEPS showed an improvement in the proinflammatory cytokines. On the contrary, the antioxidant enzymes in liver homogenates revealed significant improvement (concentration of glutathione peroxidase (GSH-PX), superoxide dismutase (SOD), and catalase (CAT) increases) in animals with TAA-induced liver damage followed by Ag-BSEPS. Moreover, the activities of the fibrotic markers transforming growth factor-beta 1(TGF-β1) and type III pro-collagen (PCIII) were increased in liver tissues in the group which was given TAA alone as compared to the controls. The percentage of fibrosis of hepatic tissue had a positive correlation with the levels of PCIII and TGF-β1, followed by Ag-BSEPS compared to the TAA group without nanocomposite treatment. Microscopic examinations revealed inhibitory effects of Ag-BSEPS on inflammatory changes and deterrent of liver fibrosis. Conclusion: It was suggested that the biochemical and histological amelioration observed in Ag-BSEPS (100 mg/kg-1 twice a week for 6 weeks) treated the fibrotic rats.

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“… 31 The obtained results showed that S.nit toxicity produced a marked upregulation in the Flt-1 level, which was downregulated by L-argin, carno, or their combination. Abdelazim et al 32 reported that carno downregulated the overexpression of flt-1, Smad-2, IL-6, and TNF-α and the angiogenic factor VEGF in response to n-TiO 2 intoxication.…”

Section: Discussionmentioning

confidence: 99%

Downregulation of flt-1 and HIF-1α Gene Expression by Some Antioxidants in Rats Under Sodium Nitrite–Induced Hypoxic Stress

et al. 2018

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This study assessed the effect of L-arginine (L-argin), carnosine (carno), or their combination in the amelioration of certain biochemical indices induced in the liver of hypoxic rats. Hypoxia was induced via sodium nitrite (S.nit) injection at a dose of 75 mg/kg. Rats were administered L-argin (250 mg/kg) or carno (250 mg/kg), either alone or in combination, 24 hours and 1 hour prior to S.nit intoxication. Hypoxia significantly elevated serum alanine aminotransferase, in addition to a significant upregulation of hepatic heat shock protein 70 with concurrent reduction in the level of vascular endothelial growth factor. Moreover, hepatic vascular endothelial growth factor 1 (flt-1), hypoxia inducible factor-1α gene expression, and cytochrome P450 levels were elevated, compared with the normoxic group. The antioxidants, administered either alone or in combination, markedly downregulated all of the previously mentioned biomarkers, compared to the hypoxic rats. Histopathological examination revealed hepatocellular degeneration and nuclear pyknosis, in addition to inflammatory cellular infiltration in the hypoxic rats, whereas treatment with the studied antioxidants improved the liver architecture. The present data revealed the efficacy of L-argin and carno in ameliorating the hepatic damage induced via angiogenic markers in response to hypoxia, the combination regimen showing the superior effect.

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Potential Antifibrotic and Angiostatic Impact of Idebenone, Carnosine and Vitamin E in Nano-Sized Titanium Dioxide-Induced Liver Injury

Cited by 32 publications

References 40 publications

Food components with antifibrotic activity and implications in prevention of liver disease

Food components with antifibrotic activity and implications in prevention of liver disease

Effect of nanopolysaccharide (BSEPS) from Bacillus subtilis sp. on thioacetamide-induced liver fibrosis in rats

Downregulation of flt-1 and HIF-1α Gene Expression by Some Antioxidants in Rats Under Sodium Nitrite–Induced Hypoxic Stress

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