Potential antimalarials from Nigerian plants: A review

Adebayo, Joseph O.; Krettli, Antoniana U.

doi:10.1016/j.jep.2010.11.024

Cited by 226 publications

(178 citation statements)

References 125 publications

(114 reference statements)

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“…These results affected our research on plants. Recently, species that have been used elsewhere against malaria, such as in Nigeria and other African countries, have been reviewed (Adebayo & Krettli 2011); however, the only species that we tested, Coccus nucirefa, had little, if any, activity (Adebayo et al 2012).…”

Section: Strategies Used To Discover New Antimalarial Drugs -A Searchmentioning

confidence: 99%

New approaches in antimalarial drug discovery and development: a review

Aguiar

Rocha

Souza

et al. 2012

Mem. Inst. Oswaldo Cruz

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Malaria remains a major world health problem following the emergence and spread of Plasmodium falciparum that is resistant to the majority of antimalarial drugs. This problem has since been aggravated by a decreased sensitivity of Plasmodium vivax to chloroquine. This review discusses strategies for evaluating the antimalarial activity of new compounds in vitro and in animal models ranging from conventional tests to the latest high-throughput screening technologies. Antimalarial discovery approaches include the following: the discovery of antimalarials from natural sources, chemical modifications of existing antimalarials, the development of hybrid compounds, testing of commercially available drugs that have been approved for human use for other diseases and molecular modelling using virtual screening technology and docking. Using these approaches, thousands of new drugs with known molecular specificity and active against P. falciparum have been selected. The inhibition of haemozoin formation in vitro, an indirect test that does not require P. falciparum cultures, has been described and this test is believed to improve antimalarial drug discovery. Clinical trials conducted with new funds from international agencies and the participation of several industries committed to the eradication of malaria should accelerate the discovery of drugs that are as effective as artemisinin derivatives, thus providing new hope for the control of malaria

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Section: Strategies Used To Discover New Antimalarial Drugs -A Searchmentioning

confidence: 99%

New approaches in antimalarial drug discovery and development: a review

Aguiar

Rocha

Souza

et al. 2012

Mem. Inst. Oswaldo Cruz

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“…Plants produce phytochemicals which have protective or preventive properties against human diseases. Antimalarial activities of many medicinal plants have been reported [33][34][35] . In this study anti-malarial activity of the extract and fractions of B. ocymoides were tested using in vivo anti-plasmodial effect against chloroquinesensitive Plasmodium berghei NK 65-infected mice.…”

Section: Discussionmentioning

confidence: 99%

Antimalarial and Antioxidant Potentials of Extract and Fractions of Aerial part of Borreria ocymoides DC (Rubiaceae).

Adesegun¹,

Orabueze²,

Coker³

2017

Phcog J

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Introduction: Borreria ocymoides (Burm F) DC is a weak, erect and decumbent herb that has several folkloric, ethno medicinal uses and is included in antimalarial preparations by some traditional healers. It is also used in treatment of ring worm, eczema and microbial infections. Objectives: To evaluate antimalarial activity of extract and fractions of Borreria ocymoides in Plasmodium berghei infected mice and to investigate their antioxidant activity using 1, 1-diphenyl-2-picryl-hydrazile (DPPH). Methods: The methanol extract of aerial part of B. ocymoides and the solvent fractions obtained from partition between organic solvents were assessed for antimalarial activity against chloroquine sensitive Plasmodium berghei NK65 infected mice using the suppressive and curative test procedures. Chloroquine (10 mg/ml) was used as positive control. The antioxidant activity was evaluated using DPPH radical scavenging ability and determination of total phenolic content. Results: The crude extract (250 and 500 mg kg-1) produced a dose dependent anti-plasmodial activity in the suppressive and curative tests. The chemo suppression activity was best in the ethyl acetate fraction (87.31%) and in the order ethyl acetate >dichloromethane > hexane > aqueous fraction. The DPPH radical scavenging activity of the extract increased with concentration. The antioxidant activity was less than ascorbic acid used as positive control. Oral administration up to 5 g/kg produced no noticeable deleterious effect 24 hours after dosing and up to 7 days afterwards. Conclusion:The results indicated that the extract has a potent anti-plasmodial activity against Plasmodium berghei and the activity seems to reside in the mid-polar fractions. Thus, the plant is a potential source of new antimalarial agents.

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“…Syncarpamide and decarine, two compounds isolated from Z. syncarpum have showed strong in vitro antiplasmodial activity against D6 (chloroquine sensitive clone) and W2 (chloroquine resistant clone) P. falciparum strains, having IC 50 values lower than 6.1 µM (Kaur et al, 2009;Ross et al, 2005;Ross et al, 2004). The crude alkaloid extract obtained from the bark of Z. zanthoxyloides and fagaronine, a benzophenanthridine alkaloid derived from the root extract of Z. zanthoxyloides; inhibited P. falciparum growth in vitro at low IC 50 (Adebayo & Krettli, 2011;Gansane et al, 2010). Also have been reported positive results of antimalarial activity for the ethanolic extract from stem bark of Z. guilletti (Zirihi et al, 2009) and for the chloroform crude extract from fruits of Z. limonella (Charoenying et al, 2008).…”

Section: Wwwintechopencommentioning

confidence: 99%