Potential Antioxidant Effects of Zinc and Chromium Supplementation in People with Type 2 Diabetes Mellitus

Anderson, Richard A.; Roussel, Anne‐Marie; Zouari, N.; Mahjoub, S.; Matheau, Jean-Marc; Kerkeni, Abdelhamid

doi:10.1080/07315724.2001.10719034

Cited by 277 publications

(200 citation statements)

References 27 publications

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“…It has been reported that GSH, various antioxidant vitamins and compounds, trace elements such as vitamins C and E, flavanoids, saponins, vanadium, and selenium prevent the increase of tissue NEG levels. 44) We found a reduction of the NEG increase in the tissues of the animals to which chard extract was administered, producing a significant decrease in the diabetic group. Lipid peroxidation has been implicated in the pathogenesis of many degenerative disorders, including chemically induced diabetes.…”

Section: Discussionmentioning

confidence: 76%

Effects of Chard (Beta vulgarisL. var cicla) on the Liver of the Diabetic Rats: A Morphological and Biochemical Study

Saçan

Karabulut-Bulan

Bolkent

et al. 2004

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 76%

Effects of Chard (Beta vulgarisL. var cicla) on the Liver of the Diabetic Rats: A Morphological and Biochemical Study

Saçan

Karabulut-Bulan

Bolkent

et al. 2004

Bioscience, Biotechnology, and Biochemistry

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“…No unpublished studies were found. Fourteen studies were excluded because they were either not randomized, double-blind and placebocontrolled, [31][32][33][34][35] did not test a monopreparation of chromium picolinate, [36][37][38][39][40] did not report on body weight [41][42][43] or were published in duplicate. 44 Ten trials met all inclusion criteria and provided data for body weight that were suitable for statistical pooling (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Chromium picolinate for reducing body weight: Meta-analysis of randomized trials

2003

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The aim of this meta-analysis was to assess the evidence of chromium picolinate for reducing body weight. Literature searches were conducted on Medline, Embase, The Cochrane Library, Amed and Ciscom. Nine experts and four manufacturers of commercial preparations containing chromium picolinate were asked to contribute published and unpublished studies. There were no restrictions regarding the language of publication. The screening of studies, selection, data extraction, validation and the assessment of methodological quality were performed independently by two reviewers. To be included, studies were required to state that they were randomized, double-blind and placebo-controlled, and report on body weight. Ten trials met all inclusion criteria and provided data, which were suitable for statistical pooling. For body weight a significant differential effect was found in favour of chromium picolinate (weighted mean difference: À1.1 kg; 95% confidence interval (CI): À1.8 to À0.4 kg, n ¼ 489). Sensitivity analysis suggests that this effect is largely dependent on the results of a single trial (weighted mean difference: À0.9 kg; 95% CI: À2.0 to 0.2 kg, n ¼ 335). Three of the reviewed trials reported on adverse events, indicating their absence in the treatment groups. In conclusion, our meta-analysis suggests a relatively small effect of chromium picolinate compared with placebo for reducing body weight. The clinical relevance of the effect is debatable and the lack of robustness means that the result has to be interpreted with caution.

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“…A significant decrease in Zn++ and Se++ levels in whole blood has been reported in diabetic pregnancy (24,25,26), compared to normoglycemic pregnancy. The potential beneficial effects of Zinc and Chromium have been reported in patients with type 2 diabetes mellitus (27)(28)(29).…”

Section: Introductionmentioning

confidence: 99%

Trace elements and cell-mediated immunity in gestational and pre-gestational diabetes mellitus at third trimester of pregnancy

Mahmoud¹

2012

AMA

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Objective. The aim of the study: To evaluate the correlations between Zn2+, Cu2+, Mg2+, Se2+ and Cr3+ and alteration in T cell subsets during diabetic and normal pregnancy. Methods. The study involved 63 women with gestational diabetes mellitus (GD) and 16 pregnant women with Type 2 diabetes and 48 healthy, non-pregnant women were included as controls. Ten ml of whole venous blood from each participant was analyzed for electrolytes by atomic absorption; total antioxidant activity, individual enzymatic antioxidants by spectrophotometry; and lymphocyte sub-populations by flow cytometry. Results. There were significant changes in lymphocyte sub-populations: Naïve T cells were decreased and memory T-cells and activated T cells (CD4+HLA-DR+, CD4+CD29+) were increased in diabetes in pregnancy. Zn2+ and Cr3+ deficiency were observed in Type 2 diabetics with an increase in Cu2+ in all pregnant cohorts. In healthy pregnant subjects, CD4+-HLA-DR+ was increased in direct proportion to serum Mg2+ (p<0.05) and Se2+ (p<0.01). In insulin-treated GD patients, CD4+CD29+ cells were increased proportionally to serum Zn2+ (p<0.05) while in diet controlled GD cohort CD45RO+/ CD45RA+ T cells correlated directly with serum Mg (p<0.05) and Zn2+ (p<0.01) while it correlated inversely with serum Cu2+ (p<0.01). Conclusions. The results of the present study show a correlation between trace element deficiency and increased lipid peroxidation in diabetes in pregnancy and lymphocyte activation. Dietary manipulation may, therefore, point to improvement in existing approaches to management of diabetes mellitus in pregnancy.

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Potential Antioxidant Effects of Zinc and Chromium Supplementation in People with Type 2 Diabetes Mellitus

Abstract: These data suggest the potential beneficial antioxidant effects of the individual and combined supplementation of Zn and Cr in people with type 2 DM. These results are particularly important in light of the deleterious consequences of oxidative stress in people with diabetes.

Cited by 277 publications

References 27 publications

Effects of Chard (Beta vulgarisL. var cicla) on the Liver of the Diabetic Rats: A Morphological and Biochemical Study

Effects of Chard (Beta vulgarisL. var cicla) on the Liver of the Diabetic Rats: A Morphological and Biochemical Study

Chromium picolinate for reducing body weight: Meta-analysis of randomized trials

Trace elements and cell-mediated immunity in gestational and pre-gestational diabetes mellitus at third trimester of pregnancy

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